Manideep Chavali
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manideep.bsky.social
Manideep Chavali
@manideep.bsky.social
180 followers 310 following 0 posts
Assistant Professor @ OHSU 🧠 | Neuroscientist: OPCs, vessels & brain mysteries. #newPI
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Reposted by Manideep Chavali
siegenthalerlab.bsky.social
Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
Micrscopy images of cleared cerebral brain tissue showing penetrating blood vessels (white) in mice - magenta cells are perivascular fibroblasts and cyan cells are perivascular macrophages - in control mice, both cell types are near the vessel termini by postnatal day 10 but in 'cKO' mice that lack expression of a tyrosine kinase receptor PDGFRa in fibroblasts, both the fibroblasts and macrophages are only partially covering the vessels. From Figure 4 of our paper - https://authors.elsevier.com/a/1m7fa2mzTkyfS
November 20, 2025 at 1:23 PM
Reposted by Manideep Chavali
auroralkraus.bsky.social
Check out our recent preprint, "Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish."

lnkd.in/gN7z6th4
November 18, 2025 at 2:42 AM
Reposted by Manideep Chavali
ppimentel-coelho.bsky.social
Obituary: Jose Manuel García-Verdugo (1954–2025), an Exceptional Eye Into the Fine Structure of the Brain's Germinal Centers

Arantxa Cebrian-Silla, Mercedes Paredes, Arturo Alvarez-Buylla

onlinelibrary.wiley.com/doi/10.1002/...
Obituary: Jose Manuel García‐Verdugo (1954–2025), an Exceptional Eye Into the Fine Structure of the Brain's Germinal Centers
Click on the article title to read more.
onlinelibrary.wiley.com
November 14, 2025 at 8:16 PM
Reposted by Manideep Chavali
sheckyfeinblatt.bsky.social
Our postdoc ad is up on the SDB website! Come to Portland and study regenerative neurogenesis in planarians and zebrafish:
www.sdbonline.org/resource?Res...
Society for Developmental Biology | Resource
www.sdbonline.org
September 5, 2025 at 4:11 PM
Reposted by Manideep Chavali
nature.com
Nature research paper: Axonal injury is a targetable driver of glioblastoma progression

go.nature.com/4lFmpiN
Axonal injury is a targetable driver of glioblastoma progression - Nature
Axonal injury, induced in the white matter by expansion of early tumour cells, is a key driver of glioblastoma progression.
go.nature.com
August 20, 2025 at 3:48 PM
Reposted by Manideep Chavali
blacoste.bsky.social
Another beautiful study by the lab of @andyshihlab.bsky.social published today in @natureportfolio.nature.com 👏🏻👏🏻👏🏻 #cerebrovascular #aging
Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging - Nature Neuroscience
How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capi...
doi.org
August 12, 2025 at 9:12 PM
Reposted by Manideep Chavali
ardemp.bskyverified.social
Fantastic new study on the role of TMEM63a in oligodendrocyte-dependent myelination in the CNS from the Swetha Murthy lab: pubmed.ncbi.nlm.nih.gov/40694323/
TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination - PubMed
Infantile hypomyelinating leukodystrophy 19 (HLD19) is a rare genetic disorder where patients exhibit reduced myelin in central nervous system (CNS) white matter tracts and present with varied neurolo...
pubmed.ncbi.nlm.nih.gov
July 24, 2025 at 6:21 PM
Reposted by Manideep Chavali
blacoste.bsky.social
#Cerebrovascular #Neurovascular
Reduction of neuronal activity mediated by blood-vessel regression in the adult brain - Nature Communications
The role of vascular plasticity in brain function remains poorly understood. Here, the authors demonstrate that a significant portion of blood vessels in the adult brain periodically occlude and regre...
www.nature.com
July 2, 2025 at 2:54 AM
Reposted by Manideep Chavali
biorxiv-neursci.bsky.social
Directional growth of developing myelin mediated by Wnt gradient and required for proper axon functions https://www.biorxiv.org/content/10.1101/2025.06.13.659097v1
June 15, 2025 at 8:15 AM
Reposted by Manideep Chavali
lyons-lab.bsky.social
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker

www.nature.com/articles/s41...
Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience
Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...
www.nature.com
May 14, 2025 at 11:45 AM
Reposted by Manideep Chavali
ethanhugheslab.bsky.social
New paper out from the lab! Led by @gdfnunes.bsky.social and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠

www.nature.com/articles/s41...
Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function - Nature Communications
Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination deficits and accelerated n...
www.nature.com
January 18, 2025 at 6:41 PM
Reposted by Manideep Chavali
biorxiv-neursci.bsky.social
Genetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal Activity https://www.biorxiv.org/content/10.1101/2024.12.27.630559v1
December 28, 2024 at 8:16 AM