Kudos to @aheljo.bsky.social and the entire team for this important contribution to our mechanistic understanding of chromatin repression by the ChAHP complex. 🧬👏

In conclusion, we propose that ChAHP represents a functional module that enables sequence-specific targeting of chromatin remodeling activity to counteract the binding of other chromatin regulators.

ADNP binding to chromatin is independent of CHD4, and CHD4’s ATP-dependent remodeling activity is not required for its recruitment to these sites. Instead, CHD4 functions to restrict the access of other TFs, such as CTCF, to ChAHP target sites.

The prevailing view is that chromatin remodelers promote transcription factor (TF) binding by making chromatin more accessible. However, this paradigm is reversed in the case of the transcription factor ADNP and the chromatin remodeler CHD4 within the ChAHP complex.