Manojit Swamynathan
@manojitswamynathan.bsky.social
Cancer Biologist @ CSHL
Reposted by Manojit Swamynathan
www.nature.com/articles/s41...
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy - Nature
Acetyl-coenzyme A functions as a non-canonical signal to trigger mitophagy, and the acetyl-coenzyme A–NLRX1 axis underlies the KRAS-inhibitor-induced mitophagy response and promotes drug resistan...
www.nature.com
November 12, 2025 at 6:02 PM
www.nature.com/articles/s41...
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Reposted by Manojit Swamynathan
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...
Termination of the integrated stress response
Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by p...
www.science.org
November 13, 2025 at 7:05 PM
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...
Reposted by Manojit Swamynathan
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis: Cell www.cell.com/cell/fulltex...
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by
the synergy of innate immune activation and metabolic stress. This process is regulated
by mTORC2 and involves persis...
www.cell.com
December 2, 2025 at 4:39 PM
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis: Cell www.cell.com/cell/fulltex...
Reposted by Manojit Swamynathan
Good morning, all. A great selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"Calm down. Both your sins and your good deeds will be lost in oblivion." - Czesław Miłosz
"Calm down. Both your sins and your good deeds will be lost in oblivion." - Czesław Miłosz
November 30, 2025 at 6:22 AM
Good morning, all. A great selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"Calm down. Both your sins and your good deeds will be lost in oblivion." - Czesław Miłosz
"Calm down. Both your sins and your good deeds will be lost in oblivion." - Czesław Miłosz
Reposted by Manojit Swamynathan
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...
www.science.org
October 10, 2025 at 11:05 AM
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...
Reposted by Manojit Swamynathan
TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors: Cancer Cell www.cell.com/cancer-cell/...
TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors
Herbrich et al. demonstrate that TET2-mutant clonal hematopoiesis improves response
to immune checkpoint therapy in the context of solid tumors. Intratumoral TET2-mutant
macrophages are immunogenic an...
www.cell.com
October 16, 2025 at 4:31 PM
TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors: Cancer Cell www.cell.com/cancer-cell/...
Reposted by Manojit Swamynathan
The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
September 20, 2025 at 7:43 AM
The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Reposted by Manojit Swamynathan
New work from our own Chouchani Lab finds that LRRC58 is the substrate adaptor of an E3 ubiquitin ligase that mediates proteasomal degradation of CDO1, the rate-limiting enzyme of the catabolic shunt of cysteine to taurine in response to altered Cysteine levels. www.nature.com/articles/s41...
Covariation MS uncovers a protein that controls cysteine catabolism - Nature
A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.
www.nature.com
September 17, 2025 at 5:48 PM
New work from our own Chouchani Lab finds that LRRC58 is the substrate adaptor of an E3 ubiquitin ligase that mediates proteasomal degradation of CDO1, the rate-limiting enzyme of the catabolic shunt of cysteine to taurine in response to altered Cysteine levels. www.nature.com/articles/s41...
Reposted by Manojit Swamynathan
Reposted by Manojit Swamynathan
www.nature.com/articles/s41...
Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry
Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry
Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry - Nature
APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.
www.nature.com
July 30, 2025 at 3:59 PM
www.nature.com/articles/s41...
Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry
Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry
Reposted by Manojit Swamynathan
Mitochondrial glutathione import enables breast cancer metastasis via integrated stress response signaling url: aacrjournals.org/cancerdiscov...
Cool work from the Birsoy lab!
Cool work from the Birsoy lab!
Mitochondrial glutathione import enables breast cancer metastasis via integrated stress response signaling
Abstract. Cancer cells require substantial metabolic adaptations to metastasize to distant organs, but the metabolites essential for successful colonization remain poorly defined. Here, we used a mito...
aacrjournals.org
August 3, 2025 at 6:09 AM
Mitochondrial glutathione import enables breast cancer metastasis via integrated stress response signaling url: aacrjournals.org/cancerdiscov...
Cool work from the Birsoy lab!
Cool work from the Birsoy lab!
Reposted by Manojit Swamynathan
Happy to start at Bluesky with a post on our recent manuscript at @nature.com:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature
17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.
www.nature.com
August 19, 2025 at 8:57 AM
Happy to start at Bluesky with a post on our recent manuscript at @nature.com:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
Reposted by Manojit Swamynathan
Reposted by Manojit Swamynathan
Nature research paper: EndoMAP.v1 charts the structural landscape of human early endosome complexes
https://go.nature.com/3Z6mJ1X
https://go.nature.com/3Z6mJ1X
EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature
A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.
go.nature.com
June 4, 2025 at 7:59 AM
Nature research paper: EndoMAP.v1 charts the structural landscape of human early endosome complexes
https://go.nature.com/3Z6mJ1X
https://go.nature.com/3Z6mJ1X
Reposted by Manojit Swamynathan
Reposted by Manojit Swamynathan
Reposted by Manojit Swamynathan
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury: Cell Metabolism www.cell.com/cell-metabol...
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury
Novak et al. discover that dietary serine impacts whether hair follicle stem cells
(HFSCs) prioritize hair growth or skin repair after injury. HFSCs gauge metabolic
stress using the ISR and accelerate...
www.cell.com
June 12, 2025 at 2:59 PM
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury: Cell Metabolism www.cell.com/cell-metabol...