Conchi Manzano
@manzanoc.bsky.social
Plant Developmental Biologist | Researcher at HHMI and UC Davis | Brady lab | Former Marie S. Curie fellow | Love Science, Arts and Philosophy
Reposted by Conchi Manzano
CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis | Science www.science.org/doi/10.1126/...
Very nice work from Holger Puchta & colleagues
Very nice work from Holger Puchta & colleagues
CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis
The genome of Arabidopsis thaliana consists of 10 chromosomes. By inducing CRISPR-Cas–mediated breaks at subcentromeric and subtelomeric sequences, we fused entire chromosome arms, obtaining two eight...
www.science.org
November 20, 2025 at 8:47 PM
CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis | Science www.science.org/doi/10.1126/...
Very nice work from Holger Puchta & colleagues
Very nice work from Holger Puchta & colleagues
Reposted by Conchi Manzano
Happy to see this paper from my time with @spicybotrytis.bsky.social out in @theplantcell.bsky.social!
Amanda, a fantastic PhD student with Dan, led this "phylo-functional" work & uncovered complex duplication & loss of a glucosinolate gene across the Brassicaceae affecting enantiomeric specificity
Amanda, a fantastic PhD student with Dan, led this "phylo-functional" work & uncovered complex duplication & loss of a glucosinolate gene across the Brassicaceae affecting enantiomeric specificity
Convergence and constraint in glucosinolate evolution across the Brassicaceae
Studying a glucosinolate enzyme across the Brassicaceae shows evolution of plant specialized metabolism involves independent gene losses, distal duplicatio
academic.oup.com
November 13, 2025 at 4:01 PM
Happy to see this paper from my time with @spicybotrytis.bsky.social out in @theplantcell.bsky.social!
Amanda, a fantastic PhD student with Dan, led this "phylo-functional" work & uncovered complex duplication & loss of a glucosinolate gene across the Brassicaceae affecting enantiomeric specificity
Amanda, a fantastic PhD student with Dan, led this "phylo-functional" work & uncovered complex duplication & loss of a glucosinolate gene across the Brassicaceae affecting enantiomeric specificity
Reposted by Conchi Manzano
Please share & RSVP to join the November 25th webinar!
Hear from the 2025 Philip N. Benfey Arabidopsis Community Lifetime Achievement Awardees! bit.ly/naascawards
@plantevolution.bsky.social
Hear from the 2025 Philip N. Benfey Arabidopsis Community Lifetime Achievement Awardees! bit.ly/naascawards
@plantevolution.bsky.social
September 22, 2025 at 10:03 PM
Please share & RSVP to join the November 25th webinar!
Hear from the 2025 Philip N. Benfey Arabidopsis Community Lifetime Achievement Awardees! bit.ly/naascawards
@plantevolution.bsky.social
Hear from the 2025 Philip N. Benfey Arabidopsis Community Lifetime Achievement Awardees! bit.ly/naascawards
@plantevolution.bsky.social
Reposted by Conchi Manzano
Fresh from the press! For suberin lovers!
Work led by @, my former PhD student and now postdoc in the team, with help of @sarahorvath.bsky.social and in collaboration with @tonnigrubeandersen.bsky.social .
🔗 DOI: doi.org/10.1016/j.ce...
1/4 #PlantScience
Work led by @, my former PhD student and now postdoc in the team, with help of @sarahorvath.bsky.social and in collaboration with @tonnigrubeandersen.bsky.social .
🔗 DOI: doi.org/10.1016/j.ce...
1/4 #PlantScience
July 24, 2025 at 7:25 PM
Fresh from the press! For suberin lovers!
Work led by @, my former PhD student and now postdoc in the team, with help of @sarahorvath.bsky.social and in collaboration with @tonnigrubeandersen.bsky.social .
🔗 DOI: doi.org/10.1016/j.ce...
1/4 #PlantScience
Work led by @, my former PhD student and now postdoc in the team, with help of @sarahorvath.bsky.social and in collaboration with @tonnigrubeandersen.bsky.social .
🔗 DOI: doi.org/10.1016/j.ce...
1/4 #PlantScience
Reposted by Conchi Manzano
At long last, our paper on conservation and divergence of a nitrogen circuit upstream of NLP6/7 &NIR1 in Arabidopsis and tomato is published! It's an exciting combo of whole plant, in vitro, protoplast and systems bio approaches: tinyurl.com/nitrogencirc... @gozdedemirel.bsky.social
Conservation and divergence of regulatory architecture in nitrate-responsive plant gene circuits
Gene circuits that control transcriptional regulation of nitrate-responses have similarities and differences, despite the equivalent effects of nitrogen on
tinyurl.com
July 1, 2025 at 6:59 PM
At long last, our paper on conservation and divergence of a nitrogen circuit upstream of NLP6/7 &NIR1 in Arabidopsis and tomato is published! It's an exciting combo of whole plant, in vitro, protoplast and systems bio approaches: tinyurl.com/nitrogencirc... @gozdedemirel.bsky.social
Reposted by Conchi Manzano
Excited that our paper with @bradylabs.bsky.social on conservation and divergence in nitrogen regulatory networks is finally published. This was a fun & rewarding collaboration that will continue in new projects to engineer 🍅 N responses academic.oup.com/plcell/artic...
Conservation and divergence of regulatory architecture in nitrate-responsive plant gene circuits
Gene circuits that control transcriptional regulation of nitrate-responses have similarities and differences, despite the equivalent effects of nitrogen on
academic.oup.com
July 4, 2025 at 3:19 PM
Excited that our paper with @bradylabs.bsky.social on conservation and divergence in nitrogen regulatory networks is finally published. This was a fun & rewarding collaboration that will continue in new projects to engineer 🍅 N responses academic.oup.com/plcell/artic...
Reposted by Conchi Manzano
How plants sense injury in their barrier tissue, periderm? Painstakingly detailed and amazing work by post doc Hiroyuki Iida shows that wounding is sensed by the diffusion of two gases: ethylene and oxygen. @treebiocoe.bsky.social @erc.europa.eu 1/x 🧵 www.nature.com/articles/s41...
Plants monitor the integrity of their barrier by sensing gas diffusion - Nature
A study using Arabidopsis shows that plants can monitor the integrity of their outer barriers by sensing gas diffusion, enabling them to initiate wound repair to prevent water loss and pathogen entry.
www.nature.com
July 2, 2025 at 4:20 PM
How plants sense injury in their barrier tissue, periderm? Painstakingly detailed and amazing work by post doc Hiroyuki Iida shows that wounding is sensed by the diffusion of two gases: ethylene and oxygen. @treebiocoe.bsky.social @erc.europa.eu 1/x 🧵 www.nature.com/articles/s41...
Reposted by Conchi Manzano
Terrific rallying cry of an @socdevbio.bsky.social award lecture from @mads100tist.bsky.social at #icdb2025! Our work and community are important, #DevBio matters, and it’s up to us to tell everyone why. Don’t give the enshittifiers an inch!
June 22, 2025 at 6:30 PM
Terrific rallying cry of an @socdevbio.bsky.social award lecture from @mads100tist.bsky.social at #icdb2025! Our work and community are important, #DevBio matters, and it’s up to us to tell everyone why. Don’t give the enshittifiers an inch!
Reposted by Conchi Manzano
Time for another paper from our lab!
This time it’s about passage cells. This work originated from a collaboration with @lauraragni.bsky.social and was spearheaded by the super-talented @leoniekraska.bsky.social Below you will find a thread that explains our findings.
www.cell.com/cell-reports...
This time it’s about passage cells. This work originated from a collaboration with @lauraragni.bsky.social and was spearheaded by the super-talented @leoniekraska.bsky.social Below you will find a thread that explains our findings.
www.cell.com/cell-reports...
MYB68 regulates radial endodermal differentiation and suberin patterning
In this study, Kraska et al. identify MYB68 as a novel regulator of endodermal suberization,
linked to the formation of distinct identities in the xylem-pole-associated endodermis.
The research uncove...
www.cell.com
June 9, 2025 at 7:02 AM
Time for another paper from our lab!
This time it’s about passage cells. This work originated from a collaboration with @lauraragni.bsky.social and was spearheaded by the super-talented @leoniekraska.bsky.social Below you will find a thread that explains our findings.
www.cell.com/cell-reports...
This time it’s about passage cells. This work originated from a collaboration with @lauraragni.bsky.social and was spearheaded by the super-talented @leoniekraska.bsky.social Below you will find a thread that explains our findings.
www.cell.com/cell-reports...
Reposted by Conchi Manzano
Our work on MYBs and WRKY regulating suberin in tomato exodermis is now out in @jxbotany.bsky.social!
🍅 doi.org/10.1093/jxb/...
👩🔬 @leonardojo.bsky.social @riannekluck.bsky.social @marianasartur.bsky.social Sara Buti, Alex Cantó-Pastor @bradylabs.bsky.social
🌱 #PlantScience
🍅 doi.org/10.1093/jxb/...
👩🔬 @leonardojo.bsky.social @riannekluck.bsky.social @marianasartur.bsky.social Sara Buti, Alex Cantó-Pastor @bradylabs.bsky.social
🌱 #PlantScience
May 1, 2025 at 9:17 AM
Our work on MYBs and WRKY regulating suberin in tomato exodermis is now out in @jxbotany.bsky.social!
🍅 doi.org/10.1093/jxb/...
👩🔬 @leonardojo.bsky.social @riannekluck.bsky.social @marianasartur.bsky.social Sara Buti, Alex Cantó-Pastor @bradylabs.bsky.social
🌱 #PlantScience
🍅 doi.org/10.1093/jxb/...
👩🔬 @leonardojo.bsky.social @riannekluck.bsky.social @marianasartur.bsky.social Sara Buti, Alex Cantó-Pastor @bradylabs.bsky.social
🌱 #PlantScience
Reposted by Conchi Manzano
Thrilled to see our work now online @nature.com
This study reveals how individual root cells sense and respond to real, compacted soil environments.
www.nature.com/articles/s41...
beautiful spatial transcritomics of rice root in gel & soil conditions and huge credit to Mingyuan and colleagues.
This study reveals how individual root cells sense and respond to real, compacted soil environments.
www.nature.com/articles/s41...
beautiful spatial transcritomics of rice root in gel & soil conditions and huge credit to Mingyuan and colleagues.
May 1, 2025 at 9:43 AM
Thrilled to see our work now online @nature.com
This study reveals how individual root cells sense and respond to real, compacted soil environments.
www.nature.com/articles/s41...
beautiful spatial transcritomics of rice root in gel & soil conditions and huge credit to Mingyuan and colleagues.
This study reveals how individual root cells sense and respond to real, compacted soil environments.
www.nature.com/articles/s41...
beautiful spatial transcritomics of rice root in gel & soil conditions and huge credit to Mingyuan and colleagues.
Reposted by Conchi Manzano
Spatial transcriptomic imaging of an intact organism using volumetric DNA microscopy www.nature.com/articles/s41...
Spatial transcriptomic imaging of an intact organism using volumetric DNA microscopy - Nature Biotechnology
Volumetric DNA microscopy captures spatial information of RNA within an intact organism.
www.nature.com
March 27, 2025 at 7:31 PM
Spatial transcriptomic imaging of an intact organism using volumetric DNA microscopy www.nature.com/articles/s41...
Reposted by Conchi Manzano
Finally!
Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course).
www.science.org/doi/10.1126/...
Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course).
www.science.org/doi/10.1126/...
Apoplastic barriers are essential for nodule formation and nitrogen fixation in Lotus japonicus
Establishment of the apoplastic root barrier known as the Casparian strip occurs early in root development. In legumes, this area overlaps with nitrogen-fixing nodule formation, which raises the possi...
www.science.org
March 21, 2025 at 5:53 AM
Finally!
Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course).
www.science.org/doi/10.1126/...
Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course).
www.science.org/doi/10.1126/...
Reposted by Conchi Manzano
and we thought auxin signalling was "kind of solved"..
TIR1-produced cAMP is essential for auxin response (in Arabidopsis thaliana) 🔽
www.nature.com/articles/s41...
TIR1-produced cAMP is essential for auxin response (in Arabidopsis thaliana) 🔽
www.nature.com/articles/s41...
TIR1-produced cAMP as a second messenger in transcriptional auxin signalling - Nature
cAMP produced by the TIR1/AFB receptors of the main endogenous developmental plant hormone auxin acts as a true second messenger, revising the established paradigm of transcriptional auxin signalling.
www.nature.com
March 5, 2025 at 9:32 PM
and we thought auxin signalling was "kind of solved"..
TIR1-produced cAMP is essential for auxin response (in Arabidopsis thaliana) 🔽
www.nature.com/articles/s41...
TIR1-produced cAMP is essential for auxin response (in Arabidopsis thaliana) 🔽
www.nature.com/articles/s41...
Reposted by Conchi Manzano
We are hiring! Are you interested in lateral root development and the cellular processes that accommodate these newly formed organs? If yes, apply! We are recruiting a Post-doc (from May 2025) and a PhD student (from September 2025).
www.unine.ch/lbmc/jobs/
www.unine.ch/lbmc/jobs/
Jobs - Laboratory of cell and molecular biology
Join Our Team – Open Positions at the LBMC, Vermeer Lab. We are excited to announce two open positions, please get in touch with Prof. Dr. Joop Vermeer: josephus.vermeer@unine.ch Applications open f...
www.unine.ch
February 26, 2025 at 3:37 PM
We are hiring! Are you interested in lateral root development and the cellular processes that accommodate these newly formed organs? If yes, apply! We are recruiting a Post-doc (from May 2025) and a PhD student (from September 2025).
www.unine.ch/lbmc/jobs/
www.unine.ch/lbmc/jobs/
Reposted by Conchi Manzano
I am really proud to share our study on microbes, Striga and sorghum is now online in Cell Reports! doi.org/10.1016/j.ce... and the press release is here: biology.ucdavis.edu/news/soil-mi... This was an epic effort led by the incredible Dorota Kawa, +B. Thiombiano, H. Bouwmeester, J. Raiijmakers...
Redirecting
doi.org
March 27, 2024 at 6:13 PM
I am really proud to share our study on microbes, Striga and sorghum is now online in Cell Reports! doi.org/10.1016/j.ce... and the press release is here: biology.ucdavis.edu/news/soil-mi... This was an epic effort led by the incredible Dorota Kawa, +B. Thiombiano, H. Bouwmeester, J. Raiijmakers...
Reposted by Conchi Manzano
I am so excited to share Dr. C Manzano’s work: she demonstrates the developmental timeline, function and genetic regulation of the polar lignin cap in the tomato root. It functions as a distinct intercellular barrier from the Casparian strip and is repressed in inner layers. rdcu.be/d10Pd
December 3, 2024 at 10:58 AM
I am so excited to share Dr. C Manzano’s work: she demonstrates the developmental timeline, function and genetic regulation of the polar lignin cap in the tomato root. It functions as a distinct intercellular barrier from the Casparian strip and is repressed in inner layers. rdcu.be/d10Pd