Logan Thrasher Collins
@logantcollins.bsky.social
Synthetic biologist, futurist, author. Biomedical engineering PhD candidate at WashU. Budding serial biotech entrepreneur. You can learn more about me on my website: https://logancollinsblog.com/
Highly informative paper! Various small molecules were linked to lipid nanoparticles (LNPs), improving the amounts of LNPs that crossed the blood-brain-barrier (BBB) in mice and in cell culture models of the BBB. Link: pubs.acs.org/doi/10.1021/...
September 20, 2025 at 5:13 PM
Highly informative paper! Various small molecules were linked to lipid nanoparticles (LNPs), improving the amounts of LNPs that crossed the blood-brain-barrier (BBB) in mice and in cell culture models of the BBB. Link: pubs.acs.org/doi/10.1021/...
Liu et al. present a remarkably simple yet clever method of mitigating the effects of head-mounted microscopes on mouse behavior: they tethered a helium balloon to the microscope device to counter its weight! A fun and useful engineering solution!
Link to article: www.nature.com/articles/s41...
Link to article: www.nature.com/articles/s41...
September 10, 2025 at 10:32 PM
Liu et al. present a remarkably simple yet clever method of mitigating the effects of head-mounted microscopes on mouse behavior: they tethered a helium balloon to the microscope device to counter its weight! A fun and useful engineering solution!
Link to article: www.nature.com/articles/s41...
Link to article: www.nature.com/articles/s41...
Some of my favorite quotes from the article:
August 13, 2025 at 12:09 AM
Some of my favorite quotes from the article:
A wonderfully futuristic paper by Sheng et al.! Link: www.nature.com/articles/s41... "Brain implantation of soft bioelectronics via embryonic development"
July 25, 2025 at 12:48 AM
A wonderfully futuristic paper by Sheng et al.! Link: www.nature.com/articles/s41... "Brain implantation of soft bioelectronics via embryonic development"
Guo et al. developed a transgenic mouse model which can be inducibly deafened for more informative studies of ultrasonic neuromodulation. Link: doi.org/10.1016/j.is...
July 15, 2025 at 1:04 AM
Guo et al. developed a transgenic mouse model which can be inducibly deafened for more informative studies of ultrasonic neuromodulation. Link: doi.org/10.1016/j.is...
I invite you to sit amongst the butterflies
July 14, 2025 at 1:40 AM
I invite you to sit amongst the butterflies
Had a great time presenting one of my PhD research projects at the International Adenovirus Meeting in Cardiff, Wales! "Covalently linked adenovirus-AAV complexes as a novel platform technology for gene therapy". (Cloth poster ended up a bit ruffled, but still turned out well).
July 13, 2025 at 9:10 PM
Had a great time presenting one of my PhD research projects at the International Adenovirus Meeting in Cardiff, Wales! "Covalently linked adenovirus-AAV complexes as a novel platform technology for gene therapy". (Cloth poster ended up a bit ruffled, but still turned out well).
My image of Mars terraforming made using Midjourney :)
July 11, 2025 at 4:26 PM
My image of Mars terraforming made using Midjourney :)
A cool study by Radford et al. that shows it is possible to pass near-infrared photons through an entire human head! Interestingly, the photons preferentially take trajectories through the cerebrospinal fluid regions due to lower scattering and absorption there.
Link: doi.org/10.1117/1.NP...
Link: doi.org/10.1117/1.NP...
July 6, 2025 at 6:09 PM
A cool study by Radford et al. that shows it is possible to pass near-infrared photons through an entire human head! Interestingly, the photons preferentially take trajectories through the cerebrospinal fluid regions due to lower scattering and absorption there.
Link: doi.org/10.1117/1.NP...
Link: doi.org/10.1117/1.NP...
An exciting therapeutic technology for controllable yet potent CAR T treatment of cancers. Uses an ultrasound-sensitive promoter and a genetic positive feedback loop circuit. My understanding is that this is part of the startup Acoustic Cell Therapy Inc. too! Link to paper: doi.org/10.1016/j.ce...
July 2, 2025 at 2:12 AM
An exciting therapeutic technology for controllable yet potent CAR T treatment of cancers. Uses an ultrasound-sensitive promoter and a genetic positive feedback loop circuit. My understanding is that this is part of the startup Acoustic Cell Therapy Inc. too! Link to paper: doi.org/10.1016/j.ce...
Love this concept - a skyscraper hanging from an asteroid in orbit! While this probably won't be built for awhile, it's still very inspiring and I hope something similar eventually becomes a reality! Link to read more about the proposed design: cloudsao.com/ANALEMMA-TOWER
June 25, 2025 at 12:15 AM
Love this concept - a skyscraper hanging from an asteroid in orbit! While this probably won't be built for awhile, it's still very inspiring and I hope something similar eventually becomes a reality! Link to read more about the proposed design: cloudsao.com/ANALEMMA-TOWER
Had an amazing experience at the AI x Bio conference co-hosted by The Foresight Institute and Vitalia! Made new friends, reunited with old friends, and learned a lot about how AI will transform the future of biological research and longevity technology.
May 30, 2025 at 9:47 PM
Had an amazing experience at the AI x Bio conference co-hosted by The Foresight Institute and Vitalia! Made new friends, reunited with old friends, and learned a lot about how AI will transform the future of biological research and longevity technology.
An excellent review on the mechanically gated PIEZO1 and PIEZO2 ion channels! I highly recommend this paper. Link: www.nature.com/articles/s41... #biochemistry #biophysics #structuralbiology
May 27, 2025 at 11:46 PM
An excellent review on the mechanically gated PIEZO1 and PIEZO2 ion channels! I highly recommend this paper. Link: www.nature.com/articles/s41... #biochemistry #biophysics #structuralbiology
Neuroscience data is getting bigger and will keep getting bigger. We need new ways of properly visualizing it both as researchers and as science communicators. #data #datavisualization #neuroscience
Link: www.thetransmitter.org/connectome/t...
Link: www.thetransmitter.org/connectome/t...
May 14, 2025 at 10:30 PM
Neuroscience data is getting bigger and will keep getting bigger. We need new ways of properly visualizing it both as researchers and as science communicators. #data #datavisualization #neuroscience
Link: www.thetransmitter.org/connectome/t...
Link: www.thetransmitter.org/connectome/t...
Visually stunning paper by Waltz et al. on using cryoET and cryoEM to reconstruct in situ respirasome structures and thus to better understand the mechanisms of cellular respiration. Link: www.science.org/doi/10.1126/... #biology #biochemistry
April 3, 2025 at 11:56 PM
Visually stunning paper by Waltz et al. on using cryoET and cryoEM to reconstruct in situ respirasome structures and thus to better understand the mechanisms of cellular respiration. Link: www.science.org/doi/10.1126/... #biology #biochemistry
My review of The Fall of Hyperion by Dan Simmons!
March 6, 2025 at 2:46 AM
My review of The Fall of Hyperion by Dan Simmons!
My short story "Starseed" has been published by White Cat Publications! It features the idea of deliberately kicking off life on other planets by seeding them with engineered microorganisms, potentially leading to new civilizations in the distant future! whitecatpublications.com/2025/03/01/s...
March 3, 2025 at 2:13 AM
My short story "Starseed" has been published by White Cat Publications! It features the idea of deliberately kicking off life on other planets by seeding them with engineered microorganisms, potentially leading to new civilizations in the distant future! whitecatpublications.com/2025/03/01/s...
"Poetry is only secondarily about words. Primarily, it is about truth."
-- Martin Silenus, one of the seven pilgrims in the novel Hyperion by Dan Simmons.
-- Martin Silenus, one of the seven pilgrims in the novel Hyperion by Dan Simmons.
February 28, 2025 at 3:15 AM
"Poetry is only secondarily about words. Primarily, it is about truth."
-- Martin Silenus, one of the seven pilgrims in the novel Hyperion by Dan Simmons.
-- Martin Silenus, one of the seven pilgrims in the novel Hyperion by Dan Simmons.
My top 10 favorite science fiction novels in *rough* order. In the case of Hyperion, I am counting "Hyperion" and its sequel "The Fall of Hyperion" as one book. Note that I'm not including standalone short stories, though certain ones would rank very highly if they were here.
February 22, 2025 at 1:48 AM
My top 10 favorite science fiction novels in *rough* order. In the case of Hyperion, I am counting "Hyperion" and its sequel "The Fall of Hyperion" as one book. Note that I'm not including standalone short stories, though certain ones would rank very highly if they were here.
Magnificent paper (link: www.sciencedirect.com/science/arti...) on the remarkable ladderlike organization of endoplasmic reticulum in dendrites and how such structures contribute to neuronal computations. #neuroscience #neurobiology #brain #neurons #biology
February 15, 2025 at 3:15 AM
Magnificent paper (link: www.sciencedirect.com/science/arti...) on the remarkable ladderlike organization of endoplasmic reticulum in dendrites and how such structures contribute to neuronal computations. #neuroscience #neurobiology #brain #neurons #biology
Realistic model of the structure of a single synaptic vesicle from: Takamori, S. et al. Molecular Anatomy of a Trafficking Organelle. Cell 127, 831–846 (2006).
February 8, 2025 at 1:22 AM
Realistic model of the structure of a single synaptic vesicle from: Takamori, S. et al. Molecular Anatomy of a Trafficking Organelle. Cell 127, 831–846 (2006).
My drawing of the glucose-alanine cycle, a part of amino acid metabolism. I made this diagram with Affinity Designer. #biochemistry #metabolism
February 2, 2025 at 12:09 AM
My drawing of the glucose-alanine cycle, a part of amino acid metabolism. I made this diagram with Affinity Designer. #biochemistry #metabolism
I love that Microdrop Technologies (www.microdrop.de) has developed tools for dispensing arrays of droplets with volumes as small as 20 picoliters - which is one 50,000th of a microliter! #biotech #nanotech #instrumentation
January 22, 2025 at 2:02 AM
I love that Microdrop Technologies (www.microdrop.de) has developed tools for dispensing arrays of droplets with volumes as small as 20 picoliters - which is one 50,000th of a microliter! #biotech #nanotech #instrumentation
Here's a nice example of SMILES of a bioactive natural product called cephalostatin-1 (which has anti-tumor properties)!
January 17, 2025 at 3:58 AM
Here's a nice example of SMILES of a bioactive natural product called cephalostatin-1 (which has anti-tumor properties)!