#PathSky I usually like to show cases where the morphology makes sense of the molecular, but here’s one where you kind of need the molecular. Axillary mass, 9 month male. Very hyalinized, infiltration of fat, cracking artifact. Strongly CD34-pos. Giant cell fibroblastoma?

#PathSky 79M with a superficial neck mass. Wildly pleomorphic, quite cellular- undifferentiated pleomorphic sarcoma, right? There are basically no mitoses though, the cells have abundant granular-glassy cytoplasm, there is a lot of inflammation, and many bizarre cells have nuclear inclusions.

#PathSky Slowly growing superficial leg mass, 38M. Well-circumscribed, phleboliths, thrombosed vessels, cellular spindle cell areas, cavernous vascular channels. Dx?

Just like Texas rarely sees snow ❄️, every once in a while you will find a primary tumor of the posterior pituitary so keep it in mind during frozen section analysis! Here is a classic example of pituicytoma showing diffuse nuclear positivity for TTF1 #pathsky #neuropath #medsky 🔬 🧠

#PathSky 37M with a large retroperitoneal mass. Big, fatty thing. The outside quite rightly worried about well-differentiated LPS and a lipomatous angiomyolipoma, but MDM2, SMA and melanocytic markers were negative. Some WDL are MDM2-neg/MDM4-pos. Should we do more molecular ? Or something else?

#PathSky 32M with extra-axial, dural-based, frontoparietal mass. Clearly malignant epithelioid cells arranged in cords and nests in a sclerotic background. Looks a lot like a sclerosing epithelioid fibrosarcoma, and it is strongly MUC4-positive. So, we’re done, right?

#pathsky

✨ Happy New Year! We're excited to connect with the pathology community here on Bluesky. 🏷️Tag your pathology friends to let them know we're here!

#Pathology #PathSky #PathologyOutlines

#PathSky Dear Pathologists everywhere: Please, please, please. Do not entirely submit an 11cm skin excision entirely, in 164 blocks. Yours, Whoever it is You Send Your Consults to.

#PathSky 30M, abdominal wall mass. Microcysts, bland round to spindled cells, thick-walled vessels. Positive for desmin, MyoD1, myogenin, and GFAP. Classic findings in EWSR1::PATZ1 sarcoma. Why isn’t this a fusion-positive RMS? Excellent question…https://pubmed.ncbi.nlm.nih.gov/38043789/

Juxtaoral organ of Chievitz that was too good not to share.

Should be (incidentally) found in sections containing muscle/fascia medial to the medial pterygoid muscle, so often seen in larger mandibular or buccal SqCC resections.

#ENTPath #OralPath #PathSky

#PathSky Solid and cystic mass next to the liver in a 50F with no relevant hx or other masses. Once you think of it, extraspinal myxopapillary ependymoma in a rather odd location seems a good fit. Why not, right?