Madeline Keenen
@madkeenen.bsky.social
Postdoc in the Gladfelter Lab studying nuclear dynamics of placenta cells. NCI K00 fellow, botanist, craft enthusiast. Message for info on past experiences!
Reposted by Madeline Keenen
Working on the cell biology of the nucleus? We're still accepting submissions for our special issue on this topic!
Find out more at:
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
Find out more at:
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
October 17, 2025 at 10:32 AM
Working on the cell biology of the nucleus? We're still accepting submissions for our special issue on this topic!
Find out more at:
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
Find out more at:
journals.biologists.com/jcs/pages/nu...
#cellbiology #nucleus #notforprofit #freetopublish
those small moments of optimism! The @gladfelterlab.bsky.social and Duke had a member of Thom Tillis's team visit the lab to talk about the bill, see the work we do, and meet the scientists behind it (on May 23rd oddly enough, the date on this letter). Would strongly recommend!
A big thanks to NC Sen. Thom Tillis for being the first signature on this bipartisan letter urging the Senate to maintain a strong commitment to funding for NIH in the Labor, Health and Human Services, and Education FY 2026 Appropriations bill. Is your Senator here?
www.aamc.org/research/adh...
www.aamc.org/research/adh...
June 25, 2025 at 1:27 PM
those small moments of optimism! The @gladfelterlab.bsky.social and Duke had a member of Thom Tillis's team visit the lab to talk about the bill, see the work we do, and meet the scientists behind it (on May 23rd oddly enough, the date on this letter). Would strongly recommend!
Sometimes it feels like my entire research portfolio has been inspired by electron microscopy images taken pre 1990. Thanks to #IFPA and Placenta for publishing this deep dive, it's dedicated to Drs Fox, Hamilton, Boyd, Burgos, Kaufmann and so many others! www.sciencedirect.com/science/arti...
June 19, 2025 at 3:50 PM
Sometimes it feels like my entire research portfolio has been inspired by electron microscopy images taken pre 1990. Thanks to #IFPA and Placenta for publishing this deep dive, it's dedicated to Drs Fox, Hamilton, Boyd, Burgos, Kaufmann and so many others! www.sciencedirect.com/science/arti...
Our paper FINALLY has a DOI, pre-print no-more. TLDR, the outer layer of the placenta is a single giant cell with billions of nuclei in a single common cytoplasm that can specialize their transcription in response to local environmental cues!
elifesciences.org/articles/101...
elifesciences.org/articles/101...
Comparative analysis of the syncytiotrophoblast in placenta tissue and trophoblast organoids using snRNA sequencing
Trophoblast organoids recapitulate syncytiotrophoblast nuclear heterogeneity and reveal environment-dependent gene regulation critical for placental hormone production and differentiation.
elifesciences.org
May 27, 2025 at 8:16 PM
Our paper FINALLY has a DOI, pre-print no-more. TLDR, the outer layer of the placenta is a single giant cell with billions of nuclei in a single common cytoplasm that can specialize their transcription in response to local environmental cues!
elifesciences.org/articles/101...
elifesciences.org/articles/101...
We resubmitted our paper this week! Raw data is available on GEO (GSE288650) and here's an interactive app we made so anyone can look up their favorite genes in our single nucleus placenta datasets gladfelterlab.shinyapps.io/PlacentaRNAs...
Placenta datasets from trophoblast organoids and primary human tissue
gladfelterlab.shinyapps.io
February 20, 2025 at 11:41 PM
We resubmitted our paper this week! Raw data is available on GEO (GSE288650) and here's an interactive app we made so anyone can look up their favorite genes in our single nucleus placenta datasets gladfelterlab.shinyapps.io/PlacentaRNAs...
Check out this article about our work on the most magical cell I know of in the human placenta! 😍 More details available in our reviewed preprint on eLife, and raw data should finally be available first thing in the new year.
elifesciences.org/reviewed-pre...
www.the-scientist.com/a-tissue-siz...
elifesciences.org/reviewed-pre...
www.the-scientist.com/a-tissue-siz...
A Tissue-Sized Cell with Billions of Nuclei
Single-nucleus RNA sequencing revealed specialized regions within the placenta's multinucleated cell.
www.the-scientist.com
December 5, 2024 at 2:12 PM
Check out this article about our work on the most magical cell I know of in the human placenta! 😍 More details available in our reviewed preprint on eLife, and raw data should finally be available first thing in the new year.
elifesciences.org/reviewed-pre...
www.the-scientist.com/a-tissue-siz...
elifesciences.org/reviewed-pre...
www.the-scientist.com/a-tissue-siz...
This seems like a timely moment to announce my eLife reviewed preprint is now online! @elife.bsky.social Can't say I'm too concerned about the 'impact factor' loss. BUT I do want to mention how positive of an experience it's been thus far..
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Comparative analysis of the syncytiotrophoblast in placenta tissue and trophoblast organoids using snRNA sequencing
elifesciences.org
November 14, 2024 at 4:43 PM
This seems like a timely moment to announce my eLife reviewed preprint is now online! @elife.bsky.social Can't say I'm too concerned about the 'impact factor' loss. BUT I do want to mention how positive of an experience it's been thus far..
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...