Léa Bernaleau
@lbernaleau.bsky.social
PhD student studying innate immunity, autoimmunity, TLRs, & SLCs.
Research at @rebsamenlab.bsky.social | @dib-unil.bsky.social
https://rebsamenlab.org/
Research at @rebsamenlab.bsky.social | @dib-unil.bsky.social
https://rebsamenlab.org/
Pinned
Léa Bernaleau
@lbernaleau.bsky.social
· Dec 10
I’m proud to share the latest work of my PhD thesis, just published in @jexpmed.bsky.social! You’ll find how CCDC134 controls TLR biogenesis through the ER-chaperone Gp96, a very exciting discovery!
rupress.org/jem/article-...
More info here: bsky.app/profile/rebs...
rupress.org/jem/article-...
More info here: bsky.app/profile/rebs...
Reposted by Léa Bernaleau
Reposted by Léa Bernaleau
Check out the Insights piece from A Blumenthal & L Dominguez Cadena on our discovery of CCDC134’s role in Gp96 stability and TLR biogenesis.
Many thanks to the authors for discussing our work broadly, integrating recent studies by Rohatgi and Locher/Kaelin labs, and highlighting key open questions.
Many thanks to the authors for discussing our work broadly, integrating recent studies by Rohatgi and Locher/Kaelin labs, and highlighting key open questions.
February 10, 2025 at 2:05 PM
Check out the Insights piece from A Blumenthal & L Dominguez Cadena on our discovery of CCDC134’s role in Gp96 stability and TLR biogenesis.
Many thanks to the authors for discussing our work broadly, integrating recent studies by Rohatgi and Locher/Kaelin labs, and highlighting key open questions.
Many thanks to the authors for discussing our work broadly, integrating recent studies by Rohatgi and Locher/Kaelin labs, and highlighting key open questions.
Thrilled to see our recent paper on CCDC134 highlighted in @jem.org !
Grateful for the opportunity to contribute to this field and engage in meaningful discussions!
Grateful for the opportunity to contribute to this field and engage in meaningful discussions!
Insights from Cadena & Blumenthal: Bernaleau et al. @rebsamenlab.bsky.social (https://buff.ly/3ZrE70d) show that CCDC134 located in the ER is required for TLR biogenesis by controlling the N-glycosylation, folding, and stabilization of the ER chaperone Gp96. https://buff.ly/4gwjt5N
February 5, 2025 at 8:23 PM
Thrilled to see our recent paper on CCDC134 highlighted in @jem.org !
Grateful for the opportunity to contribute to this field and engage in meaningful discussions!
Grateful for the opportunity to contribute to this field and engage in meaningful discussions!
Reposted by Léa Bernaleau
We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland.
Registrations open March 1 - Attendance limited to 150 participants.
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
Registrations open March 1 - Attendance limited to 150 participants.
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
Symposium immunobiology
wp.unil.ch
January 28, 2025 at 2:33 PM
We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland.
Registrations open March 1 - Attendance limited to 150 participants.
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
Registrations open March 1 - Attendance limited to 150 participants.
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
Reposted by Léa Bernaleau
Check out our latest pre print! Alexandra and colleagues show that the enigmatic inflammasome receptor, NLRP6 is activated by sterile and pathogen induced endolysosomal damage. Hot off the press!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cells
NLRP6 controls host defense against bacteria and viruses in the gastrointestinal tract by a poorly understood mechanism. Here, we report that NLRP6 forms an inflammasome upon endolysosomal damage caus...
www.biorxiv.org
January 28, 2025 at 1:42 PM
Check out our latest pre print! Alexandra and colleagues show that the enigmatic inflammasome receptor, NLRP6 is activated by sterile and pathogen induced endolysosomal damage. Hot off the press!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
I’m thrilled to share our latest work from the @rebsamenlab.bsky.social, now published in @naturecomms.bsky.social!
For the first time, we reveal the importance of the SLC15A4-TASL-IRF5 pathway in vivo.
It was a great pleasure to contribute to this project!
For the first time, we reveal the importance of the SLC15A4-TASL-IRF5 pathway in vivo.
It was a great pleasure to contribute to this project!
Excited to share our latest paper out today in @naturecomms.bsky.social !
Great work led by postdoc Ales Drobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago.
#ImmunoSky #InterferoSky
Great work led by postdoc Ales Drobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago.
#ImmunoSky #InterferoSky
The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse - Nature Communications
TASL is an adaptor molecule bridging Toll-like receptor signalling and transcription activation by IRF5. Here the authors show that TASL deficiency impacts TLR7/9 responses, and that a TASL paralogue,...
www.nature.com
January 25, 2025 at 5:51 PM
I’m thrilled to share our latest work from the @rebsamenlab.bsky.social, now published in @naturecomms.bsky.social!
For the first time, we reveal the importance of the SLC15A4-TASL-IRF5 pathway in vivo.
It was a great pleasure to contribute to this project!
For the first time, we reveal the importance of the SLC15A4-TASL-IRF5 pathway in vivo.
It was a great pleasure to contribute to this project!
Reposted by Léa Bernaleau
📢We're recruiting📢
Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!
Please share
#uridine #cancermetabolism #immunometabolism
@unil.bsky.social
🔗(PDF): www.jourdainlab.org/wp-content/u...
Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!
Please share
#uridine #cancermetabolism #immunometabolism
@unil.bsky.social
🔗(PDF): www.jourdainlab.org/wp-content/u...
December 16, 2024 at 11:13 AM
📢We're recruiting📢
Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!
Please share
#uridine #cancermetabolism #immunometabolism
@unil.bsky.social
🔗(PDF): www.jourdainlab.org/wp-content/u...
Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!
Please share
#uridine #cancermetabolism #immunometabolism
@unil.bsky.social
🔗(PDF): www.jourdainlab.org/wp-content/u...
I’m proud to share the latest work of my PhD thesis, just published in @jexpmed.bsky.social! You’ll find how CCDC134 controls TLR biogenesis through the ER-chaperone Gp96, a very exciting discovery!
rupress.org/jem/article-...
More info here: bsky.app/profile/rebs...
rupress.org/jem/article-...
More info here: bsky.app/profile/rebs...
December 10, 2024 at 4:18 PM
I’m proud to share the latest work of my PhD thesis, just published in @jexpmed.bsky.social! You’ll find how CCDC134 controls TLR biogenesis through the ER-chaperone Gp96, a very exciting discovery!
rupress.org/jem/article-...
More info here: bsky.app/profile/rebs...
rupress.org/jem/article-...
More info here: bsky.app/profile/rebs...