Shane Liddelow
@liddelowsa.bsky.social
Neuroscientist and glial aficionado at NYU Grossman School of Medicine/NYU Langone Health in NYC. Posts in my individual/personal capacity.
My lab is full of awesome people doing amazing stuff - check them out: www.liddelowlab.com
he/him
My lab is full of awesome people doing amazing stuff - check them out: www.liddelowlab.com
he/him
Reposted by Shane Liddelow
Very happy to have contributed to this new review on Lewy body dementia in @thelancetneuro.bsky.social led by Sonja W. Scholz. We highlight the latest advances in genetics and pathology. @liddelowsa.bsky.social Check it out! www.sciencedirect.com/science/arti...
Advances in the genetics and pathology of Lewy body dementia
Lewy body dementia is a heterogeneous disease that is underdiagnosed and poorly understood. Pathologically, Lewy body dementia is characterised by the…
www.sciencedirect.com
November 13, 2025 at 12:56 AM
Very happy to have contributed to this new review on Lewy body dementia in @thelancetneuro.bsky.social led by Sonja W. Scholz. We highlight the latest advances in genetics and pathology. @liddelowsa.bsky.social Check it out! www.sciencedirect.com/science/arti...
Reposted by Shane Liddelow
In case you were wondering what to do with precisely 150 minutes of your existence @sfn.org #SfN25 #SanDiego. Join our mini-symposium Single-Cell Multiomics in CNS Injury and Recovery. Guaranteed to contain many glial cells and at least a neuron. I am Co-chairing with Naomi Habib
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
November 11, 2025 at 5:14 PM
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
November 10, 2025 at 4:43 PM
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Reposted by Shane Liddelow
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
October 29, 2025 at 2:57 PM
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Reposted by Shane Liddelow
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Spatial dynamics of brain development and neuroinflammation - Nature
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
www.nature.com
November 5, 2025 at 4:03 PM
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Shane Liddelow
Oligodendrocytes support functional development of subcortical premotor neurons and navigation https://www.biorxiv.org/content/10.1101/2025.11.01.686017v1
November 2, 2025 at 10:15 AM
Oligodendrocytes support functional development of subcortical premotor neurons and navigation https://www.biorxiv.org/content/10.1101/2025.11.01.686017v1
We've been doing some amazing stuff outside the astrocyte realm.
Check out our latest Oligo investigation led by @pryprk.bsky.social !
Check out our latest Oligo investigation led by @pryprk.bsky.social !
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
October 24, 2025 at 4:40 PM
We've been doing some amazing stuff outside the astrocyte realm.
Check out our latest Oligo investigation led by @pryprk.bsky.social !
Check out our latest Oligo investigation led by @pryprk.bsky.social !
Reposted by Shane Liddelow
Astrocyte networks are much larger than previously thought, which “flips the way we think about astrocytes and what their networks may mean,” says @liddelowsa.bsky.social.
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/astrocytes/a...
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/astrocytes/a...
September 4, 2025 at 8:50 PM
Astrocyte networks are much larger than previously thought, which “flips the way we think about astrocytes and what their networks may mean,” says @liddelowsa.bsky.social.
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/astrocytes/a...
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/astrocytes/a...
Great story in the @thetransmitter.bsky.social today by
@callimcflurry.bsky.social. It was fun chatting about @melcooperphd.bsky.social's new research on astrocyte networks.
Read the story here: www.thetransmitter.org/astrocytes/a...
Read the preprint here: www.biorxiv.org/content/10.1...
@callimcflurry.bsky.social. It was fun chatting about @melcooperphd.bsky.social's new research on astrocyte networks.
Read the story here: www.thetransmitter.org/astrocytes/a...
Read the preprint here: www.biorxiv.org/content/10.1...
Astrocyte networks span large swaths of brain
The networks are plastic, connect brain regions that aren’t connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows.
www.thetransmitter.org
September 3, 2025 at 1:39 PM
Great story in the @thetransmitter.bsky.social today by
@callimcflurry.bsky.social. It was fun chatting about @melcooperphd.bsky.social's new research on astrocyte networks.
Read the story here: www.thetransmitter.org/astrocytes/a...
Read the preprint here: www.biorxiv.org/content/10.1...
@callimcflurry.bsky.social. It was fun chatting about @melcooperphd.bsky.social's new research on astrocyte networks.
Read the story here: www.thetransmitter.org/astrocytes/a...
Read the preprint here: www.biorxiv.org/content/10.1...
A fantastic time with an excellent group of trainees at the @neurochemistry.org Advanced School.
Let the conference begin!
Let the conference begin!
August 18, 2025 at 2:28 AM
A fantastic time with an excellent group of trainees at the @neurochemistry.org Advanced School.
Let the conference begin!
Let the conference begin!
are you a PD in the glia (or neuroscience) space? Do you want to come to NYC and give a lecture and meet some amazing faculty here at @nyumedpostdocs.bsky.social?
LAST WEEK TO APPLY to be a SPiNES speaker for our next season.
Details and apply here: med.nyu.edu/departments-...
COME AND WOW US!
LAST WEEK TO APPLY to be a SPiNES speaker for our next season.
Details and apply here: med.nyu.edu/departments-...
COME AND WOW US!
a black and white photo of a crowd of people standing and sitting in chairs .
ALT: a black and white photo of a crowd of people standing and sitting in chairs .
media.tenor.com
August 15, 2025 at 7:57 PM
are you a PD in the glia (or neuroscience) space? Do you want to come to NYC and give a lecture and meet some amazing faculty here at @nyumedpostdocs.bsky.social?
LAST WEEK TO APPLY to be a SPiNES speaker for our next season.
Details and apply here: med.nyu.edu/departments-...
COME AND WOW US!
LAST WEEK TO APPLY to be a SPiNES speaker for our next season.
Details and apply here: med.nyu.edu/departments-...
COME AND WOW US!
The American Society for Neurochemistry (ASN) and the International Society for Neurochemistry (ISN) are hosting a discussion on autism, with clinical, research, family, & pharma perspectives.
August 17, 2025
2-4 PM
Hunter College, West Room 714
FREE
Registration recommended: lnkd.in/dJY7hp-b
August 17, 2025
2-4 PM
Hunter College, West Room 714
FREE
Registration recommended: lnkd.in/dJY7hp-b
August 13, 2025 at 2:47 PM
The American Society for Neurochemistry (ASN) and the International Society for Neurochemistry (ISN) are hosting a discussion on autism, with clinical, research, family, & pharma perspectives.
August 17, 2025
2-4 PM
Hunter College, West Room 714
FREE
Registration recommended: lnkd.in/dJY7hp-b
August 17, 2025
2-4 PM
Hunter College, West Room 714
FREE
Registration recommended: lnkd.in/dJY7hp-b
#GliaPapers #GliaAugust2025 @wiley.com
AUGUST COVER
Oligodendrocyte binds to laminin on the perivascular basement membrane in the murine cortex at the age of postnatal day 16 (red: CC-1; green: laminin alpha-2; blue: DAPI). (see Sasaki B, et al, doi.org/10.1002/glia...)
AUGUST COVER
Oligodendrocyte binds to laminin on the perivascular basement membrane in the murine cortex at the age of postnatal day 16 (red: CC-1; green: laminin alpha-2; blue: DAPI). (see Sasaki B, et al, doi.org/10.1002/glia...)
August 13, 2025 at 2:20 PM
#GliaPapers #GliaAugust2025 @wiley.com
AUGUST COVER
Oligodendrocyte binds to laminin on the perivascular basement membrane in the murine cortex at the age of postnatal day 16 (red: CC-1; green: laminin alpha-2; blue: DAPI). (see Sasaki B, et al, doi.org/10.1002/glia...)
AUGUST COVER
Oligodendrocyte binds to laminin on the perivascular basement membrane in the murine cortex at the age of postnatal day 16 (red: CC-1; green: laminin alpha-2; blue: DAPI). (see Sasaki B, et al, doi.org/10.1002/glia...)
Reposted by Shane Liddelow
Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1
July 22, 2025 at 7:15 PM
Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1
fantastic work from @melcooperphd.bsky.social - what are these beautiful networks doing in our brains?
Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1
July 22, 2025 at 8:08 PM
fantastic work from @melcooperphd.bsky.social - what are these beautiful networks doing in our brains?
Was a lot of fun working on this piece with Ben Clayton for @annualreviews.bsky.social
Reactive astrocyte heterogeneity is a thoroughly exciting and complicated problem... lots of exciting discoveries in recent years.
www.annualreviews.org/content/jour...
Reactive astrocyte heterogeneity is a thoroughly exciting and complicated problem... lots of exciting discoveries in recent years.
www.annualreviews.org/content/jour...
July 18, 2025 at 7:31 PM
Was a lot of fun working on this piece with Ben Clayton for @annualreviews.bsky.social
Reactive astrocyte heterogeneity is a thoroughly exciting and complicated problem... lots of exciting discoveries in recent years.
www.annualreviews.org/content/jour...
Reactive astrocyte heterogeneity is a thoroughly exciting and complicated problem... lots of exciting discoveries in recent years.
www.annualreviews.org/content/jour...
On now, last session of #Glia2025, and last presenter from the lab.
S26 | Exploring glial diversity using single cell and spatial genomics
@mrodea.bsky.social
10:00 S26-01 Multi-omic definition of astrocyte diversity in the healthy and inflamed brain
S26 | Exploring glial diversity using single cell and spatial genomics
@mrodea.bsky.social
10:00 S26-01 Multi-omic definition of astrocyte diversity in the healthy and inflamed brain
July 11, 2025 at 8:11 AM
On now, last session of #Glia2025, and last presenter from the lab.
S26 | Exploring glial diversity using single cell and spatial genomics
@mrodea.bsky.social
10:00 S26-01 Multi-omic definition of astrocyte diversity in the healthy and inflamed brain
S26 | Exploring glial diversity using single cell and spatial genomics
@mrodea.bsky.social
10:00 S26-01 Multi-omic definition of astrocyte diversity in the healthy and inflamed brain
#glia2025 Liddelow Lab presentations start today!
PS2 | Poster Session II
Wednesday, 9 July 2025, 13:00 - 16:00
Room: Hall Garden Level
T11-059B Understanding specific neuron-astrocyte interactions in neuroinflammation
@sciencelemon92.bsky.social
www.liddelowlab.com/francesco-li...
PS2 | Poster Session II
Wednesday, 9 July 2025, 13:00 - 16:00
Room: Hall Garden Level
T11-059B Understanding specific neuron-astrocyte interactions in neuroinflammation
@sciencelemon92.bsky.social
www.liddelowlab.com/francesco-li...
Francesco Limone — Liddelow Lab
www.liddelowlab.com
July 9, 2025 at 9:58 AM
#glia2025 Liddelow Lab presentations start today!
PS2 | Poster Session II
Wednesday, 9 July 2025, 13:00 - 16:00
Room: Hall Garden Level
T11-059B Understanding specific neuron-astrocyte interactions in neuroinflammation
@sciencelemon92.bsky.social
www.liddelowlab.com/francesco-li...
PS2 | Poster Session II
Wednesday, 9 July 2025, 13:00 - 16:00
Room: Hall Garden Level
T11-059B Understanding specific neuron-astrocyte interactions in neuroinflammation
@sciencelemon92.bsky.social
www.liddelowlab.com/francesco-li...
And a special bonus for #EuroGlia @gliameeting.bsky.social in #Marseilles next week - all the abstracts of the fantastic presentations are available in #Glia
onlinelibrary.wiley.com/toc/10981136...
See you all in a few days - safe travels
onlinelibrary.wiley.com/toc/10981136...
See you all in a few days - safe travels
July 3, 2025 at 3:45 PM
And a special bonus for #EuroGlia @gliameeting.bsky.social in #Marseilles next week - all the abstracts of the fantastic presentations are available in #Glia
onlinelibrary.wiley.com/toc/10981136...
See you all in a few days - safe travels
onlinelibrary.wiley.com/toc/10981136...
See you all in a few days - safe travels
#GliaPapers #GliaJuly2025
JULY COVER
Stochastically labeled astrocytes (cyan) and Müller glia (magenta) contacting blood vessels (orange) and neural cell bodies and axons bundles (green) in a mouse retina. (see Holden, JM, et al, doi.org/10.1002/glia...)
JULY COVER
Stochastically labeled astrocytes (cyan) and Müller glia (magenta) contacting blood vessels (orange) and neural cell bodies and axons bundles (green) in a mouse retina. (see Holden, JM, et al, doi.org/10.1002/glia...)
July 3, 2025 at 3:43 PM
#GliaPapers #GliaJuly2025
JULY COVER
Stochastically labeled astrocytes (cyan) and Müller glia (magenta) contacting blood vessels (orange) and neural cell bodies and axons bundles (green) in a mouse retina. (see Holden, JM, et al, doi.org/10.1002/glia...)
JULY COVER
Stochastically labeled astrocytes (cyan) and Müller glia (magenta) contacting blood vessels (orange) and neural cell bodies and axons bundles (green) in a mouse retina. (see Holden, JM, et al, doi.org/10.1002/glia...)
Thanks @analog-ashley.bsky.social and @thetransmitter.bsky.social - this was a fun piece to chat about.
Lots of exciting astrocyte work coming out of labs the world over. Watch this space for new insights soon!
Lots of exciting astrocyte work coming out of labs the world over. Watch this space for new insights soon!
After testing thousands of different molecule combinations, @liddelowsa.bsky.social cracked the code: Three cytokines are to blame.
Here’s how to break down this 2017 molecular biology paper for your students.
By @analog-ashley.bsky.social
www.thetransmitter.org/how-to-teach...
Here’s how to break down this 2017 molecular biology paper for your students.
By @analog-ashley.bsky.social
www.thetransmitter.org/how-to-teach...
How to teach this paper: ‘Neurotoxic reactive astrocytes are induced by activated microglia,’ by Liddelow et al. (2017)
Shane Liddelow and his collaborators identified the factors that transform astrocytes from their helpful to harmful form. Their work is a great choice if you want to teach students about glial cell…
www.thetransmitter.org
June 30, 2025 at 3:07 PM
Thanks @analog-ashley.bsky.social and @thetransmitter.bsky.social - this was a fun piece to chat about.
Lots of exciting astrocyte work coming out of labs the world over. Watch this space for new insights soon!
Lots of exciting astrocyte work coming out of labs the world over. Watch this space for new insights soon!
Strong recommend. Great new PI, excellent institute and resources. Exciting questions to research!
🚨🚨🚨 OPEN POSTDOC POSITION 🚨🚨🚨 in my lab!
Are you interested in understanding how the brain moves our arms?
Reach to your computer and apply!
www.mosbergerlab.com/open-positions
Are you interested in understanding how the brain moves our arms?
Reach to your computer and apply!
www.mosbergerlab.com/open-positions
Open Positions — Mosberger Lab
www.mosbergerlab.com
June 30, 2025 at 2:29 AM
Strong recommend. Great new PI, excellent institute and resources. Exciting questions to research!
Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! 👉 nyumc.qualtrics.com/jfe/form/SV_...
#Neuroscience #Postdoc #ResearchOpportunity
#Neuroscience #Postdoc #ResearchOpportunity
June 15, 2025 at 4:20 PM
Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! 👉 nyumc.qualtrics.com/jfe/form/SV_...
#Neuroscience #Postdoc #ResearchOpportunity
#Neuroscience #Postdoc #ResearchOpportunity
#GliaPapers #GliaJune2025
JUNE COVER
Mouse oligodendroglia (O4+ in green and nuclei in white) co-cultured with primary microglia (not shown in this image) after exposure to corticosterone.(See Madeira et al, doi.org/10.1002/glia...)
JUNE COVER
Mouse oligodendroglia (O4+ in green and nuclei in white) co-cultured with primary microglia (not shown in this image) after exposure to corticosterone.(See Madeira et al, doi.org/10.1002/glia...)
June 5, 2025 at 2:44 PM
#GliaPapers #GliaJune2025
JUNE COVER
Mouse oligodendroglia (O4+ in green and nuclei in white) co-cultured with primary microglia (not shown in this image) after exposure to corticosterone.(See Madeira et al, doi.org/10.1002/glia...)
JUNE COVER
Mouse oligodendroglia (O4+ in green and nuclei in white) co-cultured with primary microglia (not shown in this image) after exposure to corticosterone.(See Madeira et al, doi.org/10.1002/glia...)
Congratulations to @pryprk.bsky.social on this fantastic piece of work!
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease
Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains
is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets
and lose their phagocytic cap...
www.cell.com
May 19, 2025 at 11:51 PM
Congratulations to @pryprk.bsky.social on this fantastic piece of work!