Kyle Card
@kylejcard.bsky.social
HHMI Hanna Gray Fellow at the Cleveland Clinic studying drug resistance evolution w/ Jacob Scott 💊 | HHMI Gilliam Fellow & Ph.D. w/ Richard Lenski | #DisabledInSTEM 🦾 | He/Him
I would also like to thank the reviewers for their thoughtful, positive, and constructive feedback!
September 27, 2025 at 5:45 PM
I would also like to thank the reviewers for their thoughtful, positive, and constructive feedback!
It was a pleasure working with this talented, multidisciplinary team: Dena Crozier, Arda Durmaz, Jason Gray, Justin Creary, Amira Stocks, @jeffmaltas.bsky.social, Robert Bonomo, Zachary Burke, and Jacob Scott.
👉 Paper link: www.pnas.org/doi/10.1073/...
5/5
👉 Paper link: www.pnas.org/doi/10.1073/...
5/5
Evolution under vancomycin selection drives divergent collateral sensitivity patterns in Staphylococcus aureus | PNAS
Staphylococcus aureus bacteremia is typically treated empirically with vancomycin,
with therapy later tailored based on susceptibility results. How...
www.pnas.org
September 27, 2025 at 5:40 PM
It was a pleasure working with this talented, multidisciplinary team: Dena Crozier, Arda Durmaz, Jason Gray, Justin Creary, Amira Stocks, @jeffmaltas.bsky.social, Robert Bonomo, Zachary Burke, and Jacob Scott.
👉 Paper link: www.pnas.org/doi/10.1073/...
5/5
👉 Paper link: www.pnas.org/doi/10.1073/...
5/5
The big idea: antibiotic stewardship isn’t just about “what works now,” but also about anticipating where evolution is going next.
4/5
4/5
September 27, 2025 at 5:36 PM
The big idea: antibiotic stewardship isn’t just about “what works now,” but also about anticipating where evolution is going next.
4/5
4/5
To make sense of this stochasticity, we introduced the Collateral Response Score, a probabilistic framework for forecasting how prior treatment history shapes future drug options.
3/5
3/5
September 27, 2025 at 5:35 PM
To make sense of this stochasticity, we introduced the Collateral Response Score, a probabilistic framework for forecasting how prior treatment history shapes future drug options.
3/5
3/5
The answer: evolution doesn’t just increase vancomycin resistance — it reshapes the bacterium’s response to the very drugs we’d normally switch to next. Some lineages become collaterally sensitive, while others become collaterally resistant, depending on the evolutionary path they take.
2/5
2/5
September 27, 2025 at 5:33 PM
The answer: evolution doesn’t just increase vancomycin resistance — it reshapes the bacterium’s response to the very drugs we’d normally switch to next. Some lineages become collaterally sensitive, while others become collaterally resistant, depending on the evolutionary path they take.
2/5
2/5
Happy birthday to the LTEE! 🎉
February 24, 2025 at 7:15 PM
Happy birthday to the LTEE! 🎉
Hey! I'm a disabled microbiologist and evolutionary biologist who is missing fingers on both hands. I've been doing research at the bench for over a decade.
It's definitely possible 🙂
It's definitely possible 🙂
February 23, 2025 at 5:28 AM
Hey! I'm a disabled microbiologist and evolutionary biologist who is missing fingers on both hands. I've been doing research at the bench for over a decade.
It's definitely possible 🙂
It's definitely possible 🙂