Lucas Nivon
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lucasnivon.bsky.social
Lucas Nivon
@lucasnivon.bsky.social
400 followers 1K following 160 posts
CEO and co-founder at Cyrus Bio. Co-founder OpenFold AI bio consortium. Computational protein/biologic discovery. Rare disease, auto-immune, anti-viral, vax. PhD Harvard Biophys, Postdoc Bakerlab at UW. #Urbanism, #bikes, #democracy, #proteinai
Posts Replies Media Videos
Reposted by Lucas Nivon
pushtheneedle.bsky.social
This is great and also illustrates how frivolous and completely damaging design review is for housing in our city
qagggy.bsky.social Qagggy! @qagggy.bsky.social · Sep 30
The project at 118 W. Mercer Street is back! This is the project on the old Tup Tim Thai site that was brutally murdered by Design Review and left a smoldering ruin in the heart of Uptown.
September 30, 2025 at 5:02 PM
lucasnivon.bsky.social
Explaining #seattle housing politics to a New Yorker is hilarious. nimby position is new buildings only downtown. The far left most yimby position is brownstone height buildings near commercial centers. The notion of brownstone height everywhere or some taller buildings is outside polite discourse.
September 30, 2025 at 5:16 AM
Reposted by Lucas Nivon
synbiogaolab.bsky.social
Having often dealt with the frustration of binder-limited projects, we sought a more accessible source for nanobodies than yeast display or llama. Here we introduce Germinal, computationally designing antibody-like binders with such a hit rate that only tens need to be screened for each target.
September 24, 2025 at 4:32 PM
Reposted by Lucas Nivon
amunts.bsky.social
Speak up to prevent a major loss for the field. CASP, which helped shaping structural biology including AlphaFold is on the verge of shutting down. NIH funding has lapsed, UC Davis support ends and the core team is being let go. Painfully shortsighted.
Exclusive: Famed protein structure competition nears end as NIH grant money runs out
Agency silent on funding renewal for contest that inspired creation of AIs that predicted how proteins would fold
www.science.org
July 4, 2025 at 12:07 PM
Reposted by Lucas Nivon
brenttoderian.bsky.social
“Someone with a 1-hr car commute needs to earn 40% more to be as happy as someone with a short walk to work. On the other hand, if someone shifts from a long commute to a walk, their happiness increases as much as if they’d fallen in love.” #CityMakingMath

50 reasons to want more walkable cities.
50 Reasons Why Everyone Should Want More Walkable Streets
From making you live longer to making cities more resilient: If you want a reason to make your city more walkable, it's in here.
www.fastcompany.com
June 26, 2025 at 2:12 PM
Reposted by Lucas Nivon
mollyknight.bsky.social
Job Garcia’s kidnapping by the Trump administration is the top story on the LA Times website right now.

www.latimes.com/california/s...
A 37-year-old U.S. citizen who was tackled to the ground and arrested after filming federal agents at Home Depot on Thursday said he was held for more than an hour near Dodger Stadium, where agents boasted about how many immigrants they arrested. "How many bodies did you guys grab today?" he said one agent asked. "Oh, we grabbed 31," the other replied. "That was a good day today," the first agent responded. The two high-fived, as Job Garcia sat on the asphalt under the sun, he said. Garcia was released on Friday from a downtown federal detention center. No apparent criminal charges have yet to be filed. He is one of several U.S citizens arrested during enforcement operations in recent days. Department of Homeland Security officias sav some trave ilegaly 11:04 C •ll 5G+ 824) latimes.com "You wanted it, you got it," the man yelled. An agent handcuffed him so hard "that there was no circulation running to my fingers," Garcia said. Pinned down, Garcia had difficulty breathing. "That moment, I thought I could probably die here," he said. The agent put Garcia's phone back in his pocket. The recording kept running. As Garcia was put into a vehicle, his video captured an agent twice saying: "I've got one back here." "You got one what?" Garcia shot back. "You got one what?" He said an agent told him in broken Spanish to "wait here,' though it could not be heard on the video. - 11:04 € • 5G+ 824) latimes.com "I f- speak English, you f- dumbass," he clearly shouts back. No agent asked if he was an American citizen, he said. Nobody asked for identification. "They assumed that I was undocumented," he said later in an interview. The video ends after about four minutes, while he is waiting in the van. CALIFORNIA Raid at a Home Depot in Hollywood shatters an immigrant refuge June 20, 2025 Garcia asked an agent to get his wallet from his car, so he could prove he was a U.S. citizen. Another agent retrieved his ID, but he remained handcuffed. They were so tight, his hands hegan to swell. Garcia asked an agent to get his wallet from his car, so he could prove he was a U.S. citizen. Another agent retrieved his ID, but he remained handcuffed. They were so tight, his hands began to swell. The agents switched him to handcuffs that looked like shoelaces. They took off around a corner, stopped to shuffle him into another van and sped off down the 101 Freeway. "I smeared my blood in their seat," he said. And he thought, "They're going to remember me."
June 21, 2025 at 6:08 AM
lucasnivon.bsky.social
One of the hardest things about growing up in #nyc and living elsewhere is the utter lack of Chinese Cuban restaurants #iykyk… Trader Joe’s plantains scratch that itch
June 16, 2025 at 2:34 AM
Reposted by Lucas Nivon
seattleindivisible.bsky.social
Excited to announce that Pramila Jayapal will be our featured speaker at the Rally before the JUNE 14th - Seattle NO KINGS MARCH.

#nokings #DefendDemocracy #FightAuthoritarians #NoFascism
June 10, 2025 at 3:01 AM
Reposted by Lucas Nivon
handle.invalid
#seattle
June 14, 2025 at 7:23 PM
Reposted by Lucas Nivon
drjanicekirsch.bsky.social
THE AMERICAN MEDICAL ASSOCIATION CALLS FOR A SENATE INVESTIGATION INTO RFK, JR.

"The resolution’s sponsor, Dr. Jason Goldman, urged his colleagues to support the request for an investigation to ensure the AMA is not “on the wrong side of history.”

chicago.suntimes.com/health/2025/...
Investigate federal vaccine panel's overhaul, AMA urges Senate
Health and Human Services Secretary Robert F. Kennedy Jr., a longtime skeptic of vaccinations, said he ousted the CDC committee to restore "public trust in vaccines."
chicago.suntimes.com
June 13, 2025 at 2:13 AM
Reposted by Lucas Nivon
jonathancohn.bsky.social
"If there were justice in the world, Musk would never be able to repair his reputation, at least not without devoting the bulk of his fortune to easing the misery he’s engendered."

www.nytimes.com/2025/05/30/o...
Opinion | Elon Musk’s Legacy Is Disease, Starvation and Death
www.nytimes.com
May 31, 2025 at 3:32 AM
lucasnivon.bsky.social
Temporary, but a clear win for HB1110 legal approach! Little fanfare is ideal really, when tensions run so high
May 29, 2025 at 3:10 PM
Reposted by Lucas Nivon
chrismurphyct.bsky.social
This guy stole $10 million from the employees of his nursing home to buy himself a luxury yacht and Cartier watches. He PLED GUILTY.

And because his Mom gave Trump $1 million, he just got a pardon.

And this story barely makes the news today. WTF. www.nytimes.com/2025/05/27/u...
Trump Pardoned Tax Cheat After Mother Attended $1 Million Dinner
www.nytimes.com
May 28, 2025 at 12:14 AM
Reposted by Lucas Nivon
cyrilpedia.bsky.social
'(...) we could end up with completely new treatments for some of these conditions (or for subsets of patients therein), but no matter what we're going to learn a tremendous amount about the role of B cells in their etiologies, from several different angles all at once'
@dereklowe.bsky.social
Autoimmune Disease, Transformed?
www.science.org
May 27, 2025 at 4:32 AM
Reposted by Lucas Nivon
cyrusbio.bsky.social
Cyrus's CEO, Lucas Nivon, is the keynote speaker for Nucleate Seattle’s Activator Demo Day! Join us to hear him speak about Life Sciences Commercialization on May 14th at the Allen Institute. #Seattle #Biotech #Innovation lu.ma/18yj2jg3?tk=...
Nucleate Seattle: 2025 Demo Day · Luma
Please join Nucleate Seattle in celebrating our 2025 Activator cohort at our Demo Day! We invite all biotech and bio-entrepreneurial enthusiasts of all stages…
lu.ma
May 13, 2025 at 8:33 PM
Reposted by Lucas Nivon
amunts.bsky.social
The structure of human sweetness: Cell
Sweet receptor bound to two widely used artificial sweeteners: sucralose and aspartame. A single receptor that mediates all our responses to sweet-tasting compounds.
May 8, 2025 at 6:05 PM
Reposted by Lucas Nivon
carlzimmer.com
Nature reports that the National Science Foundation has stopped awarding new grants and allotting funds to existing ones. All of them. @colincarlson.bsky.social says that unless the freeze is lifted, it “is going to destroy people's labs.” 2/10
www.nature.com/articles/d41...
Exclusive: NSF stops awarding new grants and funding existing ones
US science funder also plans to screen grant applications for compliance with ‘agency priorities’.
www.nature.com
May 1, 2025 at 11:50 PM
lucasnivon.bsky.social
Great piece. Often try to explain this to tech people, they train on human data, it is often easily observable. In bio much of data is invisible to us, now we have transcriptomics, spatial bio, etc. Hubble telescope is an example, before that you can’t see so far! We need bio Hubbles
dereklowe.bsky.social Derek Lowe @dereklowe.bsky.social · Apr 21
Thoughts on Demis Hassabis of Google DeepMind saying that AI could cure disease in general in ten years.

Bonus index to my longer posts on AI/computational drug discovery over nearly 20 years!
The End of Disease
www.science.org
April 22, 2025 at 3:04 PM
lucasnivon.bsky.social
So happy @openfold.io is growing! More exciting announcements coming soon about our new all atom model adding ligand and RNA/DNA
April 15, 2025 at 3:06 PM
lucasnivon.bsky.social
Idea for a hit movie: 3 professors have their research funding cut. They bootstrap a startup on services revenue, using the services to create new niche products. No VC funding. It is called… Ghostbusters (that’s the actual plot!) #scisky #startups #vc #bootstrap
April 8, 2025 at 2:58 AM
lucasnivon.bsky.social
Protein binder design workflows for everyone! #ai #biotech
levitate.bio Levitate Bio @levitate.bio · Feb 18
BindCraft is a new AI de novo binder design tool from the Correia lab with 10-100% success rates. It's available today as an easy to use API using our API framework so you can deploy it in your own pipeline today.

Contact us at levitate.bio/contact to get started
www.biorxiv.org/content/10.1...
BindCraft: one-shot design of functional protein binders
Protein–protein interactions (PPIs) are at the core of all key biological processes. However, the complexity of the structural features that determine PPIs makes their design challenging. We present B...
www.biorxiv.org
April 8, 2025 at 2:37 AM
Reposted by Lucas Nivon
chrislhayes.bsky.social
They’re going to keep pushing until something stops them.
April 8, 2025 at 1:50 AM
Reposted by Lucas Nivon
peterhotezmdphd.bsky.social
My first post on BlueSky, I could not access the same handle as my X (someone hacked into that one):

So it's @peterhotez for X and @peterhotezmdphd for BlueSky

I'm a pediatric-vaccine scientist based in Houston TX at our Texas Medical Center
April 5, 2025 at 7:12 PM
Reposted by Lucas Nivon
carlzimmer.com
“Kennedy’s team requested that Marks turn over data on cases of brain swelling and deaths caused by the measles vaccine—data that Marks said doesn’t exist because there have been no such confirmed cases in the U.S.” www.wsj.com/health/healt...
Exclusive | Ousted Vaccine Chief Says RFK Jr.’s Team Sought Data to Justify Anti-Science Stance
Dr. Peter Marks says the new health secretary’s team wants to show vaccines aren’t safe while promoting dangerous and unproven treatments.
www.wsj.com
April 4, 2025 at 7:42 PM
lucasnivon.bsky.social
Thinking about printers and #biotech #ai
Why are printers so lame?
Because the interface from software to real world is complex. Ink on paper is relatively simple but still not robust.
April 4, 2025 at 5:30 AM