Quantitative semiology: harnessing AI-generated teaching signals in psychiatry cdnsciencepub.com/doi/10.1139/...
Quantitative semiology: harnessing AI-generated teaching signals in psychiatry
cdnsciencepub.com
October 25, 2025 at 12:44 AM
Quantitative semiology: harnessing AI-generated teaching signals in psychiatry cdnsciencepub.com/doi/10.1139/...
Reposted by Lena Palaniyappan
New review paper on theory of mind/mentalizing and spontaneous speech/language. Led by Chaimaa El Mouslih, and co-authored with @vegashodgins.bsky.social and @lenapl.bsky.social
www.mdpi.com/2076-328X/15...
www.mdpi.com/2076-328X/15...
www.mdpi.com
July 28, 2025 at 12:40 PM
New review paper on theory of mind/mentalizing and spontaneous speech/language. Led by Chaimaa El Mouslih, and co-authored with @vegashodgins.bsky.social and @lenapl.bsky.social
www.mdpi.com/2076-328X/15...
www.mdpi.com/2076-328X/15...
Reposted by Lena Palaniyappan
Check out this 🆕 paper form @lenapl.bsky.social et al showing that speech spectrograms can track negative symptom severity in schizophrenia
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Taking a look at your speech: identifying diagnostic status and negative symptoms of psychosis using convolutional neural networks - NPP—Digital Psychiatry and Neuroscience
Short snippets of everyday speech hold medical clues. Using computer vision techniques on sound pictures (“spectrograms”) from short speech fragments, researchers trained a neural network on recording...
www.nature.com
July 9, 2025 at 1:36 PM
Check out this 🆕 paper form @lenapl.bsky.social et al showing that speech spectrograms can track negative symptom severity in schizophrenia
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Reposted by Lena Palaniyappan
🚨 NEW RESEARCH! ⚕️ 🩺 🧠
Elleuch et al. explore the association of grammatical challenges in people with Schizophrenia in a systematic review and meta-analysis of 45 studies.
https://bit.ly/4kZnq66
@lenapl.bsky.social
Elleuch et al. explore the association of grammatical challenges in people with Schizophrenia in a systematic review and meta-analysis of 45 studies.
https://bit.ly/4kZnq66
@lenapl.bsky.social
Relationship between grammar and schizophrenia: a systematic review and meta-analysis - Communications Medicine
Elleuch et al, perform a systematic review and meta-analysis to evaluate the association between grammatical impairments and schizophrenia. Large effect size deficits in grammatical comprehension and production occur in this illness, highlighting the need for targeted interventions to address language use in people with psychotic disorders.
bit.ly
June 23, 2025 at 11:31 AM
🚨 NEW RESEARCH! ⚕️ 🩺 🧠
Elleuch et al. explore the association of grammatical challenges in people with Schizophrenia in a systematic review and meta-analysis of 45 studies.
https://bit.ly/4kZnq66
@lenapl.bsky.social
Elleuch et al. explore the association of grammatical challenges in people with Schizophrenia in a systematic review and meta-analysis of 45 studies.
https://bit.ly/4kZnq66
@lenapl.bsky.social
One of the largest longitudinal study of computational speech and language features and psychosis from @stanglab.bsky.social Tang & colleagues! www.nature.com/articles/s44...
Automated speech and language markers of longitudinal changes in psychosis symptoms - NPP—Digital Psychiatry and Neuroscience
We used acoustic analysis and Natural Language Processing (NLP) to evaluate speech data from 66 individuals with psychosis, over time. The study identified specific language features that correlate wi...
www.nature.com
June 17, 2025 at 2:01 PM
One of the largest longitudinal study of computational speech and language features and psychosis from @stanglab.bsky.social Tang & colleagues! www.nature.com/articles/s44...
Reposted by Lena Palaniyappan
#ThisWeekInNPP
This study identified a prefrontal-limbic structural covariance network with ⬇️ gray matter volume specific to treatment-resistant schizophrenia, linked to serotonergic, glutamatergic, histaminergic, & opioid receptor distributions 🧠
www.nature.com/articles/s41...
This study identified a prefrontal-limbic structural covariance network with ⬇️ gray matter volume specific to treatment-resistant schizophrenia, linked to serotonergic, glutamatergic, histaminergic, & opioid receptor distributions 🧠
www.nature.com/articles/s41...
Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis - Neuropsychopharmacology
Neuropsychopharmacology - Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis
www.nature.com
June 3, 2025 at 10:05 PM
#ThisWeekInNPP
This study identified a prefrontal-limbic structural covariance network with ⬇️ gray matter volume specific to treatment-resistant schizophrenia, linked to serotonergic, glutamatergic, histaminergic, & opioid receptor distributions 🧠
www.nature.com/articles/s41...
This study identified a prefrontal-limbic structural covariance network with ⬇️ gray matter volume specific to treatment-resistant schizophrenia, linked to serotonergic, glutamatergic, histaminergic, & opioid receptor distributions 🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
People with schizophrenia that is resistant to treatment may have specific prefrontal-limbic brain deficits linked to non-dopaminergic neurotransmitter systems—highlighting the need for therapies beyond antipsychotics. #schizophrenia #neuroscience #mentalhealth
People with schizophrenia that is resistant to treatment may have specific prefrontal-limbic brain deficits linked to non-dopaminergic neurotransmitter systems—highlighting the need for therapies beyond antipsychotics. #schizophrenia #neuroscience #mentalhealth
Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis - Neuropsychopharmacology
Neuropsychopharmacology - Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis
www.nature.com
May 28, 2025 at 10:33 PM
www.nature.com/articles/s41...
People with schizophrenia that is resistant to treatment may have specific prefrontal-limbic brain deficits linked to non-dopaminergic neurotransmitter systems—highlighting the need for therapies beyond antipsychotics. #schizophrenia #neuroscience #mentalhealth
People with schizophrenia that is resistant to treatment may have specific prefrontal-limbic brain deficits linked to non-dopaminergic neurotransmitter systems—highlighting the need for therapies beyond antipsychotics. #schizophrenia #neuroscience #mentalhealth
Reposted by Lena Palaniyappan
Very, very obviously we need to emphasize science-informed preventative strategies.
Public health experts – myself included – have focused on this for decades!
But phrase "root causes" long ago morphed into a red flag for bunk. 🚩
news.immunologic.org/p/real-root-... @drandrealove.bsky.social👇
Public health experts – myself included – have focused on this for decades!
But phrase "root causes" long ago morphed into a red flag for bunk. 🚩
news.immunologic.org/p/real-root-... @drandrealove.bsky.social👇
Real root cause medicine is based on science, not wellness disinformation.
RFK Jr, Marty Makary, and MAHA allies are lying to you. Biomedical research is BASED ON identifying and treating underlying causes of illness.
news.immunologic.org
May 24, 2025 at 3:20 PM
Very, very obviously we need to emphasize science-informed preventative strategies.
Public health experts – myself included – have focused on this for decades!
But phrase "root causes" long ago morphed into a red flag for bunk. 🚩
news.immunologic.org/p/real-root-... @drandrealove.bsky.social👇
Public health experts – myself included – have focused on this for decades!
But phrase "root causes" long ago morphed into a red flag for bunk. 🚩
news.immunologic.org/p/real-root-... @drandrealove.bsky.social👇
Reposted by Lena Palaniyappan
Congratulations to @lenapl.bsky.social, @sylvainbaillet.bsky.social and the whole team on the boost from the @wellcometrust.bsky.social for the DIALOG initiative douglas.research.mcgill.ca/news/underst...
Understanding Psychiatric Disorders Through Language: $9.8M from The Wellcome Trust for DIALOG Initiative - The Douglas Research Centre
Montreal, April 23, 2025 The Douglas Mental Health University Institute is proud to announce that the Wellcome Trust has awarded $9.8 million to Dr. Lena Palaniyappan in support of ... Read more
douglas.research.mcgill.ca
May 20, 2025 at 1:36 PM
Congratulations to @lenapl.bsky.social, @sylvainbaillet.bsky.social and the whole team on the boost from the @wellcometrust.bsky.social for the DIALOG initiative douglas.research.mcgill.ca/news/underst...
Reposted by Lena Palaniyappan
Drs. Peter Van Dyken and Lena Palaniyappan (@lenapl.bsky.social) (@schulichmeddent.bsky.social)'s research trainee study on graph theory and U-fibre network in people with #Schizophrenia: www.psifoundation.org/funded-resea... #SchizophreniaResearch
Funded Research - PSI Foundation
List of projects funded by PSI Foundation.
www.psifoundation.org
May 23, 2025 at 5:06 PM
Drs. Peter Van Dyken and Lena Palaniyappan (@lenapl.bsky.social) (@schulichmeddent.bsky.social)'s research trainee study on graph theory and U-fibre network in people with #Schizophrenia: www.psifoundation.org/funded-resea... #SchizophreniaResearch
Excellent synergy here, looking forward to it @sylvainbaillet.bsky.social !
Looking forward to working with @lenapl.bsky.social through this transformative grant from @wellcometrust.bsky.social, leveraging LLMs and time-resolved imaging of natural speech processes in psychotic disorders.
www.neurospeed-bailletlab.org/news/dialog-...
@mcgill.ca @theneuro.bsky.social
www.neurospeed-bailletlab.org/news/dialog-...
@mcgill.ca @theneuro.bsky.social
Probing Language Brain Processes in Psychosis — Baillet Lab [ neuroSPEED ]
Backed by a $9.8M transformative grant from the Wellcome Trust , we are joining the DIALOG initiative to uncover how the brain predicts language in real time. Using MEG and AI-based language models, ...
www.neurospeed-bailletlab.org
May 6, 2025 at 1:25 PM
Excellent synergy here, looking forward to it @sylvainbaillet.bsky.social !
Reposted by Lena Palaniyappan
Western University is seeking applications for Canada Excellence Research Chairs. Please reach out if you are interested in Theme 2: Neuroscience. Western has extraordinary strengths in cognitive, molecular and systems neuroscience across species (rodents, NHPs, humans) uwo.ca/research/cer...
May 5, 2025 at 10:47 PM
Western University is seeking applications for Canada Excellence Research Chairs. Please reach out if you are interested in Theme 2: Neuroscience. Western has extraordinary strengths in cognitive, molecular and systems neuroscience across species (rodents, NHPs, humans) uwo.ca/research/cer...
Reposted by Lena Palaniyappan
Greening the lab:
Researchers are a group that can take concrete steps to reduce the environmental footprint associated with their activities.
➡️
www.jpn.ca/lookup/doi/1...
Researchers are a group that can take concrete steps to reduce the environmental footprint associated with their activities.
➡️
www.jpn.ca/lookup/doi/1...
April 25, 2025 at 2:55 PM
Greening the lab:
Researchers are a group that can take concrete steps to reduce the environmental footprint associated with their activities.
➡️
www.jpn.ca/lookup/doi/1...
Researchers are a group that can take concrete steps to reduce the environmental footprint associated with their activities.
➡️
www.jpn.ca/lookup/doi/1...
Reposted by Lena Palaniyappan
Topiramate for treatment of behavioural disorders in Prader–Willi syndrome:
Topiramate is effective in treating compulsive behaviours associated with PWS, but requires monitoring.
➡️
www.jpn.ca/lookup/doi/1...
Topiramate is effective in treating compulsive behaviours associated with PWS, but requires monitoring.
➡️
www.jpn.ca/lookup/doi/1...
April 28, 2025 at 1:55 PM
Topiramate for treatment of behavioural disorders in Prader–Willi syndrome:
Topiramate is effective in treating compulsive behaviours associated with PWS, but requires monitoring.
➡️
www.jpn.ca/lookup/doi/1...
Topiramate is effective in treating compulsive behaviours associated with PWS, but requires monitoring.
➡️
www.jpn.ca/lookup/doi/1...
Reposted by Lena Palaniyappan
📣 We are proud to announce that the Wellcome Trust has awarded Dr. Palaniyappan!
📣 Nous sommes fiers d’annoncer l'obtention d'une subvention de la Fondation Wellcome Trust à Dr Palaniyappan pour soutenir le projet DIALOG!
More infos / plus d'infos :
douglas.research.mcgill.ca/news/underst...
📣 Nous sommes fiers d’annoncer l'obtention d'une subvention de la Fondation Wellcome Trust à Dr Palaniyappan pour soutenir le projet DIALOG!
More infos / plus d'infos :
douglas.research.mcgill.ca/news/underst...
April 24, 2025 at 3:03 PM
📣 We are proud to announce that the Wellcome Trust has awarded Dr. Palaniyappan!
📣 Nous sommes fiers d’annoncer l'obtention d'une subvention de la Fondation Wellcome Trust à Dr Palaniyappan pour soutenir le projet DIALOG!
More infos / plus d'infos :
douglas.research.mcgill.ca/news/underst...
📣 Nous sommes fiers d’annoncer l'obtention d'une subvention de la Fondation Wellcome Trust à Dr Palaniyappan pour soutenir le projet DIALOG!
More infos / plus d'infos :
douglas.research.mcgill.ca/news/underst...
We show cannabis use disorder is associated with higher midbrain neuromelanin, where such an increase is associated with #psychosis severity. The higher the use, the greater the putative dopamine turnover.
Led by Jessica Ahrens @healthsciences.mcgill.ca IPN
jamanetwork.com/journals/jam...
Led by Jessica Ahrens @healthsciences.mcgill.ca IPN
jamanetwork.com/journals/jam...
Convergence of Cannabis and Psychosis on the Dopamine System
This cohort study investigates the association between cannabis and the midbrain dopamine pathway involved in psychosis.
jamanetwork.com
April 9, 2025 at 6:16 PM
We show cannabis use disorder is associated with higher midbrain neuromelanin, where such an increase is associated with #psychosis severity. The higher the use, the greater the putative dopamine turnover.
Led by Jessica Ahrens @healthsciences.mcgill.ca IPN
jamanetwork.com/journals/jam...
Led by Jessica Ahrens @healthsciences.mcgill.ca IPN
jamanetwork.com/journals/jam...
When we are depressed, we not only have negative thoughts but also experience a muddled, disorganized thinking process. We propose some steps to make progress in understanding and reducing the burden of disorganization in #Depression
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Disorganisation and depression: a re-examination of how we think and speak when depressed - European Archives of Psychiatry and Clinical Neuroscience
Disorganised thinking in severe mental illness seriously cripples social functions. Historically, the study of disorganisation has primarily concentrated on schizophrenia, utilizing tools designed to ...
link.springer.com
April 3, 2025 at 3:46 AM
When we are depressed, we not only have negative thoughts but also experience a muddled, disorganized thinking process. We propose some steps to make progress in understanding and reducing the burden of disorganization in #Depression
link.springer.com/article/10.1...
link.springer.com/article/10.1...
www.sciencedirect.com/science/arti...
We see a prominent excess of first-person pronouns in #schizophrenia, with no excessive inter-individual variability. While not a direct comparison, this effect (d=0.89) is >> than striatal dopamine excess or prefrontal glutamate reduction reported to date.
We see a prominent excess of first-person pronouns in #schizophrenia, with no excessive inter-individual variability. While not a direct comparison, this effect (d=0.89) is >> than striatal dopamine excess or prefrontal glutamate reduction reported to date.
Speaking of yourself: A meta-analysis of 80 years of research on pronoun use in schizophrenia
People with schizophrenia experience significant language disturbances that profoundly affect their everyday social interactions. Given its relevance …
www.sciencedirect.com
March 28, 2025 at 10:58 AM
www.sciencedirect.com/science/arti...
We see a prominent excess of first-person pronouns in #schizophrenia, with no excessive inter-individual variability. While not a direct comparison, this effect (d=0.89) is >> than striatal dopamine excess or prefrontal glutamate reduction reported to date.
We see a prominent excess of first-person pronouns in #schizophrenia, with no excessive inter-individual variability. While not a direct comparison, this effect (d=0.89) is >> than striatal dopamine excess or prefrontal glutamate reduction reported to date.
Dog person
On what the RCMP allegedly did to thousands of sled dogs
open.substack.com
March 23, 2025 at 8:11 PM
Transcriptional substrates of cortical thickness alterations in anhedonia of #depression ... www.sciencedirect.com/science/arti...
Transcriptional substrates of cortical thickness alterations in anhedonia of major depressive disorder
Anhedonia is a core symptom of major depressive disorder (MDD), which has been shown to be associated with abnormalities in cortical morphology. Howev…
www.sciencedirect.com
March 6, 2025 at 1:34 PM
Transcriptional substrates of cortical thickness alterations in anhedonia of #depression ... www.sciencedirect.com/science/arti...
