Mark Cookson
@markrcookson.bsky.social
Cell Biologist accidentally thinking about human genetics. He/him. Husband, Dad, wannabe musician and cook, immigrant. Views very definitely my own.
Pinned
Mark Cookson
@markrcookson.bsky.social
· Nov 13
Human <span>iPS</span> Cells
In partnership with the iPSC Neurodegenerative Disease Initiative, a project from the Center for Alzheimer’s and Related Dementias (NIH), and with support from the Chan Zuckerberg Initiative, and Alig...
www.jax.org
May as well start out with our big resource. We spent a long time getting this up and running - and it's now a real thing and still growing! Repost!!!
www.jax.org/jax-mice-and...
www.jax.org/jax-mice-and...
Reposted by Mark Cookson
In @jcb.org, @lysoluis.bsky.social, @markrcookson.bsky.social et al. show how two distinct pRAB effectors and RHD members, JIP4 and RILPL1, provide antagonistic motor force to regulate #lysosome tubulation. rupress.org/jcb/article/...
September 24, 2025 at 5:10 PM
In @jcb.org, @lysoluis.bsky.social, @markrcookson.bsky.social et al. show how two distinct pRAB effectors and RHD members, JIP4 and RILPL1, provide antagonistic motor force to regulate #lysosome tubulation. rupress.org/jcb/article/...
I heard Norway is recruiting “top” researchers to leave some countries and join them. Yet I have not had a call. Hallo?
April 24, 2025 at 2:02 AM
I heard Norway is recruiting “top” researchers to leave some countries and join them. Yet I have not had a call. Hallo?
Reposted by Mark Cookson
This is a sign of how upside down the constitutional order is right now. The President is supposed to ask Congress for money, not the other way around! #mepolitics
Sen. Susan Collins on Thursday vowed to fight cutbacks to National Institutes of Health research grants, saying she will personally lobby the Trump administration and is helping to form a broad coalition in an attempt to reverse the funding caps.
Sen. Susan Collins vows to fight medical research cuts
The Maine Republican said she is helping to form a coalition to undo Trump administration cutbacks, and will also lobby HHS Secretary Robert F. Kennedy Jr.
www.pressherald.com
February 27, 2025 at 10:33 PM
This is a sign of how upside down the constitutional order is right now. The President is supposed to ask Congress for money, not the other way around! #mepolitics
Reposted by Mark Cookson
I don't really have words for how devastating it would be to lose the entire intramural program. This has to be stopped.
More hits to #NIH:
"The Trump administration has imposed a new restriction on employment that could push out thousands of NIH’s senior scientists: The agency cannot retain scientists in 1-year to 4-year positions that have long been routinely renewed." 🧪
@jocelynkaiser.bsky.social at @science.org
"The Trump administration has imposed a new restriction on employment that could push out thousands of NIH’s senior scientists: The agency cannot retain scientists in 1-year to 4-year positions that have long been routinely renewed." 🧪
@jocelynkaiser.bsky.social at @science.org
NIH ban on renewing senior scientists adds to assaults on its in-house research
Policy follows firings of tenure-track scientists and suspension of training programs
www.science.org
February 27, 2025 at 6:08 AM
I don't really have words for how devastating it would be to lose the entire intramural program. This has to be stopped.
Reposted by Mark Cookson
Just astonishing.
Scientists, please just READ what Jay Bhattacharya has said in public. It is bad.
www.techdirt.com/202...
www.techdirt.com/202...
For Bhattacharya, Free Speech Means Freedom To Defund Dissenters
Over at MSNBC, I have a new piece debunking the false claims from many that Donald Trump’s pick to run the National Institutes of Health, Jay Bhattacharya, is somehow taking over the government age…
www.techdirt.com
February 27, 2025 at 1:58 PM
Just astonishing.
Reposted by Mark Cookson
"Memoli had no choice, he insisted: He was following the direction of three HHS officials—Dorothy Fink, then the acting secretary; Heather Flick Melanson, chief of staff; and Hannah Anderson, deputy chief of staff of policy—who told him, in no uncertain terms, that the pause was to continue..."
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Inside the Collapse at the NIH
Administration officials pressured the NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.
www.theatlantic.com
February 27, 2025 at 7:11 PM
"Memoli had no choice, he insisted: He was following the direction of three HHS officials—Dorothy Fink, then the acting secretary; Heather Flick Melanson, chief of staff; and Hannah Anderson, deputy chief of staff of policy—who told him, in no uncertain terms, that the pause was to continue..."
/1
/1
Reposted by Mark Cookson
The future of science in the U.S. is looking so promising.
February 28, 2025 at 12:13 AM
The future of science in the U.S. is looking so promising.
Reposted by Mark Cookson
Ensure the voices of people living with dementia and their caregivers are heard. Urge your members of Congress to reaffirm their commitment to the Alzheimer’s community today. We’ve made great progress and we cannot afford to stop now. bit.ly/alzaction
February 26, 2025 at 4:50 PM
Ensure the voices of people living with dementia and their caregivers are heard. Urge your members of Congress to reaffirm their commitment to the Alzheimer’s community today. We’ve made great progress and we cannot afford to stop now. bit.ly/alzaction
Reposted by Mark Cookson
I was part of the Marzi lab for my masters, PhD, and now postdoc. @sj-marzi.bsky.social is an enthusiastic scientist and supportive mentor. The science is cool and the people are even cooler. Can’t recommend enough!!! 🤓
Apply apply apply 👇🏻
Apply apply apply 👇🏻
February 22, 2025 at 10:56 AM
I was part of the Marzi lab for my masters, PhD, and now postdoc. @sj-marzi.bsky.social is an enthusiastic scientist and supportive mentor. The science is cool and the people are even cooler. Can’t recommend enough!!! 🤓
Apply apply apply 👇🏻
Apply apply apply 👇🏻
What fresh hell is this? Have a tea bag of reasonable repute in my hotel room but it’s decaffeinated? What use will this be tomorrow am???
December 2, 2024 at 2:32 AM
What fresh hell is this? Have a tea bag of reasonable repute in my hotel room but it’s decaffeinated? What use will this be tomorrow am???
Reposted by Mark Cookson
Reposted by Mark Cookson
A two-month-old has died from pertussis in Queensland, Australia. Like many countries including the US, Australia is in the midst of a pertussis epidemic. In Queensland, uptake of maternal pertussis vaccination & infant vaccinations have declined. Lower rates of both put the youngest at risk.
Infant dies amid worst Queensland whooping cough epidemic on record
Queensland Health confirms child’s death from highly contagious infection as vaccination rates plummet and cases spike across Australia
www.theguardian.com
November 27, 2024 at 3:18 PM
A two-month-old has died from pertussis in Queensland, Australia. Like many countries including the US, Australia is in the midst of a pertussis epidemic. In Queensland, uptake of maternal pertussis vaccination & infant vaccinations have declined. Lower rates of both put the youngest at risk.
useful rubric for those of us who love logic from @michelerosenthal.com
Just in case this comes in handy in the next, say, few years or so
Just in case this comes in handy in the next, say, few years or so
November 27, 2024 at 1:58 PM
useful rubric for those of us who love logic from @michelerosenthal.com
Just in case this comes in handy in the next, say, few years or so
Just in case this comes in handy in the next, say, few years or so
Hey @mahoneykc.bsky.social more evolutionary information for you
November 26, 2024 at 2:29 PM
Hey @mahoneykc.bsky.social more evolutionary information for you
Reposted by Mark Cookson
In remembrance of those lost to COVID-19, I created a Spotify playlist featuring songs by musicians who passed away from the disease: open.spotify.com/playlist/6jE.... So much beautiful humanity gone.
Musicians lost to COVID-19
Playlist · jbonifacino1 · 23 items
open.spotify.com
November 26, 2024 at 1:45 AM
In remembrance of those lost to COVID-19, I created a Spotify playlist featuring songs by musicians who passed away from the disease: open.spotify.com/playlist/6jE.... So much beautiful humanity gone.
Patrick Stewart on behalf of many other old white men
November 19, 2024 at 1:58 PM
Patrick Stewart on behalf of many other old white men
Reposted by Mark Cookson
Interesting story!
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
www.science.org
November 19, 2024 at 1:35 PM
Interesting story!
Reposted by Mark Cookson
Interested in lysosomes? Fully funded iCASE PhD studentship available between me at RVC, Emily Eden at UCL, and Andreas Dannhorn at AstraZeneca. Details below…
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Integrated analysis of chemical induced lysosomal cytotoxicity at Royal Veterinary College on FindAPhD.com
PhD Project - Integrated analysis of chemical induced lysosomal cytotoxicity at Royal Veterinary College, listed on FindAPhD.com
www.findaphd.com
November 19, 2024 at 10:24 AM
Interested in lysosomes? Fully funded iCASE PhD studentship available between me at RVC, Emily Eden at UCL, and Andreas Dannhorn at AstraZeneca. Details below…
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Mark Cookson
Haploinsufficiency of lysosomal enzyme genes in Alzheimers disease https://www.biorxiv.org/content/10.1101/2024.11.16.623962v1
Haploinsufficiency of lysosomal enzyme genes in Alzheimers disease https://www.biorxiv.org/content/10.1101/2024.11.16.623962v1
There is growing evidence suggesting that the lysosome or lysosome dysfunction is associated with Al
www.biorxiv.org
November 18, 2024 at 11:16 PM
Haploinsufficiency of lysosomal enzyme genes in Alzheimers disease https://www.biorxiv.org/content/10.1101/2024.11.16.623962v1
Reposted by Mark Cookson
I've finally found out why I am stretched to capacity all the time. I've been saying NO to people for years but Americans need that translating
November 18, 2024 at 2:12 PM
I've finally found out why I am stretched to capacity all the time. I've been saying NO to people for years but Americans need that translating
Hey @meganduffyphd.bsky.social, need some postage stamps? www.theguardian.com/us-news/2024...
US Postal Service honors Betty White with new postage stamp
Golden Girls actor appears on illustrated stamp that exudes her ‘spritely sense of fun’ for 2025 release
www.theguardian.com
November 18, 2024 at 5:53 PM
Hey @meganduffyphd.bsky.social, need some postage stamps? www.theguardian.com/us-news/2024...
I've finally found out why I am stretched to capacity all the time. I've been saying NO to people for years but Americans need that translating
November 18, 2024 at 2:12 PM
I've finally found out why I am stretched to capacity all the time. I've been saying NO to people for years but Americans need that translating
Reposted by Mark Cookson
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
November 15, 2024 at 5:55 PM
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
Reposted by Mark Cookson
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
November 16, 2024 at 2:17 PM
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Mark Cookson
Clarivate will strip eLife of its Impact Factor
They never wanted one but will be interesting to see how this affects submissions given academia's obsession with it.
retractionwatch.com/2024/11/13/e...
But 1/2
They never wanted one but will be interesting to see how this affects submissions given academia's obsession with it.
retractionwatch.com/2024/11/13/e...
But 1/2
eLife won’t get an impact factor, says Clarivate
Clarivate, the data company for scholarly publications, has decided to continue indexing some content from eLife in Web of Science, after reevaluating the open-access biology journal’s unusual prac…
retractionwatch.com
November 14, 2024 at 2:47 PM
Clarivate will strip eLife of its Impact Factor
They never wanted one but will be interesting to see how this affects submissions given academia's obsession with it.
retractionwatch.com/2024/11/13/e...
But 1/2
They never wanted one but will be interesting to see how this affects submissions given academia's obsession with it.
retractionwatch.com/2024/11/13/e...
But 1/2