Anthony Leung
@leunglab.bsky.social
Professor. Science and social about my lab at Johns Hopkins University working on PARP and RNA biology. Views are my own.
Q.E.D. is fun to use and educational to reflect!
Would you consider adding a ChatBot in the interface so that we can interact with the critiques?
Thanks for creating such an amazing tool! 👏👏
Would you consider adding a ChatBot in the interface so that we can interact with the critiques?
Thanks for creating such an amazing tool! 👏👏
November 8, 2025 at 2:57 PM
Q.E.D. is fun to use and educational to reflect!
Would you consider adding a ChatBot in the interface so that we can interact with the critiques?
Thanks for creating such an amazing tool! 👏👏
Would you consider adding a ChatBot in the interface so that we can interact with the critiques?
Thanks for creating such an amazing tool! 👏👏
Just submitted for early access! Excited 😊
October 16, 2025 at 9:21 PM
Just submitted for early access! Excited 😊
Thanks - will give it a try!
October 15, 2025 at 10:45 PM
Thanks - will give it a try!
How to get access?
October 15, 2025 at 9:00 PM
How to get access?
Thanks Waters, SCIEX, Seer, Proteintech and Avantor for sponsorship!!
May 10, 2025 at 1:10 PM
Thanks Waters, SCIEX, Seer, Proteintech and Avantor for sponsorship!!
Thanks Mike - also we saw ubiquitin involvement here - it will be interesting to see whether it related to your nice work on protein-conjugated ADP-ribose directly linked to ubiquitin. Need another nice bakery to chat more :-)
doi.org/10.1038/s443...
doi.org/10.1038/s443...
Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose | The EMBO Journal
imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and
ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification
has remained ...
doi.org
April 8, 2025 at 3:02 PM
Thanks Mike - also we saw ubiquitin involvement here - it will be interesting to see whether it related to your nice work on protein-conjugated ADP-ribose directly linked to ubiquitin. Need another nice bakery to chat more :-)
doi.org/10.1038/s443...
doi.org/10.1038/s443...
For #condensate folks 👀
Our study tackles a key gap: how condensate composition is regulated.
These p62 bodies require PARP14—but it’s not just presence that matters.
It’s PARP14’s enzymatic activity that drives formation.
In fact, more PARP14 without activity ≠ condensation.
Our study tackles a key gap: how condensate composition is regulated.
These p62 bodies require PARP14—but it’s not just presence that matters.
It’s PARP14’s enzymatic activity that drives formation.
In fact, more PARP14 without activity ≠ condensation.
April 8, 2025 at 1:43 AM
For #condensate folks 👀
Our study tackles a key gap: how condensate composition is regulated.
These p62 bodies require PARP14—but it’s not just presence that matters.
It’s PARP14’s enzymatic activity that drives formation.
In fact, more PARP14 without activity ≠ condensation.
Our study tackles a key gap: how condensate composition is regulated.
These p62 bodies require PARP14—but it’s not just presence that matters.
It’s PARP14’s enzymatic activity that drives formation.
In fact, more PARP14 without activity ≠ condensation.
Why it matters 👇
p62 bodies are key hubs for protein degradation & immune signaling—long linked to #cancer & #neurodegeneration.
Our study shows interferon + PARP14-driven ADP-ribosylation rewires their formation, revealing a new immune-regulated condensate class.
p62 bodies are key hubs for protein degradation & immune signaling—long linked to #cancer & #neurodegeneration.
Our study shows interferon + PARP14-driven ADP-ribosylation rewires their formation, revealing a new immune-regulated condensate class.
April 8, 2025 at 1:43 AM
Why it matters 👇
p62 bodies are key hubs for protein degradation & immune signaling—long linked to #cancer & #neurodegeneration.
Our study shows interferon + PARP14-driven ADP-ribosylation rewires their formation, revealing a new immune-regulated condensate class.
p62 bodies are key hubs for protein degradation & immune signaling—long linked to #cancer & #neurodegeneration.
Our study shows interferon + PARP14-driven ADP-ribosylation rewires their formation, revealing a new immune-regulated condensate class.
Great work from Dr. Isabel Uribe, based on her PhD thesis research! 🎓 With collaborations across three top proteomics teams led by Chan Hyun Na, Benjamin A. Garcia @garcialabms.bsky.social & her co-mentor, Benjamin C. Orsburn @proteomicsnews.bsky.social. 🎉
March 13, 2025 at 12:09 PM
Great work from Dr. Isabel Uribe, based on her PhD thesis research! 🎓 With collaborations across three top proteomics teams led by Chan Hyun Na, Benjamin A. Garcia @garcialabms.bsky.social & her co-mentor, Benjamin C. Orsburn @proteomicsnews.bsky.social. 🎉