Soni Lacefield
@lacefieldlab.bsky.social
Cell biologist | Professor at Geisel School of Medicine at Dartmouth | interested in meiosis, mitosis, cell cycle checkpoints, chromosome segregation
Reposted by Soni Lacefield
@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"
Scaling back DEI programmes and the loss of scientific talent
Nature Cell Biology - Programmes that support diversity, equity and inclusion (DEI) in science are under attack in the USA. Data indicate that diversity in the scientific workforce increases...
www.nature.com
October 23, 2025 at 4:36 PM
@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"
The Lacefield Lab won second place in the great pumpkin derby! @dartmouthbcb.bsky.social @mcbdartmouth.bsky.social
October 10, 2025 at 11:00 PM
The Lacefield Lab won second place in the great pumpkin derby! @dartmouthbcb.bsky.social @mcbdartmouth.bsky.social
Lacefield Lab grad student @pallavisgadgil.bsky.social gave an excellent talk at Geisel’s Biomedical Research Day! Congratulations Pallavi! @dartmouthbcb.bsky.social @mcbdartmouth.bsky.social
October 10, 2025 at 7:58 PM
Lacefield Lab grad student @pallavisgadgil.bsky.social gave an excellent talk at Geisel’s Biomedical Research Day! Congratulations Pallavi! @dartmouthbcb.bsky.social @mcbdartmouth.bsky.social
Just a reminder about our faculty search at Dartmouth’s Geisel School of Medicine. Applications due Oct. 15. @dartmouthbcb.bsky.social
My department at Dartmouth Medical School is hiring a tenure-track Assistant Professor. We are looking broadly for a biochemist or cell biologist. Please share this add! apply.interfolio.com/171438
@dartmouthbcb.bsky.social @futurepislack.bsky.social
@dartmouthbcb.bsky.social @futurepislack.bsky.social
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 8, 2025 at 10:23 AM
Just a reminder about our faculty search at Dartmouth’s Geisel School of Medicine. Applications due Oct. 15. @dartmouthbcb.bsky.social
Reposted by Soni Lacefield
According to news reports, NIH is on track to award nearly all of its FY25 budget. Program officers—working long hours despite staff losses—made it possible. Take a moment to thank your PO for their dedication.
September 29, 2025 at 2:32 PM
According to news reports, NIH is on track to award nearly all of its FY25 budget. Program officers—working long hours despite staff losses—made it possible. Take a moment to thank your PO for their dedication.
From MBoC: James B. Moseley (Dartmouth) shows PP2A-B56 preserves Mid1 to keep the division plane centered in fission yeast. B56 loss → rings slide & divisions become asymmetric; restoring Mid1 rescues. Paper: www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
September 29, 2025 at 10:40 PM
Check out our new manuscript on biorxiv on the role of MOS in mammalian oocyte meiosis: www.biorxiv.org/cgi/content/...
With @schindlerlab.bsky.social @giselacairobaza.bsky.social @muhammad-haseeb.bsky.social
With @schindlerlab.bsky.social @giselacairobaza.bsky.social @muhammad-haseeb.bsky.social
A persistent intracellular bridge and cell cycle misregulation enable polar body cell divisions and tumor formation in Mos-deficient eggs
Mammalian female meiosis is uniquely regulated to produce a developmentally competent egg capable of supporting embryogenesis. During meiosis I, homologous chromosomes segregate, with half extruded in...
www.biorxiv.org
August 29, 2025 at 5:34 PM
Check out our new manuscript on biorxiv on the role of MOS in mammalian oocyte meiosis: www.biorxiv.org/cgi/content/...
With @schindlerlab.bsky.social @giselacairobaza.bsky.social @muhammad-haseeb.bsky.social
With @schindlerlab.bsky.social @giselacairobaza.bsky.social @muhammad-haseeb.bsky.social
My department at Dartmouth Medical School is hiring a tenure-track Assistant Professor. We are looking broadly for a biochemist or cell biologist. Please share this add! apply.interfolio.com/171438
@dartmouthbcb.bsky.social @futurepislack.bsky.social
@dartmouthbcb.bsky.social @futurepislack.bsky.social
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
August 27, 2025 at 8:50 PM
My department at Dartmouth Medical School is hiring a tenure-track Assistant Professor. We are looking broadly for a biochemist or cell biologist. Please share this add! apply.interfolio.com/171438
@dartmouthbcb.bsky.social @futurepislack.bsky.social
@dartmouthbcb.bsky.social @futurepislack.bsky.social
Reposted by Soni Lacefield
Flybase is free to use but not free to make. It takes large teams of people and millions of dollars a year to create the knowledgebas and tools for fly research. Please donate generously.
FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...
FlyBase:Contribute to FlyBase - FlyBase Wiki
wiki.flybase.org
August 15, 2025 at 1:50 PM
Flybase is free to use but not free to make. It takes large teams of people and millions of dollars a year to create the knowledgebas and tools for fly research. Please donate generously.
Just finished teaching another year of CSHL Yeast Genetics and Genomics with a fantastic group of students as usual! @cshlcourses.bsky.social
August 15, 2025 at 9:24 PM
Just finished teaching another year of CSHL Yeast Genetics and Genomics with a fantastic group of students as usual! @cshlcourses.bsky.social
Reposted by Soni Lacefield
Meet the 14 scientists named 2025 ASCB Fellows! Honored for excellence in research, mentorship, and service, they’ll be recognized at Cell Bio 2025 this December in Philadelphia.
Read more: www.ascb.org/society-news...
Read more: www.ascb.org/society-news...
Fourteen Visionary Scientists Named 2025 ASCB Fellows - ASCB
The American Society for Cell Biology (ASCB) is proud to announce the election of 14 outstanding scientists as 2025 ASCB Fellows—a prestigious honor recognizing their exceptional contributions to cell...
www.ascb.org
August 7, 2025 at 12:02 PM
Meet the 14 scientists named 2025 ASCB Fellows! Honored for excellence in research, mentorship, and service, they’ll be recognized at Cell Bio 2025 this December in Philadelphia.
Read more: www.ascb.org/society-news...
Read more: www.ascb.org/society-news...
I have the privilege of working with these fantastic people every day! @mcbdartmouth.bsky.social @ Dartmouth Geisel School of Medicine!
July 17, 2025 at 2:06 PM
I have the privilege of working with these fantastic people every day! @mcbdartmouth.bsky.social @ Dartmouth Geisel School of Medicine!
Reposted by Soni Lacefield
The "Big Beautiful Bill" isn’t the federal budget—it’s a reconciliation bill focused on tax cuts. The real FY26 funding decisions for NIH, NSF, and more are happening now in Congress.
www.ascb.org/science-poli...
www.ascb.org/science-poli...
The "Big Beautiful Bill" is Not the Budget - ASCB
If you’ve read recent news about Congress trying to pass “the budget,” you may have noticed that even Washington, D.C. reporters don’t always have a firm grasp on the details of what they’re covering....
www.ascb.org
July 1, 2025 at 2:14 PM
The "Big Beautiful Bill" isn’t the federal budget—it’s a reconciliation bill focused on tax cuts. The real FY26 funding decisions for NIH, NSF, and more are happening now in Congress.
www.ascb.org/science-poli...
www.ascb.org/science-poli...
Reposted by Soni Lacefield
Great to see such strong support for our courageous NIH colleagues, who are standing up for science!
Today, @nihfellowsunited.bsky.social staff sent a powerful letter to the NIH Director outlining serious concerns about the agency’s direction. Thousands have already signed in support—add your name. – Mary Munson, ASCB President www.standupforscience.net/bethesda-dec...
Bethesda Declaration — STAND UP FOR SCIENCE
Support NIH Staff Now!
www.standupforscience.net
June 9, 2025 at 9:04 PM
Great to see such strong support for our courageous NIH colleagues, who are standing up for science!
Super excited to post our new publication on the role of MOS/MAPK signaling in maintaining the egg transcriptome. Great collaboration with Britt Goods lab! rep.bioscientifica.com/view/journal...
rep.bioscientifica.com
June 9, 2025 at 8:05 PM
Super excited to post our new publication on the role of MOS/MAPK signaling in maintaining the egg transcriptome. Great collaboration with Britt Goods lab! rep.bioscientifica.com/view/journal...
Scientists in GA, ASCB has scheduled a virtual Hill Day on June 25. We need scientists willing to talk to their representatives about the consequences of the proposed budget slashes. Please sign up. Or, send to colleagues. Just need to be or become ASCB members. www.ascb.org/ascb-meeting...
ASCB Georgia Virtual Capitol Hill Day
ASCB Virtual Hill Day with members of the Georgia Congressional delegation.
www.ascb.org
June 5, 2025 at 1:33 PM
Scientists in GA, ASCB has scheduled a virtual Hill Day on June 25. We need scientists willing to talk to their representatives about the consequences of the proposed budget slashes. Please sign up. Or, send to colleagues. Just need to be or become ASCB members. www.ascb.org/ascb-meeting...
Reposted by Soni Lacefield
Wow - Sharon Dent is amazing - this is so great! Congratulations Sharon ❤️
Sharon Dent inducted to the National Academy of Sciences #nas162 @ekoutelou.bsky.social @srdent47.bsky.social @angelating.bsky.social @francescacole.bsky.social
April 25, 2025 at 11:28 PM
Wow - Sharon Dent is amazing - this is so great! Congratulations Sharon ❤️
Many congratulations to @pallavisgadgil.bsky.social for being awarded the Lucille Smith award for excellence in Biochemistry. This award is in honor of the memory of Dr. Lucille Smith. The first woman at Dartmouth to attain the rank of full professor!
April 25, 2025 at 8:21 PM
Many congratulations to @pallavisgadgil.bsky.social for being awarded the Lucille Smith award for excellence in Biochemistry. This award is in honor of the memory of Dr. Lucille Smith. The first woman at Dartmouth to attain the rank of full professor!
Excited to post our new preprint on how MOS/MAPK signaling impacts the egg transcriptome! Great collaboration with Britt Goods and lab!
Disrupted MOS signaling alters meiotic cell cycle regulation and the egg transcriptome https://www.biorxiv.org/content/10.1101/2025.04.02.646881v1
April 4, 2025 at 9:13 AM
Excited to post our new preprint on how MOS/MAPK signaling impacts the egg transcriptome! Great collaboration with Britt Goods and lab!
Reposted by Soni Lacefield
🥳Just published @nature.com. Over 25 years after the discovery of SPO11 as the enzyme responsible for initiating meiotic recombination, we finally succeeded in reconstituting its DNA cleavage activity.🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SPO11 dimers are sufficient to catalyse DNA double-strand breaks in vitro - Nature
A biochemical system recapitulates the hallmarks of meiotic double-strand break formation, with mouse SPO11 catalysing break formation in the absence of any partners and remaining covalently atta...
www.nature.com
February 19, 2025 at 4:52 PM
🥳Just published @nature.com. Over 25 years after the discovery of SPO11 as the enzyme responsible for initiating meiotic recombination, we finally succeeded in reconstituting its DNA cleavage activity.🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Soni Lacefield
Super excited that my superstar friend Soni Lacefield @lacefieldlab.bsky.social is a AAAS fellow! See how her creative research is making an impact on our understanding of meiosis and infertility.
geiselmed.dartmouth.edu/news/2025/so...
geiselmed.dartmouth.edu/news/2025/so...
Soni Lacefield Named a Fellow of the American Association for the Advancement of Science
Soni Lacefield, PhD, a professor of biochemistry and cell biology at Dartmouth’s Geisel School of Medicine, has been named a 2025 Fellow of the American Association for the Advancement of Science (…
geiselmed.dartmouth.edu
March 29, 2025 at 12:40 AM
Super excited that my superstar friend Soni Lacefield @lacefieldlab.bsky.social is a AAAS fellow! See how her creative research is making an impact on our understanding of meiosis and infertility.
geiselmed.dartmouth.edu/news/2025/so...
geiselmed.dartmouth.edu/news/2025/so...
Reposted by Soni Lacefield
Congratulations to @lacefieldlab.bsky.social and all the other @aaas.org Fellows! 🥳
geiselmed.dartmouth.edu/news/2025/so...
geiselmed.dartmouth.edu/news/2025/so...
Soni Lacefield Named a Fellow of the American Association for the Advancement of Science
Soni Lacefield, PhD, a professor of biochemistry and cell biology at Dartmouth’s Geisel School of Medicine, has been named a 2025 Fellow of the American Association for the Advancement of Science (…
geiselmed.dartmouth.edu
March 28, 2025 at 6:15 PM
Congratulations to @lacefieldlab.bsky.social and all the other @aaas.org Fellows! 🥳
geiselmed.dartmouth.edu/news/2025/so...
geiselmed.dartmouth.edu/news/2025/so...
Reposted by Soni Lacefield
Happy birthday to Canadian medical researcher & #biochemist Maud Menten (1879-1960). 🧪🐡👩🏼🔬 #histscj Not only was she an author of Michaelis-Menten equation for enzyme kinetics, she invented the azo-dye coupling for alkaline phosphatase, 1st example of enzyme histochemistry, still used in imaging of 🧵
March 20, 2025 at 11:46 AM
Happy birthday to Canadian medical researcher & #biochemist Maud Menten (1879-1960). 🧪🐡👩🏼🔬 #histscj Not only was she an author of Michaelis-Menten equation for enzyme kinetics, she invented the azo-dye coupling for alkaline phosphatase, 1st example of enzyme histochemistry, still used in imaging of 🧵
Reposted by Soni Lacefield
Some good news during these difficult times. Please check out our new preprint. We built a new tool to probe the origins of high oocyte aneuploidy rates at advanced female reproductive ages. This NIH funded work was led by a fantastic postdoc in the lab, Jiyeon Leem. www.biorxiv.org/content/10.1...
A versatile cohesion manipulation system reveals CENP-A dysfunction accelerates female reproductive age-related egg aneuploidy.
Female reproductive aging is accompanied by a dramatic rise in the incidence of egg aneuploidy. Premature loss of chromosome cohesion proteins and untimely separation of chromosomes is thought to unde...
www.biorxiv.org
February 28, 2025 at 12:39 PM
Some good news during these difficult times. Please check out our new preprint. We built a new tool to probe the origins of high oocyte aneuploidy rates at advanced female reproductive ages. This NIH funded work was led by a fantastic postdoc in the lab, Jiyeon Leem. www.biorxiv.org/content/10.1...