Marco A Calzado
@marcoacalzado.bsky.social
Professor @uco.es, Scientist @IMIBIC, Immunologist, Molecular Biologist, Father, and Technology Enthusiast.
📉 Se me han bajado los niveles de dopamina, y la única cura es: vacaciones.😎 La ciencia puede seguir sin mí… al menos unos días (o eso quiero creer). 😂😂 👋 Nos vemos cuando recupere mi homeostasis.
the sun shines through the trees in the foreground
ALT: the sun shines through the trees in the foreground
media.tenor.com
July 30, 2025 at 5:36 AM
📉 Se me han bajado los niveles de dopamina, y la única cura es: vacaciones.😎 La ciencia puede seguir sin mí… al menos unos días (o eso quiero creer). 😂😂 👋 Nos vemos cuando recupere mi homeostasis.
Salir a correr en Córdoba después de las 9:00 a.m. no es deporte, es una prueba de supervivencia. Se llama: 100 metros deshidratado estilo lagarto en asfalto. 🦎🔥💀🏃🏻🏃🏻♂️
a man wearing headphones is sweating while sitting in an airplane .
ALT: a man wearing headphones is sweating while sitting in an airplane .
media.tenor.com
June 21, 2025 at 11:16 AM
Salir a correr en Córdoba después de las 9:00 a.m. no es deporte, es una prueba de supervivencia. Se llama: 100 metros deshidratado estilo lagarto en asfalto. 🦎🔥💀🏃🏻🏃🏻♂️
Excited to share that I’m now part of the Editorial Board of Oncogene. I’ve long been a fan of the journal and look forward to contributing to its continued excellence #Oncogene #NaturePublishingGroup
www.nature.com/onc/
www.nature.com/onc/
Oncogene
Oncogene aims to make substantial advances in our knowledge of processes that contribute to cancer by publishing outstanding research. Oncogene propagates ...
www.nature.com
June 16, 2025 at 2:32 PM
Excited to share that I’m now part of the Editorial Board of Oncogene. I’ve long been a fan of the journal and look forward to contributing to its continued excellence #Oncogene #NaturePublishingGroup
www.nature.com/onc/
www.nature.com/onc/
Reposted by Marco A Calzado
Springer-Nature launched a series of "Discover" journals that closely mimic MDPI titles -- sharing *identical* journal names, and likely similar business model.
What is going on, and why researcher will - as always - fall for it?
A 🧵
the-strain-on-scientific-publishing.github.io/website/post...
What is going on, and why researcher will - as always - fall for it?
A 🧵
the-strain-on-scientific-publishing.github.io/website/post...
Springer Nature Discovers MDPI – The Strain on Scientific Publishing
Home page for the paper ‘The Strain on Scientific Publishing’ by Mark A Hanson, Dan Brockington, Paolo Crosetto and Pablo Gomez Barreiro
the-strain-on-scientific-publishing.github.io
June 15, 2025 at 2:21 PM
Springer-Nature launched a series of "Discover" journals that closely mimic MDPI titles -- sharing *identical* journal names, and likely similar business model.
What is going on, and why researcher will - as always - fall for it?
A 🧵
the-strain-on-scientific-publishing.github.io/website/post...
What is going on, and why researcher will - as always - fall for it?
A 🧵
the-strain-on-scientific-publishing.github.io/website/post...
Reposted by Marco A Calzado
To accelerate #mRNA vaccine and therapy research, we're excited to share our end-to-end protocol for mRNA design, synthesis and encapsulation in @natprot.nature.com.
Protocol development led by @laura-leighton.bsky.social, Natasha Chaudhary and Tim Mercer.@basemrna.bsky.social
rdcu.be/eqiF1
Protocol development led by @laura-leighton.bsky.social, Natasha Chaudhary and Tim Mercer.@basemrna.bsky.social
rdcu.be/eqiF1
The design, manufacture and LNP formulation of mRNA for research use
Nature Protocols - This protocol describes simple, small-scale laboratory production of mRNA for research and preclinical use. This includes sequence design, DNA template production, mRNA synthesis...
rdcu.be
June 10, 2025 at 11:39 PM
To accelerate #mRNA vaccine and therapy research, we're excited to share our end-to-end protocol for mRNA design, synthesis and encapsulation in @natprot.nature.com.
Protocol development led by @laura-leighton.bsky.social, Natasha Chaudhary and Tim Mercer.@basemrna.bsky.social
rdcu.be/eqiF1
Protocol development led by @laura-leighton.bsky.social, Natasha Chaudhary and Tim Mercer.@basemrna.bsky.social
rdcu.be/eqiF1
Off goes the revised manuscript, fatter and wiser after surviving another round of experiments. May the reviewers be kind, merciful… and slightly distracted. 🤞📤 #Resubmitted #ReviewerBeNice
a woman in a black jacket is giving the middle finger while standing in the water .
ALT: a woman in a black jacket is giving the middle finger while standing in the water .
media.tenor.com
June 11, 2025 at 3:16 PM
Off goes the revised manuscript, fatter and wiser after surviving another round of experiments. May the reviewers be kind, merciful… and slightly distracted. 🤞📤 #Resubmitted #ReviewerBeNice
Amazing discovery 🙀 www.nature.com/articles/s41...
Maternal iron deficiency causes male-to-female sex reversal in mouse embryos - Nature
Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.
www.nature.com
June 4, 2025 at 11:30 PM
Amazing discovery 🙀 www.nature.com/articles/s41...
Reposted by Marco A Calzado
Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d
Silencing mitochondrial gene expression in living cells
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms u...
scim.ag
May 23, 2025 at 7:23 PM
Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d
Reposted by Marco A Calzado
Reposted by Marco A Calzado
Proteasome: An antibiotic arsenal in anti-bacterial innate immunity
Proteasome: An antibiotic arsenal in anti-bacterial innate immunity
The function of the proteasome besides degrading protein remains enigmatic. Goldberg et al. demonstrate that proteasomes can process proteins into antimicrobial peptides (AMPs) to ward off bacterial infection, revealing a new function of proteasomes in innate immunity.
dlvr.it
May 19, 2025 at 7:14 PM
Proteasome: An antibiotic arsenal in anti-bacterial innate immunity
Reposted by Marco A Calzado
Researchers report that their new #AI has, in a matter of months, conjured up dozens of GPCR-targeting antibody candidates, which promise to work as well as drugs that have spent years in the traditional pipeline. scim.ag/3S4gjwb
AI conjures up potential new antibody drugs in a matter of months
Company finds candidates that bind to tricky proteins that deliver chemical messages in and out of cells
scim.ag
May 14, 2025 at 4:06 PM
Researchers report that their new #AI has, in a matter of months, conjured up dozens of GPCR-targeting antibody candidates, which promise to work as well as drugs that have spent years in the traditional pipeline. scim.ag/3S4gjwb
Reposted by Marco A Calzado
A new #ScienceAdvances study identifies a neuroimmune pathway for treating sepsis, finding that dopamine inhibits expression of a critical regulator of immunometabolism.
This suggests that pramipexole, a dopamine agonist, could effectively treat lethal infections. scim.ag/4kfAfrZ
This suggests that pramipexole, a dopamine agonist, could effectively treat lethal infections. scim.ag/4kfAfrZ
A neuroimmune pathway drives bacterial infection
Dysregulation of the dopamine-ACOD1 axis correlates with sepsis severity.
scim.ag
May 13, 2025 at 6:55 PM
A new #ScienceAdvances study identifies a neuroimmune pathway for treating sepsis, finding that dopamine inhibits expression of a critical regulator of immunometabolism.
This suggests that pramipexole, a dopamine agonist, could effectively treat lethal infections. scim.ag/4kfAfrZ
This suggests that pramipexole, a dopamine agonist, could effectively treat lethal infections. scim.ag/4kfAfrZ
Reposted by Marco A Calzado
Nivolumab combined with induction chemotherapy and radiotherapy in nasopharyngeal carcinoma: A multicenter phase 2 PLATINUM trial
Nivolumab combined with induction chemotherapy and radiotherapy in nasopharyngeal carcinoma: A multicenter phase 2 PLATINUM trial
Xu et al. conduct a single-arm, phase 2 study evaluating the efficacy and safety of nivolumab plus induction chemotherapy and radiotherapy in patients with nasopharyngeal carcinoma. This combination therapy sparing concurrent cisplatin improves failure-free survival compared with a historical benchmark, and has low toxicity and favorable patient-reported tolerability and quality-of-life.
dlvr.it
May 12, 2025 at 6:52 PM
Nivolumab combined with induction chemotherapy and radiotherapy in nasopharyngeal carcinoma: A multicenter phase 2 PLATINUM trial
Reposted by Marco A Calzado
The @ukdri.ac.uk is recruiting a Research Associate to investigate how E3 ubiquitin ligases drive degradation of protein aggregates in neurodegenerative disease. Closing date: 25th May
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Research Associate: Neurodegeneration and Protein Degradation
The UK DRI at Cambridge is recruiting a Research Associate to investigate how E3 ubiquitin ligases drive degradation of protein aggregates in neurodegeneration
www.dementiaresearcher.nihr.ac.uk
May 11, 2025 at 8:11 PM
The @ukdri.ac.uk is recruiting a Research Associate to investigate how E3 ubiquitin ligases drive degradation of protein aggregates in neurodegenerative disease. Closing date: 25th May
www.dementiaresearcher.nihr.ac.uk/job/research...
www.dementiaresearcher.nihr.ac.uk/job/research...
Reposted by Marco A Calzado
Targeting an overlooked protein complex could offer a fresh avenue to cancer therapy
https://go.nature.com/3Z8R7IJ
https://go.nature.com/3Z8R7IJ
Blocking a key node in cancer signalling unlocks therapeutic potential
Mutations in RAS enzymes commonly drive cancer. Targeting an overlooked protein complex that works with RAS offers a fresh avenue to cancer therapy.
go.nature.com
May 8, 2025 at 12:17 PM
Targeting an overlooked protein complex could offer a fresh avenue to cancer therapy
https://go.nature.com/3Z8R7IJ
https://go.nature.com/3Z8R7IJ
Reposted by Marco A Calzado
Nature research paper: Cell cycle duration determines oncogenic transformation capacity.
https://go.nature.com/3GBSklB
https://go.nature.com/3GBSklB
Cell cycle duration determines oncogenic transformation capacity - Nature
Total cell cycle duration is a key hallmark of cancer initiation, and determines whether defects in apoptosis, senescence, immune surveillance, angiogenesis, DNA repair, polarity and proliferation lead to cancer development.
go.nature.com
May 5, 2025 at 7:00 AM
Nature research paper: Cell cycle duration determines oncogenic transformation capacity.
https://go.nature.com/3GBSklB
https://go.nature.com/3GBSklB
Reposted by Marco A Calzado
Lepodisiran, an extended-duration, small interfering RNA, reduced lipoprotein(a) concentrations in participants with elevated levels. Full ALPACA trial results and Research Summary: nej.md/4kWjJyn
#MedSky #CardioSky
#MedSky #CardioSky
May 4, 2025 at 7:02 PM
Lepodisiran, an extended-duration, small interfering RNA, reduced lipoprotein(a) concentrations in participants with elevated levels. Full ALPACA trial results and Research Summary: nej.md/4kWjJyn
#MedSky #CardioSky
#MedSky #CardioSky
Nos conocimos hace 16 años como Ramón y Cajal y hemos compartido mucho desde entonces. Hoy, Catedráticos de Química Analítica, Ing. Hidráulica e Inmunología. Excelentes profesionales y mejores personas. La #uco tiene suerte de tenerlos a ambos como Profesores e Investigadores.
April 4, 2025 at 5:33 PM
Nos conocimos hace 16 años como Ramón y Cajal y hemos compartido mucho desde entonces. Hoy, Catedráticos de Química Analítica, Ing. Hidráulica e Inmunología. Excelentes profesionales y mejores personas. La #uco tiene suerte de tenerlos a ambos como Profesores e Investigadores.
Article submitted!
han solo from star wars is pointing at the camera with his finger .
ALT: han solo from star wars is pointing at the camera with his finger .
media.tenor.com
March 20, 2025 at 4:09 PM
Article submitted!
Why don’t you wear a suit? 🤮😔
March 1, 2025 at 7:29 PM
Why don’t you wear a suit? 🤮😔
Hoy, #DíaMundialContraElCáncer, recordamos que la investigación es clave. Hemos avanzado mucho en terapias dirigidas e inmunoterapia, pero aún queda mucho por hacer. Seguimos trabajando para entender mejor el cáncer y desarrollar mejores tratamientos. @univcordoba.bsky.social @imibic.bsky.social
February 4, 2025 at 8:49 PM
Hoy, #DíaMundialContraElCáncer, recordamos que la investigación es clave. Hemos avanzado mucho en terapias dirigidas e inmunoterapia, pero aún queda mucho por hacer. Seguimos trabajando para entender mejor el cáncer y desarrollar mejores tratamientos. @univcordoba.bsky.social @imibic.bsky.social
Today, we had the privilege of having @prieto-garcia.bsky.social at @IMIBIC talking about splicing, USP38, and proteostasis. A magnificent talk and excellent work! 🧬🧪🧫
January 23, 2025 at 5:24 PM
Today, we had the privilege of having @prieto-garcia.bsky.social at @IMIBIC talking about splicing, USP38, and proteostasis. A magnificent talk and excellent work! 🧬🧪🧫
Reposted by Marco A Calzado
It was great to share Science with people at the
IMIBIC! Great place 🙂. Really thanks to Manuel D. Gahete for the invitation and thanks to @marcoacalzado.bsky.social , Raul , @betsaidaop.bsky.social and others for nice time and plenty Scientific discussions.
IMIBIC! Great place 🙂. Really thanks to Manuel D. Gahete for the invitation and thanks to @marcoacalzado.bsky.social , Raul , @betsaidaop.bsky.social and others for nice time and plenty Scientific discussions.
Enjoying the Seminar by @prieto-garcia.bsky.social at the IMIBIC on Proteotoxic Cryptic Splicing in Diseases: the pathologically relevant interplay between #splicing, #proteostasis #ER-Phagy
January 23, 2025 at 5:09 PM
It was great to share Science with people at the
IMIBIC! Great place 🙂. Really thanks to Manuel D. Gahete for the invitation and thanks to @marcoacalzado.bsky.social , Raul , @betsaidaop.bsky.social and others for nice time and plenty Scientific discussions.
IMIBIC! Great place 🙂. Really thanks to Manuel D. Gahete for the invitation and thanks to @marcoacalzado.bsky.social , Raul , @betsaidaop.bsky.social and others for nice time and plenty Scientific discussions.