Marco Bocchio
marcobocchio.bsky.social
Marco Bocchio
@marcobocchio.bsky.social
Neuroscientist. Assistant Prof at Durham Uni. Neuromodulation of the brain circuits. Interneurons, serotonin, psychedelics. nmoclab.com
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June 19, 2025 at 10:16 AM
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April 10, 2025 at 3:35 PM
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January 17, 2025 at 12:46 PM
Finally, we examined the effect of single interneuron optical stimulation on SCEs and cell assemblies. This showed that activation of single interneurons favours both SCEs and the reinstatement of endogenous cell assemblies.
November 18, 2024 at 9:40 AM
We then interrogated a rate-based network model with hippocampal-like connectivity motifs. We found that cell assemblies and dense but unspecific connectivity between interneurons are necessary ingredients to explain the effects of interneuron stimulation
November 18, 2024 at 9:40 AM
Activating a single interneuron, surprisingly, triggered mostly excitatory responses in pyramidal cells. It mostly triggered inhibition in inhibitory neurons, suggesting disinhibitory effects at play
November 18, 2024 at 9:40 AM
To probe causality, we combined imaging and holographic stimulation of single interneurons with optogenetics
November 18, 2024 at 9:40 AM
Interneuron formed a strong network with high functional connectivity. And association of pyramidal cells with interneurons positively correlated with pyramidal cell-pyramidal cell correlations as well synchronous network bursts (SCEs).
November 18, 2024 at 9:40 AM
In the present study, we first imaged CA1 interneurons and pyramidal cell ensembles in mice running spontaneously on a treadmill.
November 18, 2024 at 9:40 AM