Lorenza Mottes
@lorenzamottes.bsky.social
Studying chromatin replication in stem cells | PhD student in the Schneider Lab, Helmholtz Munich @robertife.bsky.social @epihmgu.bsky.social
Reposted by Lorenza Mottes
Next week GIIN webinar will feature @fmattiroli.bsky.social and Marco Tigano. Join us on Tuesday, October 7th at 5 PM Rome / 11 AM NYC via zoom: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
Register here to become part of our community: docs.google.com/forms/d/e/1F...
September 30, 2025 at 5:24 PM
Next week GIIN webinar will feature @fmattiroli.bsky.social and Marco Tigano. Join us on Tuesday, October 7th at 5 PM Rome / 11 AM NYC via zoom: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
Register here to become part of our community: docs.google.com/forms/d/e/1F...
Reposted by Lorenza Mottes
#Jobalert 🚨: Please RT !
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...
September 22, 2025 at 2:22 PM
#Jobalert 🚨: Please RT !
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...
Reposted by Lorenza Mottes
Our next #DevPres webinar focusses on gene regulation with talks from 2025 Development PI fellows Anzy Miller @anzymiller.bsky.social and Marlies Oomen @marliesoomen.bsky.social, chaired by James Gahan @jgahan.bsky.social.
📆 27 August, 15:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
📆 27 August, 15:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
August 14, 2025 at 2:09 PM
Our next #DevPres webinar focusses on gene regulation with talks from 2025 Development PI fellows Anzy Miller @anzymiller.bsky.social and Marlies Oomen @marliesoomen.bsky.social, chaired by James Gahan @jgahan.bsky.social.
📆 27 August, 15:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
📆 27 August, 15:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
Reposted by Lorenza Mottes
Very happy that this (last?) piece of my PhD time in the Dekker lab is now out in Genome Research! genome.cshlp.org/content/earl... @jobdekker.bsky.social @pablonavarrolab.bsky.social @genomeresearch.bsky.social
Mitotic chromosomes harbor cell type– and species-specific structural features within a universal loop array conformation
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
genome.cshlp.org
July 22, 2025 at 4:17 PM
Very happy that this (last?) piece of my PhD time in the Dekker lab is now out in Genome Research! genome.cshlp.org/content/earl... @jobdekker.bsky.social @pablonavarrolab.bsky.social @genomeresearch.bsky.social
Reposted by Lorenza Mottes
Linker histone expression is uniquely controlled by a specific pathway, which can be manipulated to increase TOP2i sensitivity! Proud to share first authorship on our story now out in @cp-molcell.bsky.social. www.cell.com/molecular-ce...
CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance
Ingham et al. identify a dedicated H1 linker histone biogenesis pathway in human cells,
driven by the protein CRAMP1 that functions as an H1 transcription factor. They demonstrate
that defective CRAMP...
www.cell.com
June 19, 2025 at 6:39 AM
Linker histone expression is uniquely controlled by a specific pathway, which can be manipulated to increase TOP2i sensitivity! Proud to share first authorship on our story now out in @cp-molcell.bsky.social. www.cell.com/molecular-ce...
Reposted by Lorenza Mottes
Histone modifications in development
Read this 'Development at a Glance' article by Yu-Hao Liu and @robertife.bsky.social, summarising the role of selected histone modifications during development.
journals.biologists.com/dev/article/...
Read this 'Development at a Glance' article by Yu-Hao Liu and @robertife.bsky.social, summarising the role of selected histone modifications during development.
journals.biologists.com/dev/article/...
June 18, 2025 at 8:51 AM
Histone modifications in development
Read this 'Development at a Glance' article by Yu-Hao Liu and @robertife.bsky.social, summarising the role of selected histone modifications during development.
journals.biologists.com/dev/article/...
Read this 'Development at a Glance' article by Yu-Hao Liu and @robertife.bsky.social, summarising the role of selected histone modifications during development.
journals.biologists.com/dev/article/...
Reposted by Lorenza Mottes
🧪 David Skerrett-Byrne speaks at #PintOfScience today – and just published a new study!
🐨 Sperm from 12 species, 135 key proteins.
💡 A shared fertility blueprint – with impact for infertility, IVF & contraception.
📄Full paper: t1p.de/cnc9o
#ReproductiveHealth #Pint25
@davidskerrettb.bsky.social
🐨 Sperm from 12 species, 135 key proteins.
💡 A shared fertility blueprint – with impact for infertility, IVF & contraception.
📄Full paper: t1p.de/cnc9o
#ReproductiveHealth #Pint25
@davidskerrettb.bsky.social
Towards a kingdom of reproductive life - the core sperm proteome
In brief Sperm function is essential for fertility across humans, agriculture and wildlife, yet comparative studies remain limited. This study integrates multi-species proteomic data to identify a cor...
t1p.de
May 19, 2025 at 9:09 AM
🧪 David Skerrett-Byrne speaks at #PintOfScience today – and just published a new study!
🐨 Sperm from 12 species, 135 key proteins.
💡 A shared fertility blueprint – with impact for infertility, IVF & contraception.
📄Full paper: t1p.de/cnc9o
#ReproductiveHealth #Pint25
@davidskerrettb.bsky.social
🐨 Sperm from 12 species, 135 key proteins.
💡 A shared fertility blueprint – with impact for infertility, IVF & contraception.
📄Full paper: t1p.de/cnc9o
#ReproductiveHealth #Pint25
@davidskerrettb.bsky.social
Reposted by Lorenza Mottes
Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....
Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes
Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...
doi.org
May 4, 2025 at 7:39 AM
Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....
Reposted by Lorenza Mottes
How does the genome find its place in the 3D space of the nucleus after fertilization?
Out now @cellcellpress.bsky.social:
cell.com/cell/fulltext/…
👇 A thread 👇
Out now @cellcellpress.bsky.social:
cell.com/cell/fulltext/…
👇 A thread 👇
April 23, 2025 at 6:04 PM
How does the genome find its place in the 3D space of the nucleus after fertilization?
Out now @cellcellpress.bsky.social:
cell.com/cell/fulltext/…
👇 A thread 👇
Out now @cellcellpress.bsky.social:
cell.com/cell/fulltext/…
👇 A thread 👇
Reposted by Lorenza Mottes
we've put a Review together 👇
Just came out at www.nature.com/articles/s41...
hoping it is useful for those in the field but also for those not in the field who would like an overview on chromatin/epigenetics/replication/nuclear organisation in early embryos
Enjoy :) - feedback welcome
Just came out at www.nature.com/articles/s41...
hoping it is useful for those in the field but also for those not in the field who would like an overview on chromatin/epigenetics/replication/nuclear organisation in early embryos
Enjoy :) - feedback welcome
April 10, 2025 at 4:32 PM
we've put a Review together 👇
Just came out at www.nature.com/articles/s41...
hoping it is useful for those in the field but also for those not in the field who would like an overview on chromatin/epigenetics/replication/nuclear organisation in early embryos
Enjoy :) - feedback welcome
Just came out at www.nature.com/articles/s41...
hoping it is useful for those in the field but also for those not in the field who would like an overview on chromatin/epigenetics/replication/nuclear organisation in early embryos
Enjoy :) - feedback welcome
Reposted by Lorenza Mottes
🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome
April 6, 2025 at 9:45 AM
🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome
Reposted by Lorenza Mottes
🤩Save the date:
Marieke Oudelaar will speak on Molecular Drivers of 3D Genome Folding and Their Function in Gene Regulation💬
We look forward to meeting @mariekeoudelaar.bsky.social😆
Join us on April 8 at 1:30 pm🤗
➡️Lynen Lecture Hall
@mpi-nat.bsky.social
Marieke Oudelaar will speak on Molecular Drivers of 3D Genome Folding and Their Function in Gene Regulation💬
We look forward to meeting @mariekeoudelaar.bsky.social😆
Join us on April 8 at 1:30 pm🤗
➡️Lynen Lecture Hall
@mpi-nat.bsky.social
March 27, 2025 at 11:00 AM
🤩Save the date:
Marieke Oudelaar will speak on Molecular Drivers of 3D Genome Folding and Their Function in Gene Regulation💬
We look forward to meeting @mariekeoudelaar.bsky.social😆
Join us on April 8 at 1:30 pm🤗
➡️Lynen Lecture Hall
@mpi-nat.bsky.social
Marieke Oudelaar will speak on Molecular Drivers of 3D Genome Folding and Their Function in Gene Regulation💬
We look forward to meeting @mariekeoudelaar.bsky.social😆
Join us on April 8 at 1:30 pm🤗
➡️Lynen Lecture Hall
@mpi-nat.bsky.social
Reposted by Lorenza Mottes
🌟 SAVE THE DATE: Talent Forum 2025!
🗓️ November 18–19
📍 @www.helmholtz-munich.de, Germany
Showcase your research and network with global talents in #Epigenetics & Nucleic Acids Research!
Apply by July 31 for a speaker spot —travel & accommodation covered.
🔜 Website coming soon!
🗓️ November 18–19
📍 @www.helmholtz-munich.de, Germany
Showcase your research and network with global talents in #Epigenetics & Nucleic Acids Research!
Apply by July 31 for a speaker spot —travel & accommodation covered.
🔜 Website coming soon!
March 25, 2025 at 11:02 AM
🌟 SAVE THE DATE: Talent Forum 2025!
🗓️ November 18–19
📍 @www.helmholtz-munich.de, Germany
Showcase your research and network with global talents in #Epigenetics & Nucleic Acids Research!
Apply by July 31 for a speaker spot —travel & accommodation covered.
🔜 Website coming soon!
🗓️ November 18–19
📍 @www.helmholtz-munich.de, Germany
Showcase your research and network with global talents in #Epigenetics & Nucleic Acids Research!
Apply by July 31 for a speaker spot —travel & accommodation covered.
🔜 Website coming soon!
Reposted by Lorenza Mottes
Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less'
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
February 21, 2025 at 3:50 PM
Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less'
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
Reposted by Lorenza Mottes
I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery.
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery
Abstract. Progressing transcription and replication machineries profoundly impact their underlying chromatin template. Consequently, transcription-replicat
academic.oup.com
February 20, 2025 at 1:38 PM
I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery.
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
academic.oup.com/nar/article/...
#TRC #r-loop #chromatin
More below 👇
Reposted by Lorenza Mottes
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability
Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.
tinyurl.com
February 19, 2025 at 7:35 PM
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Reposted by Lorenza Mottes
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 12, 2025 at 6:28 AM
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Lorenza Mottes
Happy to share this concise review and outlook for single-cell sequencing methods to unravel cell biology of the nucleus! Big shoutout to my friend and former colleague Peter Zeller for sharing the work!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Shining a light on cell biology of the nucleus with single-cell sequencing
From the preservation of genomic integrity to the regulation of RNA translation, nearly all cellular processes are regulated in a cell context-depende…
www.sciencedirect.com
February 4, 2025 at 7:27 AM
Happy to share this concise review and outlook for single-cell sequencing methods to unravel cell biology of the nucleus! Big shoutout to my friend and former colleague Peter Zeller for sharing the work!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Lorenza Mottes
This Friday! Job Dekker, PhD presents the Monthly Seminar on Physical Genomics: Mechanisms of Chromosome Folding
January 31, 2025 - Live on Zoom @ 12pm CT - Registration is free at tinyurl.com/5n6ep25m
#chromatin #genomics #northwestern #research #dna #umass #biophysics #epigenetics #biology
January 31, 2025 - Live on Zoom @ 12pm CT - Registration is free at tinyurl.com/5n6ep25m
#chromatin #genomics #northwestern #research #dna #umass #biophysics #epigenetics #biology
January 28, 2025 at 5:16 PM
This Friday! Job Dekker, PhD presents the Monthly Seminar on Physical Genomics: Mechanisms of Chromosome Folding
January 31, 2025 - Live on Zoom @ 12pm CT - Registration is free at tinyurl.com/5n6ep25m
#chromatin #genomics #northwestern #research #dna #umass #biophysics #epigenetics #biology
January 31, 2025 - Live on Zoom @ 12pm CT - Registration is free at tinyurl.com/5n6ep25m
#chromatin #genomics #northwestern #research #dna #umass #biophysics #epigenetics #biology
Reposted by Lorenza Mottes
We have 7 projects available for undergrad & master students interested in #AI, #chromatin and #epigenetics.
🧬The Chromatin Dynamics and Epigenetics Lab, led by
@robertife.bsky.social, will host an intern during this summer.
🤩Do you want to be her/him?
👉 www.helmholtz-munich.de/en/epigeneti...
🧬The Chromatin Dynamics and Epigenetics Lab, led by
@robertife.bsky.social, will host an intern during this summer.
🤩Do you want to be her/him?
👉 www.helmholtz-munich.de/en/epigeneti...
January 27, 2025 at 12:28 PM
We have 7 projects available for undergrad & master students interested in #AI, #chromatin and #epigenetics.
🧬The Chromatin Dynamics and Epigenetics Lab, led by
@robertife.bsky.social, will host an intern during this summer.
🤩Do you want to be her/him?
👉 www.helmholtz-munich.de/en/epigeneti...
🧬The Chromatin Dynamics and Epigenetics Lab, led by
@robertife.bsky.social, will host an intern during this summer.
🤩Do you want to be her/him?
👉 www.helmholtz-munich.de/en/epigeneti...
Reposted by Lorenza Mottes
I am thrilled to share that our latest pre-print from the @evahoermanseder.bsky.social lab 🐸🧬, is now online! Check it out here:
www.biorxiv.org/content/10.1...
Highlights and key findings from our study in the thread below 👇
www.biorxiv.org/content/10.1...
Highlights and key findings from our study in the thread below 👇
Digital Reprogramming Decodes Epigenetic Barriers of Cell Fate Changes
Fates of differentiated cells in our body can be induced to change by nuclear reprogramming. In this way, cells valuable for therapeutic purposes and disease modeling can be produced. However, the eff...
www.biorxiv.org
January 26, 2025 at 12:10 PM
I am thrilled to share that our latest pre-print from the @evahoermanseder.bsky.social lab 🐸🧬, is now online! Check it out here:
www.biorxiv.org/content/10.1...
Highlights and key findings from our study in the thread below 👇
www.biorxiv.org/content/10.1...
Highlights and key findings from our study in the thread below 👇
Reposted by Lorenza Mottes
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development
In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...
doi.org
January 22, 2025 at 1:56 PM
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
Reposted by Lorenza Mottes
Please RS/RT. #GordonConference "Histone and DNA Modifications" Program is now online 🍾 #epigenetics #chromatin #histones 20.-25. July. Il Ciocco 🇮🇹
Register now: ➡️ shorturl.at/AtAjz
Exciting speaker lineup, many slots for talks selected from abstracts
Register now: ➡️ shorturl.at/AtAjz
Exciting speaker lineup, many slots for talks selected from abstracts
January 23, 2025 at 1:47 PM
Please RS/RT. #GordonConference "Histone and DNA Modifications" Program is now online 🍾 #epigenetics #chromatin #histones 20.-25. July. Il Ciocco 🇮🇹
Register now: ➡️ shorturl.at/AtAjz
Exciting speaker lineup, many slots for talks selected from abstracts
Register now: ➡️ shorturl.at/AtAjz
Exciting speaker lineup, many slots for talks selected from abstracts
Reposted by Lorenza Mottes
Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex...
A short thread to highlight some of our findings 🧵
A short thread to highlight some of our findings 🧵
January 20, 2025 at 8:29 PM
Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex...
A short thread to highlight some of our findings 🧵
A short thread to highlight some of our findings 🧵