LabSoap
@labsoap.bsky.social
S.O.A.P. Team in Nantes, France
Led by Julie Gavard & Nicolas Bidere
Signaling in Oncogenesis, Angiogenesis, and Permeability
#glioblastoma #cancer #research
Led by Julie Gavard & Nicolas Bidere
Signaling in Oncogenesis, Angiogenesis, and Permeability
#glioblastoma #cancer #research
Pinned
LabSoap
@labsoap.bsky.social
· May 12
Important Fact: Higher Education and Research is the place where LGBTI+phobic assaults are most common.
What can we do?
- Continue to stay informed and educated
- Include and make LGBTI+ people visible
- Reject harmful behaviors
Here is our SOAPainbow 🌈
What can we do?
- Continue to stay informed and educated
- Include and make LGBTI+ people visible
- Reject harmful behaviors
Here is our SOAPainbow 🌈
This week #JournalClub @labsoap.bsky.social @science.org #LYVAC #vacuole #lysosome www.science.org/doi/10.1126/...
LYVAC/PDZD8 is a lysosomal vacuolator
Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anch...
www.science.org
November 10, 2025 at 4:54 PM
@labsoap.bsky.social back from #Turku #0carbon #greencity #Finland for a very neat and excellent meeting on #braintumor #glioblastoma @fibtra.bsky.social
October 30, 2025 at 9:52 AM
@labsoap.bsky.social back from #Turku #0carbon #greencity #Finland for a very neat and excellent meeting on #braintumor #glioblastoma @fibtra.bsky.social
This week #JournalClub @labsoap.bsky.social www.science.org/doi/10.1126/... #inflammation #STING #sensing @science.org
MTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonists
Cytosolic nucleic acid–sensing pathways are potential targets for cancer immunotherapy. Although stimulator of interferon genes (STING) agonists have shown substantial antitumor effects in animal mode...
www.science.org
October 29, 2025 at 2:48 PM
This week #JournalClub @labsoap.bsky.social #DNArepair #cGAS #STING @science.org #molerat 🐀 www.science.org/doi/10.1126/...
October 20, 2025 at 2:42 PM
This week #journalclub @labsoap.bsky.social @naturemetabolism.bsky.social @agostinislab.bsky.social #Lysosome #ferroptosis #mitochondria www.nature.com/articles/s42...
Client Challenge
www.nature.com
October 13, 2025 at 4:16 PM
This week #JournalClub @labsoap.bsky.social #Immunotherapy #resistance #cancerneuroscience @nature.com www.nature.com/articles/s41...
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy - Nature
Perineural invasion and cancer-induced nerve injury of tumour-associated nerves are associated with poor response to anti-PD-1 therapy, which can be reversed by combining anti-PD-1 therapy with anti-inflammatory interventions.
www.nature.com
September 29, 2025 at 7:41 AM
This week #JournalClub @labsoap.bsky.social @nature.com #glioblastoma #injury #neuroscience #initiation #progression www.nature.com/articles/s41...
Axonal injury is a targetable driver of glioblastoma progression - Nature
Axonal injury, induced in the white matter by expansion of early tumour cells, is a key driver of glioblastoma progression.
www.nature.com
September 15, 2025 at 7:55 AM
Reposted by LabSoap
Editor's selected articles of the last two years onlinelibrary.wiley.com/doi/toc/10.1...
Editors Choice Articles: Traffic
Traffic is a cell biology and biochemistry journal devoted to intracellular transport, covering subcellular trafficking, membrane dynamics, organelle function & more.
onlinelibrary.wiley.com
September 3, 2025 at 7:11 AM
Editor's selected articles of the last two years onlinelibrary.wiley.com/doi/toc/10.1...
This week #JournalClub @labsoap.bsky.social #mitophagy #differentiation #stemness #cancer @nature.com www.nature.com/articles/s41...
DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species - Nature Communications
Cancer stem-like cells contribute to tumor growth and therapy resistance in glioblastoma. Here, authors identify that DHRS13 inhibition promotes differentiation of glioma stem-like cells by activating...
www.nature.com
September 1, 2025 at 7:03 PM
Reposted by LabSoap
#ResultatScientifique 🔎 | Glioblastome : la molécule JAMC agit comme un “frein” naturel, limitant la migration des cellules souches tumorales dans le cerveau. 🧠
✍️ Julie GAVARD
📕 @cp-cellreports.bsky.social | buff.ly/CKaIOu9
✍️ Julie GAVARD
📕 @cp-cellreports.bsky.social | buff.ly/CKaIOu9
August 27, 2025 at 3:04 PM
#ResultatScientifique 🔎 | Glioblastome : la molécule JAMC agit comme un “frein” naturel, limitant la migration des cellules souches tumorales dans le cerveau. 🧠
✍️ Julie GAVARD
📕 @cp-cellreports.bsky.social | buff.ly/CKaIOu9
✍️ Julie GAVARD
📕 @cp-cellreports.bsky.social | buff.ly/CKaIOu9
🧠🔬Targeting #celladhesion #JAMC to limit #glioblastoma #stemcell #invasion
📄 @cellpress.bsky.social www.sciencedirect.com/science/arti...
🙏 co-authors and support @cnrsbiologie.bsky.social @insermgrandouest.bsky.social #Nantes #Angers Universities #LigueContreCancer @fondationarc.bsky.social #INCA
📄 @cellpress.bsky.social www.sciencedirect.com/science/arti...
🙏 co-authors and support @cnrsbiologie.bsky.social @insermgrandouest.bsky.social #Nantes #Angers Universities #LigueContreCancer @fondationarc.bsky.social #INCA
August 27, 2025 at 12:25 PM
🧠🔬Targeting #celladhesion #JAMC to limit #glioblastoma #stemcell #invasion
📄 @cellpress.bsky.social www.sciencedirect.com/science/arti...
🙏 co-authors and support @cnrsbiologie.bsky.social @insermgrandouest.bsky.social #Nantes #Angers Universities #LigueContreCancer @fondationarc.bsky.social #INCA
📄 @cellpress.bsky.social www.sciencedirect.com/science/arti...
🙏 co-authors and support @cnrsbiologie.bsky.social @insermgrandouest.bsky.social #Nantes #Angers Universities #LigueContreCancer @fondationarc.bsky.social #INCA
This week #JournalClub @LabSoap #nuclear #autophagy #inflammation @nature.com www.nature.com/articles/s41...
WSTF nuclear autophagy regulates chronic but not acute inflammation - Nature
During chronic but not acute inflammation, chromatin remodelling is influenced by nuclear autophagy through WSTF interaction with ATG8 in the nucleus, leading to WSTF nuclear export and its subsequent...
www.nature.com
July 7, 2025 at 11:08 AM
This week #JournalClub @LabSoap #nuclear #autophagy #inflammation @nature.com www.nature.com/articles/s41...
This week #JournalClub @LabSoap @cellpress.bsky.social #CGAS #DNAamplification #virus www.cell.com/cell/abstrac...
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification
and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune
surveillance mechanism in the nu...
www.cell.com
July 1, 2025 at 9:12 PM
This week #JournalClub @LabSoap @cellpress.bsky.social #CGAS #DNAamplification #virus www.cell.com/cell/abstrac...
This week #JournalClub @labsoap.bsky.social #celldeath #RedBloodCell #Inflammasome @cellpress.bsky.social www.cell.com/cell/abstrac...
Red blood cells undergo lytic programmed cell death involving NLRP3
Complement exposure induces programmed cell death of red blood cells due to the intracellular
activation of miniNLRP3 and caspase-8. Inhibiting NLRP3 signaling reduces cytoskeletal
damage and prevents...
www.cell.com
June 23, 2025 at 7:59 PM
This week #JournalClub @labsoap.bsky.social #LAG3 #immunecheckpoint @cellpress.bsky.social www.cell.com/cell/fulltex...
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs
This study uncovers the molecular mechanism of LAG3 activation upon ligand engagement
and its regulation by non-degradative polyubiquitination within the tumor microenvironment.
The findings highlight...
www.cell.com
June 16, 2025 at 2:54 PM
This week #JournalClub @labsoap.bsky.social @natcancer.nature.com #glioblastoma #Plexin #infiltration www.nature.com/articles/s43...
Glioblastoma shift from bulk to infiltrative growth is guided by plexin-B2-mediated microglia alignment in invasive niches - Nature Cancer
Kang et al. define distinct spatial niches within glioblastoma (GBM) tumors according to their infiltrative nature and report that glioma cells induce microglia and macrophage alignments through plexi...
www.nature.com
June 10, 2025 at 7:18 PM
Reposted by LabSoap
Important Fact: Higher Education and Research is the place where LGBTI+phobic assaults are most common.
What can we do?
- Continue to stay informed and educated
- Include and make LGBTI+ people visible
- Reject harmful behaviors
Here is our SOAPainbow 🌈
What can we do?
- Continue to stay informed and educated
- Include and make LGBTI+ people visible
- Reject harmful behaviors
Here is our SOAPainbow 🌈
May 12, 2025 at 10:36 AM
Important Fact: Higher Education and Research is the place where LGBTI+phobic assaults are most common.
What can we do?
- Continue to stay informed and educated
- Include and make LGBTI+ people visible
- Reject harmful behaviors
Here is our SOAPainbow 🌈
What can we do?
- Continue to stay informed and educated
- Include and make LGBTI+ people visible
- Reject harmful behaviors
Here is our SOAPainbow 🌈
This week #JournalClub @labsoap.bsky.social @science.org #Nemo #IKK #DDR www.science.org/doi/10.1126/...
NEMO is essential for directing the kinases IKKα and ATM to the sites of DNA damage
The protein NEMO coordinates the recognition of DNA damage to initiate repair.
www.science.org
June 2, 2025 at 11:12 AM
Excellent science and friendly atmosphere at the #JSNU2025 #glialcommunication #symposium And great talks from @laisbfugio.bsky.social #quentinroux 🤩
May 28, 2025 at 6:18 AM
Excellent science and friendly atmosphere at the #JSNU2025 #glialcommunication #symposium And great talks from @laisbfugio.bsky.social #quentinroux 🤩
This week #JournalClub #ferroptosis #iron #lysosome @nature.com @institutcurie.bsky.social www.nature.com/articles/s41...
Activation of lysosomal iron triggers ferroptosis in cancer - Nature
Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.
www.nature.com
May 26, 2025 at 4:50 PM
This week #JournalClub @labsoap.bsky.social #mitochondria #inflammation #tumor @nature.com www.nature.com/articles/s41...
VDAC2 loss elicits tumour destruction and inflammation for cancer therapy - Nature
VDAC2 deficiency elicits uncontrolled IFNγ-induced BAK activation and mitochondrial damage for improved cancer therapy.
www.nature.com
May 19, 2025 at 9:25 PM
This week #JournalClub @labsoap.bsky.social @nature.com @taijamakinenlab.bsky.social #lymphatics #cellshape
#cytoskeleton
www.nature.com/articles/s41...
#cytoskeleton
www.nature.com/articles/s41...
Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium - Nature
Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous...
www.nature.com
May 12, 2025 at 5:17 PM
Important Fact: Higher Education and Research is the place where LGBTI+phobic assaults are most common.
What can we do?
- Continue to stay informed and educated
- Include and make LGBTI+ people visible
- Reject harmful behaviors
Here is our SOAPainbow 🌈
What can we do?
- Continue to stay informed and educated
- Include and make LGBTI+ people visible
- Reject harmful behaviors
Here is our SOAPainbow 🌈
May 12, 2025 at 10:36 AM
Important Fact: Higher Education and Research is the place where LGBTI+phobic assaults are most common.
What can we do?
- Continue to stay informed and educated
- Include and make LGBTI+ people visible
- Reject harmful behaviors
Here is our SOAPainbow 🌈
What can we do?
- Continue to stay informed and educated
- Include and make LGBTI+ people visible
- Reject harmful behaviors
Here is our SOAPainbow 🌈