The other one on how the misregulation of a key meiotic factor might affect genome stability tinyurl.com/pjxrvur9

Six more years—plus a lot of blood, sweat, and tears—later, we are thrilled to finally share it: a cytological framework of female meiosis in Arabidopsis!

www.biorxiv.org/content/10.1...

My lab @bokuvienna.bsky.social has an opening for a PhD on Synthetic Single Carbon Assimilation in Yeast.
Find details here www.circularbioengineering.at/jobsprogram2 - PhD 2.1 if you consider joining us within the Cluster of Excellence Circular Bioengineering

Thanks for your message. We don't know enough about biocide selection in C. auris and how this affects its genetics and biology, so hard to tell.

we observe that these variants show little changes in biochemical and ultrastructural features of the cell wall, and that the moderate fitness trade-offs ultimately do not impinge on the pathogenicity potential of C. auris (in contrast to what has been reported for Candida albicans). 4/4

we show that these variants produce cross-resistance to other echinocandin drugs but moderate collateral sensitivity to other antifungals and cell wall stress (fitness trade-offs) 3/n

we show that caspofungin-resistant isolates harbour SNPs in the expected target gene FKS1 (FKS1-S639P and FKS1-S639Y variants) 2/n

In this manuscript we show that a caspofungin-sensitive C. auris clade II isolate can develop resistance against caspofungin during in vitro evolution under drug pressure (similar approaches were previously unsuccessful) 1/n