We end with a set of recommendations aimed to address these considerations. Note that this is a pre-print and may thus still be subject to change!
Many thanks to @evangiangrande.bsky.social @appelbap.bsky.social @lucasjmatthews.bsky.social & Emily Bassett

In this pre-print, we address these ethical and legal considerations (particularly with respect to informed consent), the importance of transparent science communiciation, and how robust regulatory frameworks guiding IRBs on novel advanced methods such as Mendelian imputation are currently missing

Mendelian imputation is a promising method for imputing missing parental genotypes and estimating direct genetic effects. While the method has clear scientific benefits, so far there has been little reflection on its legal and ethical implications.