Liana Lareau
@lianafaye.bsky.social
Associate Professor of Bioengineering, Berkeley. Living in an RNA world. lareaulab.org
Not a rule but a principle: clear thinking leads to clear writing (and vice versa)
November 20, 2025 at 1:40 AM
Not a rule but a principle: clear thinking leads to clear writing (and vice versa)
Reposted by Liana Lareau
Giant copy of the Constitution being carried down Pennsylvania Avenue.
October 18, 2025 at 4:13 PM
Giant copy of the Constitution being carried down Pennsylvania Avenue.
Reposted by Liana Lareau
mRNA vaccines are safe, have been in development for decades, & have far broader applications than older vaccine technologies.
New vaccine technologies evolve when scientists have tools & knowledge to make something more elegant or complex that wasn’t possible before.
5/
New vaccine technologies evolve when scientists have tools & knowledge to make something more elegant or complex that wasn’t possible before.
5/
August 31, 2025 at 1:06 AM
mRNA vaccines are safe, have been in development for decades, & have far broader applications than older vaccine technologies.
New vaccine technologies evolve when scientists have tools & knowledge to make something more elegant or complex that wasn’t possible before.
5/
New vaccine technologies evolve when scientists have tools & knowledge to make something more elegant or complex that wasn’t possible before.
5/
Or rather, the study section was still giving lots of good scores but the grants were just never funded. It was such a waste of so many scientists’ time on both sides.
August 20, 2025 at 4:02 PM
Or rather, the study section was still giving lots of good scores but the grants were just never funded. It was such a waste of so many scientists’ time on both sides.
Was this perhaps an NIGMS-heavy study section implementing their mostly-unannounced policy to pretty much stop funding R01s in favor of R35s (which go to different study sections)?
August 20, 2025 at 3:59 PM
Was this perhaps an NIGMS-heavy study section implementing their mostly-unannounced policy to pretty much stop funding R01s in favor of R35s (which go to different study sections)?
Yes, it's a discrete counting thing: think about the most extreme log2 fold change numbers you could observe if you start with 100 or 10 or 2 items and end up with 1 item.
August 9, 2025 at 10:24 PM
Yes, it's a discrete counting thing: think about the most extreme log2 fold change numbers you could observe if you start with 100 or 10 or 2 items and end up with 1 item.
That's really interesting - incidentally, we also have some work on how the speed of elongation might feed back on initiation (not in the context of membrane proteins, in this case, and no mechanism yet!). Definitely some interesting possibilities. www.biorxiv.org/content/10.1...
Translation elongation as a rate limiting step of protein production
The impact of synonymous codon choice on protein output has important implications for understanding endogenous gene expression and design of synthetic mRNAs. Synonymous codons are decoded at differen...
www.biorxiv.org
August 8, 2025 at 7:52 PM
That's really interesting - incidentally, we also have some work on how the speed of elongation might feed back on initiation (not in the context of membrane proteins, in this case, and no mechanism yet!). Definitely some interesting possibilities. www.biorxiv.org/content/10.1...