Marianø Dellarøle
@marianodella.bsky.social
Reposted by Marianø Dellarøle
❗New Preprint w/ C Bueno (@cabb99.bsky.social), IE Sánchez (@nachoquique.bsky.social), PG Wolynes & DU Ferreiro (@diegulise.bsky.social)
We define the Protein Dark Energy and use it to localize and quantify the functional evolutionary constraints on natural proteins
arxiv.org/abs/2508.08109
We define the Protein Dark Energy and use it to localize and quantify the functional evolutionary constraints on natural proteins
arxiv.org/abs/2508.08109
Probing the Dark Energy in the Functional Protein Universe
We show how to localize and quantify the functional evolutionary constraints on natural proteins. The method compares the perturbations caused by local sequence variants to the energetics of the prote...
arxiv.org
August 12, 2025 at 2:49 PM
❗New Preprint w/ C Bueno (@cabb99.bsky.social), IE Sánchez (@nachoquique.bsky.social), PG Wolynes & DU Ferreiro (@diegulise.bsky.social)
We define the Protein Dark Energy and use it to localize and quantify the functional evolutionary constraints on natural proteins
arxiv.org/abs/2508.08109
We define the Protein Dark Energy and use it to localize and quantify the functional evolutionary constraints on natural proteins
arxiv.org/abs/2508.08109
Reposted by Marianø Dellarøle
1/x New story - the structure of the Vault cap, at 2.3Å! Matching a beautiful preprint from @sjorsscheres.bsky.social, we show that the cap of the vault particle has C13 symmetry, in contrast to the 39-fold symmetry of the body. Study lead by talented postdoc @huanli00.bsky.social from my group! ⬇️
June 12, 2025 at 1:44 PM
1/x New story - the structure of the Vault cap, at 2.3Å! Matching a beautiful preprint from @sjorsscheres.bsky.social, we show that the cap of the vault particle has C13 symmetry, in contrast to the 39-fold symmetry of the body. Study lead by talented postdoc @huanli00.bsky.social from my group! ⬇️
Reposted by Marianø Dellarøle
I'm super happy that our story is now published!
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
March 21, 2025 at 2:09 PM
I'm super happy that our story is now published!
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
Reposted by Marianø Dellarøle
Out just now @naturecomms.bsky.social: using cryo-EM and cryo-electron tomography, we provide evidence that structurally heterogeneous ribosomes can cooperate in protein synthesis in bacterial cells:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells - Nature Communications
Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...
www.nature.com
March 21, 2025 at 8:50 AM
Out just now @naturecomms.bsky.social: using cryo-EM and cryo-electron tomography, we provide evidence that structurally heterogeneous ribosomes can cooperate in protein synthesis in bacterial cells:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Marianø Dellarøle
🚀 #AlphaFold Database update
AlphaFold DB now integrates The Encyclopedia of Domains (TED) – a resource designed to systematically identify & classify structural domains within AlphaFold-predicted protein structures.
www.ebi.ac.uk/about/news/u...
@pdbeurope.bsky.social
AlphaFold DB now integrates The Encyclopedia of Domains (TED) – a resource designed to systematically identify & classify structural domains within AlphaFold-predicted protein structures.
www.ebi.ac.uk/about/news/u...
@pdbeurope.bsky.social
March 3, 2025 at 4:33 PM
🚀 #AlphaFold Database update
AlphaFold DB now integrates The Encyclopedia of Domains (TED) – a resource designed to systematically identify & classify structural domains within AlphaFold-predicted protein structures.
www.ebi.ac.uk/about/news/u...
@pdbeurope.bsky.social
AlphaFold DB now integrates The Encyclopedia of Domains (TED) – a resource designed to systematically identify & classify structural domains within AlphaFold-predicted protein structures.
www.ebi.ac.uk/about/news/u...
@pdbeurope.bsky.social
Reposted by Marianø Dellarøle
Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social
February 28, 2025 at 2:04 PM
Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social
Reposted by Marianø Dellarøle
Estamos muy contentos de compartir nuestro último trabajo "Tertiary and quaternary structure remodeling by occupancy of the substrate binding pocket in a large glutamate dehydrogenase". doi.org/10.1101/2024...
December 27, 2024 at 11:46 AM
Estamos muy contentos de compartir nuestro último trabajo "Tertiary and quaternary structure remodeling by occupancy of the substrate binding pocket in a large glutamate dehydrogenase". doi.org/10.1101/2024...
Reposted by Marianø Dellarøle
Let’s hear from our nodes at the CEBEM Annual Meeting #2024!
We are thrilled to learn about the experiences, challenges and achievements from our incredible network nodes 👇
#ImagingTheFuture
We are thrilled to learn about the experiences, challenges and achievements from our incredible network nodes 👇
#ImagingTheFuture
December 16, 2024 at 8:57 PM
Let’s hear from our nodes at the CEBEM Annual Meeting #2024!
We are thrilled to learn about the experiences, challenges and achievements from our incredible network nodes 👇
#ImagingTheFuture
We are thrilled to learn about the experiences, challenges and achievements from our incredible network nodes 👇
#ImagingTheFuture
Reposted by Marianø Dellarøle
🇦🇷 @marianodella.bsky.social shared the facilities and different research lines at #CIBION as well as how they are actively working to develop a Cryo-EM platform in Argentina.
#CEBEM #ImagingTheFuture
#CEBEM #ImagingTheFuture
December 16, 2024 at 9:27 PM
🇦🇷 @marianodella.bsky.social shared the facilities and different research lines at #CIBION as well as how they are actively working to develop a Cryo-EM platform in Argentina.
#CEBEM #ImagingTheFuture
#CEBEM #ImagingTheFuture
Reposted by Marianø Dellarøle
"Infectious parvovirus B19 circulates in the blood coated with active host protease inhibitors"
#virology #cryoEM
www.nature.com/articles/s41...
#virology #cryoEM
www.nature.com/articles/s41...
Infectious parvovirus B19 circulates in the blood coated with active host protease inhibitors - Nature Communications
This study presents the first high-resolution structure of infectious parvovirus B19, purified from a patient. Two acute phase reactants, serpinA3, and ITIH4, bind to the capsid, suggesting B19V utili...
www.nature.com
November 18, 2024 at 4:56 PM
"Infectious parvovirus B19 circulates in the blood coated with active host protease inhibitors"
#virology #cryoEM
www.nature.com/articles/s41...
#virology #cryoEM
www.nature.com/articles/s41...