Maddalena Marasà
@madmarasa.bsky.social
Nephrologist & Researcher, Clinical Research Center for Rare Diseases "Aldo e Cele Daccò", Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy
Opinions are my own
#kidneydisease #raredisease #genetics #glomerulardisease
Opinions are my own
#kidneydisease #raredisease #genetics #glomerulardisease
Reposted by Maddalena Marasà
Today is #C3GAwarenessDay! At ISGD, we stand with people living with this rare kidney disease. As a medical society for #GlomerularDisease experts, we're committed to raising awareness and moving the science forward to bring more hope and solutions to the C3G community. #C3G #ISGD
September 25, 2025 at 3:34 PM
Today is #C3GAwarenessDay! At ISGD, we stand with people living with this rare kidney disease. As a medical society for #GlomerularDisease experts, we're committed to raising awareness and moving the science forward to bring more hope and solutions to the C3G community. #C3G #ISGD
This is so shameful…
After revoking contested appointments to Italy's National Immunization Technical Advisory Group, experts warn the episode signals wider risks for evidence-based policy and Italy's role in global health.
Find out more in a new World Report: tinyurl.com/3j6md7tn
Find out more in a new World Report: tinyurl.com/3j6md7tn
August 31, 2025 at 7:09 PM
This is so shameful…
Reposted by Maddalena Marasà
Fresh online on @natcomms.nature.com ! Great collaboration with the lead team at GharaviLab / CPMG.
Large exome-wide analysis that points to many findings, including two novel genes: ARID3A and NR6A1.
#CAKUT #humangenetics #development #pediatrics #NephSky #SkyNeph
www.nature.com/articles/s41...
Large exome-wide analysis that points to many findings, including two novel genes: ARID3A and NR6A1.
#CAKUT #humangenetics #development #pediatrics #NephSky #SkyNeph
www.nature.com/articles/s41...
Exome analysis links kidney malformations to developmental disorders and reveals causal genes - Nature Communications
The authors analyze rare coding variants in 1990 individuals with congenital kidney anomalies, finding diagnostic variants in 14.1% of cases. They identify two new causal genes, ARID3A and NR6A1, alon...
www.nature.com
August 7, 2025 at 7:13 PM
Fresh online on @natcomms.nature.com ! Great collaboration with the lead team at GharaviLab / CPMG.
Large exome-wide analysis that points to many findings, including two novel genes: ARID3A and NR6A1.
#CAKUT #humangenetics #development #pediatrics #NephSky #SkyNeph
www.nature.com/articles/s41...
Large exome-wide analysis that points to many findings, including two novel genes: ARID3A and NR6A1.
#CAKUT #humangenetics #development #pediatrics #NephSky #SkyNeph
www.nature.com/articles/s41...
Wow! Second approved drug for an ultrarare disease in a few months, and with broader indication. What a milestone!
Time for EMA’s approval now.
#raredisease #glomerulardisease #c3g #nephSky
Time for EMA’s approval now.
#raredisease #glomerulardisease #c3g #nephSky
⚠️ The FDA has approved pegcetacoplan (Empaveli) for treating C3G and IC-MPGN. #kidneydisease #nephrology #nephsky #c3g www.docwirenews.com/post/fda-app...
FDA Approves Pegcetacoplan for C3G and IC-MPGN | Docwire News
The FDA approved pegcetacoplan for treating C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN in patients age 12 and older.
www.docwirenews.com
August 2, 2025 at 8:21 AM
Wow! Second approved drug for an ultrarare disease in a few months, and with broader indication. What a milestone!
Time for EMA’s approval now.
#raredisease #glomerulardisease #c3g #nephSky
Time for EMA’s approval now.
#raredisease #glomerulardisease #c3g #nephSky
Very remarkable long-term outcomes and safety profile for one of the first mAbs ever used in glomerular diseases
#glomerulardiseases #rarediseases #nephSky
#glomerulardiseases #rarediseases #nephSky
Long-term Outcome of #Adult Patients With #Membranous Nephropathy Treated With #Rituximab
#VisualAbstract by @priti899.bsky.social
www.kireports.org/ar...
#VisualAbstract by @priti899.bsky.social
www.kireports.org/ar...
July 14, 2025 at 9:13 PM
Very remarkable long-term outcomes and safety profile for one of the first mAbs ever used in glomerular diseases
#glomerulardiseases #rarediseases #nephSky
#glomerulardiseases #rarediseases #nephSky
Reposted by Maddalena Marasà
To do or not to do—genetic testing for autosomal dominant polycystic kidney disease in children and adolescents
doi.org/10.1016/j.kint.2025.05.001
Original article: doi.org/10.1016/j.kint.2025.02.026
#KICommentary #NephSky #MedSky #ADPKD
doi.org/10.1016/j.kint.2025.05.001
Original article: doi.org/10.1016/j.kint.2025.02.026
#KICommentary #NephSky #MedSky #ADPKD
July 14, 2025 at 1:06 PM
To do or not to do—genetic testing for autosomal dominant polycystic kidney disease in children and adolescents
doi.org/10.1016/j.kint.2025.05.001
Original article: doi.org/10.1016/j.kint.2025.02.026
#KICommentary #NephSky #MedSky #ADPKD
doi.org/10.1016/j.kint.2025.05.001
Original article: doi.org/10.1016/j.kint.2025.02.026
#KICommentary #NephSky #MedSky #ADPKD
Reposted by Maddalena Marasà
Today’s Daily Cartoon, by Paul Noth. #NewYorkerCartoons
Sign up for our humor newsletter to never miss a Daily Cartoon: nyer.cm/kyxchAh
Sign up for our humor newsletter to never miss a Daily Cartoon: nyer.cm/kyxchAh
July 14, 2025 at 6:02 PM
Today’s Daily Cartoon, by Paul Noth. #NewYorkerCartoons
Sign up for our humor newsletter to never miss a Daily Cartoon: nyer.cm/kyxchAh
Sign up for our humor newsletter to never miss a Daily Cartoon: nyer.cm/kyxchAh
Reposted by Maddalena Marasà
President Trump claims the US strike on Iran was a "spectacular military success." We'll see. What we do know is that Trump has pushed the US into a new war in the Middle East with considerable risks of escalation. Here are the risks I'm concerned about: www.nytimes.com/2025/06/22/o...
June 22, 2025 at 5:16 AM
President Trump claims the US strike on Iran was a "spectacular military success." We'll see. What we do know is that Trump has pushed the US into a new war in the Middle East with considerable risks of escalation. Here are the risks I'm concerned about: www.nytimes.com/2025/06/22/o...
Kidney health finally prioritized in the WHO noncommunicable disease agenda!
#kidneyhealthmatters #nephsky #medsky
#kidneyhealthmatters #nephsky #medsky
🌍 History made! For the first time, kidney care is on the global health agenda. #WHA78 adopted a landmark resolution recognizing kidney health in the fight against #NCDs.
👏 Thanks to Guatemala and the global kidney community for making this possible!
#KidneyHealthMatters
👏 Thanks to Guatemala and the global kidney community for making this possible!
#KidneyHealthMatters
May 23, 2025 at 3:06 PM
Kidney health finally prioritized in the WHO noncommunicable disease agenda!
#kidneyhealthmatters #nephsky #medsky
#kidneyhealthmatters #nephsky #medsky
Reposted by Maddalena Marasà
In a new publication, Drs. Steers, Gharavi and colleagues performed genetic and immunological studies of IgA nephropathy and demonstrated a new role of aberrant O-glycosylation in the pathogenesis of IgA Nephropathy. Read more here:
www.jci.org/articles/vie...
www.jci.org/articles/vie...
JCI -
Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy
www.jci.org
May 22, 2025 at 2:45 PM
In a new publication, Drs. Steers, Gharavi and colleagues performed genetic and immunological studies of IgA nephropathy and demonstrated a new role of aberrant O-glycosylation in the pathogenesis of IgA Nephropathy. Read more here:
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Increased risk of developing #kidneydisease in offspring exposed to maternal preeclampsia independently from preterm birth?
#nephsky #medsky
#nephsky #medsky
A nationwide register-based cohort study examined the association between #preeclampsia in mothers and the risk of #kidneydisease in their offspring
doi.org/10.1016/j.kint.2025.04.017
#OpenAccess #chronickidneydisease #CKD #Glomerulonephritis #PedsNeph #NephSky #MedSky #diabeticnephropathy
doi.org/10.1016/j.kint.2025.04.017
#OpenAccess #chronickidneydisease #CKD #Glomerulonephritis #PedsNeph #NephSky #MedSky #diabeticnephropathy
May 20, 2025 at 9:12 PM
Increased risk of developing #kidneydisease in offspring exposed to maternal preeclampsia independently from preterm birth?
#nephsky #medsky
#nephsky #medsky
Scientific progress grows out of freedom. As a society, we must stand with scientists and speak out against restrictions on scientific freedom and funding - we are all in this together.
www.nature.com/articles/d41...
www.science.org/content/arti...
www.nature.com/articles/d41...
www.science.org/content/arti...
May 14, 2025 at 11:41 AM
Scientific progress grows out of freedom. As a society, we must stand with scientists and speak out against restrictions on scientific freedom and funding - we are all in this together.
www.nature.com/articles/d41...
www.science.org/content/arti...
www.nature.com/articles/d41...
www.science.org/content/arti...
Alternative complement pathway dysregulation in CKD and CKD progression, endothelial inflammation and cardiovascular outcomes… room for complement inhibitors beyond complement-mediated kidney diseases?
www.jci.org/articles/vie...
#NephSky #MedSky
www.jci.org/articles/vie...
#NephSky #MedSky
Aberrant activation of complement's alternative pathway may be the missing link in understanding how vascular and systemic inflammation accelerates chronic kidney disease progression.
Read more in the review by Jalal, Thurman & Smith: buff.ly/DwHd0ut
Read more in the review by Jalal, Thurman & Smith: buff.ly/DwHd0ut
May 6, 2025 at 11:02 PM
Alternative complement pathway dysregulation in CKD and CKD progression, endothelial inflammation and cardiovascular outcomes… room for complement inhibitors beyond complement-mediated kidney diseases?
www.jci.org/articles/vie...
#NephSky #MedSky
www.jci.org/articles/vie...
#NephSky #MedSky
Reposted by Maddalena Marasà
Hey I know these people! Check out this paper👇
Glucocorticoid Exposure and Infection in Children and Adults With Glomerular Disease: Findings From the Cure Glomerulonephropathy Study
bit.ly/3DHbXai (FREE)
bit.ly/3DHbXai (FREE)
April 24, 2025 at 2:28 AM
Hey I know these people! Check out this paper👇
Reposted by Maddalena Marasà
After Trump’s first 100 days, agency scientists say U.S. health institutes are demoralized and have lost essential staff and funding.
NIH insiders: Trump is ‘dismantling and destroying everything'
After just 100 days, agency scientists say U.S. health institutes are demoralized and have lost essential staff and funding
scim.ag
April 30, 2025 at 9:56 PM
After Trump’s first 100 days, agency scientists say U.S. health institutes are demoralized and have lost essential staff and funding.
I have never seen anything like this in NYC. 5th Ave covered from 42nd St well to the 20s. Nobody prepared for this volume. Volunteers are holding the traffic on all the side streets. No police in sight. #handsoff
April 6, 2025 at 12:31 AM
Reposted by Maddalena Marasà
Public health, biomedical science, and the well being of Americans will be worse off for this week's devastating cuts at HHS. My latest for @opinion.bloomberg.com (gift link):
This Isn’t How You Make America Healthy Again
Gutting the public health agencies that keep Americans safe — and not being transparent about it — will cause harm that can’t easily be reversed.
www.bloomberg.com
April 3, 2025 at 1:00 PM
Public health, biomedical science, and the well being of Americans will be worse off for this week's devastating cuts at HHS. My latest for @opinion.bloomberg.com (gift link):
"The strategy of not speaking up out of fear is not working"
@lisamjarvis.bsky.social calls Big pharma to mobilize and support federally funded research and drug evaluation - both engines of most innovation biotech and pharma companies develop.
@lisamjarvis.bsky.social calls Big pharma to mobilize and support federally funded research and drug evaluation - both engines of most innovation biotech and pharma companies develop.
Noticeably silent amid the upheaval at HHS? Big pharma. Every new drug has NIH somewhere in its DNA--and NIH funding supports the training of their workforce. Now they're finding out FDA isn't safe, either. Wrote about how keeping quiet isn't working My latest @opinion.bloomberg.com (gift link):
Big Pharma Needs to Get Off the Sidelines
The industry can’t continue to sit idly by while Robert F. Kennedy Jr. guts the nation’s public health agencies.
www.bloomberg.com
April 1, 2025 at 10:00 PM
"The strategy of not speaking up out of fear is not working"
@lisamjarvis.bsky.social calls Big pharma to mobilize and support federally funded research and drug evaluation - both engines of most innovation biotech and pharma companies develop.
@lisamjarvis.bsky.social calls Big pharma to mobilize and support federally funded research and drug evaluation - both engines of most innovation biotech and pharma companies develop.
Reposted by Maddalena Marasà
Finally, top scientists speak up against the Trump administration in a letter signed by 2,000 elected members of the National Academies of Sciences, Engineering, and Medicine: "the nation's scientific enterprise is being decimated"; see related NYT coverage here:
www.nytimes.com/2025/03/31/s...
www.nytimes.com/2025/03/31/s...
March 31, 2025 at 6:54 PM
Finally, top scientists speak up against the Trump administration in a letter signed by 2,000 elected members of the National Academies of Sciences, Engineering, and Medicine: "the nation's scientific enterprise is being decimated"; see related NYT coverage here:
www.nytimes.com/2025/03/31/s...
www.nytimes.com/2025/03/31/s...
Reposted by Maddalena Marasà
Beautiful, mechanistic work!
Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy www.jci.org/articles/vie...
Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy www.jci.org/articles/vie...
JCI -
Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy
www.jci.org
March 29, 2025 at 1:30 PM
Beautiful, mechanistic work!
Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy www.jci.org/articles/vie...
Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy www.jci.org/articles/vie...
Reposted by Maddalena Marasà
Transplantation of human kidney organoids elicited a robust allogeneic response in a humanized mouse model.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Transplantation of human kidney organoids elicited a robust allogeneic response in a humanized mouse model.
Human kidney organoids derived from embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) have become novel tools for studying various…
www.sciencedirect.com
March 25, 2025 at 9:24 PM
Transplantation of human kidney organoids elicited a robust allogeneic response in a humanized mouse model.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Columbia's "IgA Nephropathy Diagnosis & Treatment Updates 2025" on April 4th.
All the latest IgAN updates in one place with outstanding speakers!
@cuimcglomcenter.bsky.social
@cuimcmedicinedept.bsky.social
@jradnephro.bsky.social
@kirylukk.bsky.social
#Nephsky #glomerulardisease
All the latest IgAN updates in one place with outstanding speakers!
@cuimcglomcenter.bsky.social
@cuimcmedicinedept.bsky.social
@jradnephro.bsky.social
@kirylukk.bsky.social
#Nephsky #glomerulardisease
Happy Thursday! Around two weeks left to register for the IgAN Diagnosis & Treatment Updates 2025 on April 4th. Feel free to register using the following link: www.eventleaf.com/e/...
March 24, 2025 at 11:13 PM
Columbia's "IgA Nephropathy Diagnosis & Treatment Updates 2025" on April 4th.
All the latest IgAN updates in one place with outstanding speakers!
@cuimcglomcenter.bsky.social
@cuimcmedicinedept.bsky.social
@jradnephro.bsky.social
@kirylukk.bsky.social
#Nephsky #glomerulardisease
All the latest IgAN updates in one place with outstanding speakers!
@cuimcglomcenter.bsky.social
@cuimcmedicinedept.bsky.social
@jradnephro.bsky.social
@kirylukk.bsky.social
#Nephsky #glomerulardisease
Reposted by Maddalena Marasà
NEW editorial on what public health means under Trump 2.0
At The Lancet Public Health, it still means to stand for the communities we serve, to report, document, support researchers and practitioners, and advocate for better health for ALL.
Read #openaccess www.thelancet.com/journals/lan...
At The Lancet Public Health, it still means to stand for the communities we serve, to report, document, support researchers and practitioners, and advocate for better health for ALL.
Read #openaccess www.thelancet.com/journals/lan...
Public health under Trump 2.0: the first 50 days
Jan 20, 2025, US President Donald Trump took charge of the Oval Office and began by
signing an array of executive orders spanning from withdrawal from WHO and the Paris
Climate Agreement to freezing t...
www.thelancet.com
March 21, 2025 at 5:20 PM
NEW editorial on what public health means under Trump 2.0
At The Lancet Public Health, it still means to stand for the communities we serve, to report, document, support researchers and practitioners, and advocate for better health for ALL.
Read #openaccess www.thelancet.com/journals/lan...
At The Lancet Public Health, it still means to stand for the communities we serve, to report, document, support researchers and practitioners, and advocate for better health for ALL.
Read #openaccess www.thelancet.com/journals/lan...
Reposted by Maddalena Marasà
What is the impact of microplastics on human health? The latest episode of Beyond Journal Club, a collaboration between @coreimpodcast.bsky.social and NEJM Group, takes a deep dive into the APAChE study on microplastics and cardiovascular disease. 🎧 Listen here: nej.md/4igpJQy
#MedSky
#MedSky
March 18, 2025 at 7:30 PM
What is the impact of microplastics on human health? The latest episode of Beyond Journal Club, a collaboration between @coreimpodcast.bsky.social and NEJM Group, takes a deep dive into the APAChE study on microplastics and cardiovascular disease. 🎧 Listen here: nej.md/4igpJQy
#MedSky
#MedSky