Lukas Frank
@lukfra.bsky.social
Postdoc in the Medema-Vader lab working on extrachromosomal DNA 🧬 | Prinses Máxima Center, Utrecht
🇪🇺 MSCA Fellow
🔬Former PhD in the Rippe lab | DKFZ & Heidelberg University
🇪🇺 MSCA Fellow
🔬Former PhD in the Rippe lab | DKFZ & Heidelberg University
Reposted by Lukas Frank
Why would anyone want to be a scientist?
Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...
Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...
August 15, 2025 at 1:19 PM
Why would anyone want to be a scientist?
Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...
Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...
Reposted by Lukas Frank
The appearance of large language models caused a drastic shift in the vocabulary of academic writing, according to an analysis in #ScienceAdvances of more than 15 million biomedical abstracts published from 2010 to 2024.
Learn more:
Learn more:
Delving into LLM-assisted writing in biomedical publications through excess vocabulary
Large language models (LLMs) like ChatGPT can generate and revise text with human-level performance. These models come with clear limitations, can produce inaccurate information, and reinforce existing biases.
scim.ag
August 10, 2025 at 2:07 PM
The appearance of large language models caused a drastic shift in the vocabulary of academic writing, according to an analysis in #ScienceAdvances of more than 15 million biomedical abstracts published from 2010 to 2024.
Learn more:
Learn more:
Reposted by Lukas Frank
Honoured to be awarded
Young Investigator Neuroscience Award from CHS Foundation together with my dearest David Brito for our paper in Molecular Psychiatry!
Curios about the work
⬇️⬇️⬇️ check out our paper & my 🧵 below
www.nature.com/articles/s41...
Young Investigator Neuroscience Award from CHS Foundation together with my dearest David Brito for our paper in Molecular Psychiatry!
Curios about the work
⬇️⬇️⬇️ check out our paper & my 🧵 below
www.nature.com/articles/s41...
July 14, 2025 at 3:18 PM
Honoured to be awarded
Young Investigator Neuroscience Award from CHS Foundation together with my dearest David Brito for our paper in Molecular Psychiatry!
Curios about the work
⬇️⬇️⬇️ check out our paper & my 🧵 below
www.nature.com/articles/s41...
Young Investigator Neuroscience Award from CHS Foundation together with my dearest David Brito for our paper in Molecular Psychiatry!
Curios about the work
⬇️⬇️⬇️ check out our paper & my 🧵 below
www.nature.com/articles/s41...
Reposted by Lukas Frank
How do transcription compartments form — and does phase separation drive gene expression? I enjoyed discussing these questions with @akispapantonis.bsky.social a lot, and we put our thoughts together for @naturerevgenet.bsky.social, now out at rdcu.be/erP1u
June 19, 2025 at 6:28 PM
How do transcription compartments form — and does phase separation drive gene expression? I enjoyed discussing these questions with @akispapantonis.bsky.social a lot, and we put our thoughts together for @naturerevgenet.bsky.social, now out at rdcu.be/erP1u
Reposted by Lukas Frank
Spotiflow, our deep learning based spot detection method for microscopy, is now published in @natmethods.nature.com!
Since the pre-print, we have added many features, notably native 3D detection!
@maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social
Paper: rdcu.be/epIB7
(1/N)
Since the pre-print, we have added many features, notably native 3D detection!
@maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social
Paper: rdcu.be/epIB7
(1/N)
Spotiflow: accurate and efficient spot detection for fluorescence microscopy with deep stereographic flow regression
Nature Methods - Spotiflow uses deep learning for subpixel-accurate spot detection in diverse 2D and 3D images. The improved accuracy offered by Spotiflow enables improved biological insights in...
rdcu.be
June 6, 2025 at 6:58 PM
Spotiflow, our deep learning based spot detection method for microscopy, is now published in @natmethods.nature.com!
Since the pre-print, we have added many features, notably native 3D detection!
@maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social
Paper: rdcu.be/epIB7
(1/N)
Since the pre-print, we have added many features, notably native 3D detection!
@maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social
Paper: rdcu.be/epIB7
(1/N)
Reposted by Lukas Frank
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company
YouTube video by Amanpour and Company
youtu.be
May 24, 2025 at 1:13 AM
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Reposted by Lukas Frank
🚨 Preprint alert 🚨
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Ab-trapping - a peripheral staining artifact in antibody-based microscopy and genomics
Antibodies (Ab) are essential for detecting specific epitopes in microscopy and genomics, but can produce artifacts leading to erroneous interpretations. Here, we characterize a novel artifact, Ab-tra...
doi.org
April 14, 2025 at 8:08 PM
🚨 Preprint alert 🚨
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Reposted by Lukas Frank
From enhancer hijacking to ecDNA and onco-condensates – we review how changes in nuclear architecture drive oncogenic gene expression by disrupting enhancer–promoter communication. doi.org/10.1002/ijc..... Kudos to Isabelle Seufert, @claire-vrgs.bsky.social and Sina Wille 👏
April 12, 2025 at 8:38 PM
From enhancer hijacking to ecDNA and onco-condensates – we review how changes in nuclear architecture drive oncogenic gene expression by disrupting enhancer–promoter communication. doi.org/10.1002/ijc..... Kudos to Isabelle Seufert, @claire-vrgs.bsky.social and Sina Wille 👏
Reposted by Lukas Frank
Finally in its nice looking journal style 🤩🥳🍾
Check out our paper about DNA methylation, engram maturation and systems consolidation.
You can find a 🧵 on my previous link
bsky.app/profile/jani...
Thanks to all people involved and the journal for awarding it "Priority Communication"
Check out our paper about DNA methylation, engram maturation and systems consolidation.
You can find a 🧵 on my previous link
bsky.app/profile/jani...
Thanks to all people involved and the journal for awarding it "Priority Communication"
April 5, 2025 at 5:51 AM
Finally in its nice looking journal style 🤩🥳🍾
Check out our paper about DNA methylation, engram maturation and systems consolidation.
You can find a 🧵 on my previous link
bsky.app/profile/jani...
Thanks to all people involved and the journal for awarding it "Priority Communication"
Check out our paper about DNA methylation, engram maturation and systems consolidation.
You can find a 🧵 on my previous link
bsky.app/profile/jani...
Thanks to all people involved and the journal for awarding it "Priority Communication"
Reposted by Lukas Frank
🧬🌟We're excited to add an Extrachromosomal Circular DNA conference to our 2025 calendar!🧬🌟
Chairs Birgitte Regenberg (Univ. of Copenhagen) & Zhao Zhang (Duke Univ.) are bringing a fantastic line up of speakers together in Mexico this year. More details➡️https://bit.ly/4az0PbV #ecDNA25 #eccDNA #ecDNA
Chairs Birgitte Regenberg (Univ. of Copenhagen) & Zhao Zhang (Duke Univ.) are bringing a fantastic line up of speakers together in Mexico this year. More details➡️https://bit.ly/4az0PbV #ecDNA25 #eccDNA #ecDNA
January 23, 2025 at 4:39 PM