Madeline Lancaster
@lancasterlab.bsky.social
Developmental neurobiologist using cerebral #organoids to study brain size and evolution. Opinions my own.
No, I don’t have it! I know, I really MUST read it!
October 3, 2025 at 11:22 AM
No, I don’t have it! I know, I really MUST read it!
Cool, thanks for sharing! Another good example of this is the change in timing of expression of ZEB2 in human versus ape neural progenitors. It’s about timing of its expression but the protein itself isn’t different. I think this is much more common as an evolutionary mechanism.
October 3, 2025 at 9:15 AM
Cool, thanks for sharing! Another good example of this is the change in timing of expression of ZEB2 in human versus ape neural progenitors. It’s about timing of its expression but the protein itself isn’t different. I think this is much more common as an evolutionary mechanism.
I can’t wait to try this! It’s such a huge issue in the field, and we haven’t been happy with any of the solutions out there so far. Thanks Yoav!
June 7, 2025 at 8:12 AM
I can’t wait to try this! It’s such a huge issue in the field, and we haven’t been happy with any of the solutions out there so far. Thanks Yoav!
FWIW, not every single SCB talks that way. @djabaudon.bsky.social and I discussed what the differences (not failures) of organoids can teach us about what cells are capable of if given the opportunity (if in vivo constraints are removed) in this article many years back: doi.org/10.1242/dev....
Exploring landscapes of brain morphogenesis with organoids
Summary: This Spotlight summarizes the themes that emerged from a recent workshop organized by The Company of Biologists on ‘Thinking beyond the dish: taking in vitro neural differentiation to the nex...
doi.org
May 26, 2025 at 5:48 PM
FWIW, not every single SCB talks that way. @djabaudon.bsky.social and I discussed what the differences (not failures) of organoids can teach us about what cells are capable of if given the opportunity (if in vivo constraints are removed) in this article many years back: doi.org/10.1242/dev....