Ben Lane
@lane-b.bsky.social
Research Fellow at the Aston Institute for Membrane Excellence. Membrane proteins and structural biology.
Reposted by Ben Lane
3.5 yr funded PhD studentship available in my lab October start. Exploring cardiac myosin modulators with cryoEM and mass spec. Get in touch if interested. Apply before 28th July. www.findaphd.com/phds/project...
Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds on FindAPhD.com
PhD Project - Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds, listed on FindAPhD.com
www.findaphd.com
June 16, 2025 at 6:54 PM
3.5 yr funded PhD studentship available in my lab October start. Exploring cardiac myosin modulators with cryoEM and mass spec. Get in touch if interested. Apply before 28th July. www.findaphd.com/phds/project...
Reposted by Ben Lane
I’m very happy to share my first paper on the effects of AWI interactions and flexibility on SPA data quality! Thank you to everyone on the team 🤩
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Untangling the effects of flexibility and the AWI in cryoEM sample preparation: A case study using KtrA
Single particle cryo-electron microscopy (cryoEM) is a powerful tool for elucidating the structures of biological macromolecules without requiring cry…
www.sciencedirect.com
June 2, 2025 at 5:18 PM
I’m very happy to share my first paper on the effects of AWI interactions and flexibility on SPA data quality! Thank you to everyone on the team 🤩
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Ben Lane
You can pry my em dashes — one of my favorite punctuation marks and one I often use — from my cold, dead keyboard.
Stop spreading this garbage about em dashes in ACTUAL EDITED PROSE OH MY GOD.
Plenty of actual human beings know how to type em dashes! We’re called “writers” and “editors” — maybe you’ve heard of us?
Plenty of actual human beings know how to type em dashes! We’re called “writers” and “editors” — maybe you’ve heard of us?
July 7, 2025 at 1:53 AM
You can pry my em dashes — one of my favorite punctuation marks and one I often use — from my cold, dead keyboard.
Reposted by Ben Lane
I started on this around 2006 so only taken 20 years! The project itself started over 30 years ago. Great to finally see the elusive structure.
Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social
Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature
A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...
www.nature.com
April 10, 2025 at 1:46 PM
I started on this around 2006 so only taken 20 years! The project itself started over 30 years ago. Great to finally see the elusive structure.
📢 Just over 3 weeks left to apply for a 4-year funded PhD position at @astonaime.bsky.social for October 2025. Come study protein-lipid interactions in mechanosensitive channels with me, Dr. Alice Rothnie, and Prof. Corinne Spickett 📢
📅 Application deadline: 7th April 2025
tinyurl.com/4arujyaw
📅 Application deadline: 7th April 2025
tinyurl.com/4arujyaw
Investigation of lipid-protein interactions within mechanosensitive ion channels at Aston University on FindAPhD.com
PhD Project - Investigation of lipid-protein interactions within mechanosensitive ion channels at Aston University, listed on FindAPhD.com
tinyurl.com
March 15, 2025 at 5:09 PM
📢 Just over 3 weeks left to apply for a 4-year funded PhD position at @astonaime.bsky.social for October 2025. Come study protein-lipid interactions in mechanosensitive channels with me, Dr. Alice Rothnie, and Prof. Corinne Spickett 📢
📅 Application deadline: 7th April 2025
tinyurl.com/4arujyaw
📅 Application deadline: 7th April 2025
tinyurl.com/4arujyaw
📢 4-year funded PhD opportunity at the Aston Institute for Membrane Excellence, starting in October 2025. The project will focus on studying protein-lipid interactions in mechanosensitive channels📢
📅 Application deadline: 7th April 2025
@astonaime.bsky.social
tinyurl.com/4arujyaw
📅 Application deadline: 7th April 2025
@astonaime.bsky.social
tinyurl.com/4arujyaw
Investigation of lipid-protein interactions within mechanosensitive ion channels at Aston University on FindAPhD.com
PhD Project - Investigation of lipid-protein interactions within mechanosensitive ion channels at Aston University, listed on FindAPhD.com
tinyurl.com
February 28, 2025 at 9:16 AM
📢 4-year funded PhD opportunity at the Aston Institute for Membrane Excellence, starting in October 2025. The project will focus on studying protein-lipid interactions in mechanosensitive channels📢
📅 Application deadline: 7th April 2025
@astonaime.bsky.social
tinyurl.com/4arujyaw
📅 Application deadline: 7th April 2025
@astonaime.bsky.social
tinyurl.com/4arujyaw
Take a look at our new paper! We show that YbiO can achieve a conductance equivalent to MscL, the largest known gated ion channel. We also show the presence of several subconducting states. One state is consistent with a structure we determine using cryoEM.
www.cell.com/structure/fu...
www.cell.com/structure/fu...
The mechanosensitive channel YbiO has a conductance equivalent to the largest gated-pore
Lane et al. demonstrate that the mechanosensitive channel YbiO can achieve conductances
equivalent to the largest gated-pore in nature when subjected to membrane tension.
Single-channel analysis shows...
www.cell.com
February 15, 2025 at 12:42 PM
Take a look at our new paper! We show that YbiO can achieve a conductance equivalent to MscL, the largest known gated ion channel. We also show the presence of several subconducting states. One state is consistent with a structure we determine using cryoEM.
www.cell.com/structure/fu...
www.cell.com/structure/fu...
Reposted by Ben Lane
Hi Folks!
I'm actively seeking a new position, either in the UK/Europe or outside of the government in the US.
Please share with whomever and pass the word along! 🙏
www.linkedin.com/posts/hesket...
I'm actively seeking a new position, either in the UK/Europe or outside of the government in the US.
Please share with whomever and pass the word along! 🙏
www.linkedin.com/posts/hesket...
Sophie Hesketh on LinkedIn: #opentowork
Hi everyone! I'm actively seeking an academic or industrial position either back in the UK/Europe, or outside of the government in the US.
I have strong…
www.linkedin.com
February 10, 2025 at 6:55 PM
Hi Folks!
I'm actively seeking a new position, either in the UK/Europe or outside of the government in the US.
Please share with whomever and pass the word along! 🙏
www.linkedin.com/posts/hesket...
I'm actively seeking a new position, either in the UK/Europe or outside of the government in the US.
Please share with whomever and pass the word along! 🙏
www.linkedin.com/posts/hesket...
Reposted by Ben Lane
New job, new social media. I recently became a lecturer in Biosciences at Aston. I'm incredibly lucky to be associated with @astonaime.bsky.social and am looking forward to many new membrane protein adventures as I set up my lab for the first time.
December 18, 2024 at 8:26 AM
New job, new social media. I recently became a lecturer in Biosciences at Aston. I'm incredibly lucky to be associated with @astonaime.bsky.social and am looking forward to many new membrane protein adventures as I set up my lab for the first time.
Reposted by Ben Lane
Preprint is up! www.biorxiv.org/content/10.1... Trevor Docter + Ben Sorum found cannabinoids inhibit mechanosensitive K+ channels, including TRAAK mutants that cause epilepsy and FHEIG in humans. #ephys and #cryoem shows CBD competes with lipids to bind inside the channel cavity and block the pore.
December 10, 2024 at 5:59 PM
Preprint is up! www.biorxiv.org/content/10.1... Trevor Docter + Ben Sorum found cannabinoids inhibit mechanosensitive K+ channels, including TRAAK mutants that cause epilepsy and FHEIG in humans. #ephys and #cryoem shows CBD competes with lipids to bind inside the channel cavity and block the pore.
Reposted by Ben Lane
Please share, we have #PhD opportunities for anyone interested in filming the #Biophysics of life at the nanoscale.
Full details at: heath-afm-lab.github.io/positions/
Projects based around developing and applying High-Speed Atomic Force Microscopy methods to understand molecular dynamics.
Full details at: heath-afm-lab.github.io/positions/
Projects based around developing and applying High-Speed Atomic Force Microscopy methods to understand molecular dynamics.
December 10, 2024 at 11:55 AM
Please share, we have #PhD opportunities for anyone interested in filming the #Biophysics of life at the nanoscale.
Full details at: heath-afm-lab.github.io/positions/
Projects based around developing and applying High-Speed Atomic Force Microscopy methods to understand molecular dynamics.
Full details at: heath-afm-lab.github.io/positions/
Projects based around developing and applying High-Speed Atomic Force Microscopy methods to understand molecular dynamics.