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livzimmermann.bsky.social
@livzimmermann.bsky.social
26 followers 55 following 0 posts
Postdoc @ Chlanda lab, Heidelberg University
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Reposted
helmholtzhzi.bsky.social
Sinkende #Impfquoten verschärfen auch die Antibiotikaresistenz-Krise: Denn virale Infektionen wie #Masern können nicht selten zu bakteriellen Folgeerkrankungen führen - oft behandelt mit #Antibiotika. @ca.theconversation.com berichtet. #AMR theconversation.com/how-falling-...
How falling vaccination rates are fuelling the antibiotic resistance crisis
Measles is a viral infection, so antibiotics don’t treat it directly. But it weakens the immune system, leading to bacterial infections like pneumonia or ear infections, which do require antibiotics.
theconversation.com
July 29, 2025 at 8:03 AM
Reposted
plosbiology.org
How are bacterial transport machineries regulated by external cues? @brochadolab.bsky.social &co identify environmental chemicals that regulate #transporter transcription, identifying the TF Rob as a key modulator of #EffluxPump expression in #Ecoli #AMR @plosbiology.org 🧪 plos.io/46pUM9Q
Left: Compound-promoter interaction network. Fifty-three significant compound-promoter interactions are shown as edges in a Sankey diagram connecting the compounds (left, source nodes) to the promoters (right, target nodes). Edge thickness represents mean Z-scores (n = 8), while node size represents the total number of interactions. Right: Proposed model for the molecular mechanism of caffeine-ciprofloxacin antagonism. Caffeine triggers expression of MicF small RNA in a Rob-dependent manner, which then binds to the 5′-UTR of ompF mRNA to inhibit and decrease OmpF protein levels. This ultimately prevents ciprofloxacin from entering the cell, resulting in caffeine-ciprofloxacin antagonism
July 23, 2025 at 1:43 PM
Reposted
chlandalab.bsky.social
We are happy this work by Sarah Peterl et al. is out in EMBO J! It was an exciting collaborative effort of several groups in the SFB1129 consortium on pathogen replication and spread. Check out the correlated light and scanning EM method to study virus morphology changes during spread!
June 11, 2025 at 11:42 AM
Reposted
embojournal.org
Neutralizing antibodies promote filamentous morphology of #influenza A virus by inhibiting cellular entry and transmission of spherical viral particles
 #RefereedPreprint c/o @reviewcommons.org by Petr Chlanda @chlandalab.bsky.social and coworkers
www.embopress.org/doi/full/10....
June 10, 2025 at 7:33 AM