Lorenzo Pasquali
@lorenzpasquali.bsky.social
Research professor @UPFBarcelona genetics and regulatory genomics, islet and chromatin but also father, travelling, campervan, sailing, handbike and kayaking.
Reposted by Lorenzo Pasquali
Many exciting opportunities for a PhD in Life Sciences in CRG, Barcelona. If you are interested in Genomics of Diabetes check out the offer for a fully funded fellowship in our lab - we will consider candidates with experimental or computational backgrounds.
Please spread the word!
Please spread the word!
Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you.
More info: www.crg.eu/en/content/t...
More info: www.crg.eu/en/content/t...
October 23, 2025 at 9:09 AM
Many exciting opportunities for a PhD in Life Sciences in CRG, Barcelona. If you are interested in Genomics of Diabetes check out the offer for a fully funded fellowship in our lab - we will consider candidates with experimental or computational backgrounds.
Please spread the word!
Please spread the word!
Reposted by Lorenzo Pasquali
We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...).
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
November 6, 2025 at 6:37 PM
We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...).
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details 👇
Reposted by Lorenzo Pasquali
#HelmholtzMunich Receives Funding from la Caixa Foundation to Develop Regenerative #Diabetes Therapy
t1p.de/ew4iy
Focus: Developing stress-resistant beta cells
Goal: Overcome immune rejection & enhance #CellReplacementTherapy
@heikolickert.bsky.social @lorenzpasquali.bsky.social
t1p.de/ew4iy
Focus: Developing stress-resistant beta cells
Goal: Overcome immune rejection & enhance #CellReplacementTherapy
@heikolickert.bsky.social @lorenzpasquali.bsky.social
February 21, 2025 at 8:05 AM
#HelmholtzMunich Receives Funding from la Caixa Foundation to Develop Regenerative #Diabetes Therapy
t1p.de/ew4iy
Focus: Developing stress-resistant beta cells
Goal: Overcome immune rejection & enhance #CellReplacementTherapy
@heikolickert.bsky.social @lorenzpasquali.bsky.social
t1p.de/ew4iy
Focus: Developing stress-resistant beta cells
Goal: Overcome immune rejection & enhance #CellReplacementTherapy
@heikolickert.bsky.social @lorenzpasquali.bsky.social
Reposted by Lorenzo Pasquali
Still time to apply!
Applications from US welcome – four years can feel longer or shorter depending on where you are 😉
Applications from US welcome – four years can feel longer or shorter depending on where you are 😉
📣 Hiring, please forward widely!!
Two postdoc openings to work on genomics of diabetes
1. Computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling
DM if interested
@crg.eu
shorturl.at/O3wMi
shorturl.at/ieyZy
Two postdoc openings to work on genomics of diabetes
1. Computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling
DM if interested
@crg.eu
shorturl.at/O3wMi
shorturl.at/ieyZy
Postdoctoral scientist, gene regulatory mechanisms and diabetes | CRG Online Recruitment Portal
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
shorturl.at
February 2, 2025 at 8:18 PM
Still time to apply!
Applications from US welcome – four years can feel longer or shorter depending on where you are 😉
Applications from US welcome – four years can feel longer or shorter depending on where you are 😉
Reposted by Lorenzo Pasquali
📣 Hiring, please forward widely!!
Two postdoc openings to work on genomics of diabetes
1. Computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling
DM if interested
@crg.eu
shorturl.at/O3wMi
shorturl.at/ieyZy
Two postdoc openings to work on genomics of diabetes
1. Computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling
DM if interested
@crg.eu
shorturl.at/O3wMi
shorturl.at/ieyZy
Postdoctoral scientist, gene regulatory mechanisms and diabetes | CRG Online Recruitment Portal
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
shorturl.at
December 31, 2024 at 11:20 AM
📣 Hiring, please forward widely!!
Two postdoc openings to work on genomics of diabetes
1. Computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling
DM if interested
@crg.eu
shorturl.at/O3wMi
shorturl.at/ieyZy
Two postdoc openings to work on genomics of diabetes
1. Computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling
DM if interested
@crg.eu
shorturl.at/O3wMi
shorturl.at/ieyZy
Reposted by Lorenzo Pasquali
🚨🚨🚨
If you're a bioinformatician who loves:
🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling
Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com
Please RT! 🙏
If you're a bioinformatician who loves:
🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling
Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com
Please RT! 🙏
December 23, 2024 at 3:54 PM
🚨🚨🚨
If you're a bioinformatician who loves:
🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling
Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com
Please RT! 🙏
If you're a bioinformatician who loves:
🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling
Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com
Please RT! 🙏
Reposted by Lorenzo Pasquali
Exciting study by Amanda Andersson Rolf et al: In vitro expansion of a human fetal #pancreas #stemcell that generates all three pancreatic cell lineages”. www.cell.com/cell/fulltex...
New #organoid protocol allows the seemingly indefinite expansion of human fetal pancreatic Lgr5+ stem cell 1/
New #organoid protocol allows the seemingly indefinite expansion of human fetal pancreatic Lgr5+ stem cell 1/
Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages
Identification of an LGR5 as a marker for a tripotent stem/progenitor cell of the
human fetal pancreas. Organoids derived from single LGR5+ cells are capable of long-term
expansion in vitro and genera...
www.cell.com
December 3, 2024 at 10:52 AM
Exciting study by Amanda Andersson Rolf et al: In vitro expansion of a human fetal #pancreas #stemcell that generates all three pancreatic cell lineages”. www.cell.com/cell/fulltex...
New #organoid protocol allows the seemingly indefinite expansion of human fetal pancreatic Lgr5+ stem cell 1/
New #organoid protocol allows the seemingly indefinite expansion of human fetal pancreatic Lgr5+ stem cell 1/
Reposted by Lorenzo Pasquali
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism
The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.
doi.org
November 25, 2024 at 11:16 AM
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
Reposted by Lorenzo Pasquali
1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces.
biorxiv.org/content/10.1101/2024.11.06.622266v1
biorxiv.org/content/10.1101/2024.11.06.622266v1
November 20, 2024 at 2:29 PM
1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces.
biorxiv.org/content/10.1101/2024.11.06.622266v1
biorxiv.org/content/10.1101/2024.11.06.622266v1