@ktr-nakanishi.bsky.social
Professor / PI of the Nakanishi Lab https://u.osu.edu/nakanishilab/)/ I study tinyRNAs, cityRNAs and other small noncoding RNAs. https://twitter.com/ktr_nakanishi
Reposted
One of the most-viewed PNAS articles in the last week is “Neurodevelopmental disorder–linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3′→5′ trimming.” Explore now: https://ow.ly/hwP450XxHM6
For more trending articles, visit https://ow.ly/q6Cl50XxHGN.
For more trending articles, visit https://ow.ly/q6Cl50XxHGN.
November 25, 2025 at 10:00 PM
One of the most-viewed PNAS articles in the last week is “Neurodevelopmental disorder–linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3′→5′ trimming.” Explore now: https://ow.ly/hwP450XxHM6
For more trending articles, visit https://ow.ly/q6Cl50XxHGN.
For more trending articles, visit https://ow.ly/q6Cl50XxHGN.
Just published! AGO syndrome mutants slow passenger ejection, leaving the guide’s 3′ end exposed to 3′→5′ exonucleases that generate tyRNAs. This atypical trimming may occur during periods of stress or viral infection, potentially leading to neurodevelopmental disorders.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Neurodevelopmental disorder–linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3′→5′ trimming | PNAS
Mutations in Argonaute proteins (AGOs) cause Argonaute syndrome, a neurodevelopmental
disorder (NDD), yet the underlying molecular mechanism remain...
www.pnas.org
November 14, 2025 at 7:20 PM
Just published! AGO syndrome mutants slow passenger ejection, leaving the guide’s 3′ end exposed to 3′→5′ exonucleases that generate tyRNAs. This atypical trimming may occur during periods of stress or viral infection, potentially leading to neurodevelopmental disorders.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted
Regulated decay of microRNAs plays a critical role in controlling body size in mammals! Check out our new paper in @genesdev.bsky.social and see thread previously posted with our pre-print 👇 for more info. Congrats to Collette LaVigne, Jaeil Han, and all authors!
genesdev.cshlp.org/cgi/content/...
genesdev.cshlp.org/cgi/content/...
November 10, 2025 at 5:40 PM
Regulated decay of microRNAs plays a critical role in controlling body size in mammals! Check out our new paper in @genesdev.bsky.social and see thread previously posted with our pre-print 👇 for more info. Congrats to Collette LaVigne, Jaeil Han, and all authors!
genesdev.cshlp.org/cgi/content/...
genesdev.cshlp.org/cgi/content/...
Reposted
Excited to announce the submission of our CTA to the @mhragovuk.bsky.social to initiate a Phase 1 study of CITY-FXI, an investigational RNAi therapeutic targeting Factor XI w/ the potential to safely & effectively prevent blood clots without increasing bleeding risk. www.citytx.com/news/city-th...
November 10, 2025 at 1:08 PM
Excited to announce the submission of our CTA to the @mhragovuk.bsky.social to initiate a Phase 1 study of CITY-FXI, an investigational RNAi therapeutic targeting Factor XI w/ the potential to safely & effectively prevent blood clots without increasing bleeding risk. www.citytx.com/news/city-th...
Reposted
Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)
mRNA 3′ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth
MicroRNAs direct downregulation of target mRNAs. Sometimes, however, this regulatory paradigm inverts, and a target RNA triggers the degradation of a microRNA. This target-directed microRNA degradatio...
www.biorxiv.org
November 7, 2025 at 6:33 PM
Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)
Jacob Schwartz received an outstanding poster award at the Rustbelt RNA Meeting 2025🎉 Congrats👏👏👏
October 25, 2025 at 10:53 PM
Jacob Schwartz received an outstanding poster award at the Rustbelt RNA Meeting 2025🎉 Congrats👏👏👏
It’s nice to see Nature Biotech’s article featuring CityTX and my work!
www.nature.com/articles/s41...
* Phil is Yuki Tomari’s advisor, not mine. I had my postdoc training under Dinshaw Patel (MSKCC).
www.nature.com/articles/s41...
* Phil is Yuki Tomari’s advisor, not mine. I had my postdoc training under Dinshaw Patel (MSKCC).
Editor’s Pick: City Therapeutics - Nature Biotechnology
Each year, Nature Biotechnology highlights companies that received sizeable early-stage funding in the previous year. City Therapeutics is using very small cityRNAs to broaden the range of siRNA thera...
www.nature.com
September 18, 2025 at 10:55 AM
It’s nice to see Nature Biotech’s article featuring CityTX and my work!
www.nature.com/articles/s41...
* Phil is Yuki Tomari’s advisor, not mine. I had my postdoc training under Dinshaw Patel (MSKCC).
www.nature.com/articles/s41...
* Phil is Yuki Tomari’s advisor, not mine. I had my postdoc training under Dinshaw Patel (MSKCC).
Reposted
Today’s MLS Seminar
Dr. Phil Zamore, Howard Hughes Medical Institute
4:10 — 5:05PM
DHLRI 170
Dr. Phil Zamore, Howard Hughes Medical Institute
4:10 — 5:05PM
DHLRI 170
September 16, 2025 at 12:23 PM
Today’s MLS Seminar
Dr. Phil Zamore, Howard Hughes Medical Institute
4:10 — 5:05PM
DHLRI 170
Dr. Phil Zamore, Howard Hughes Medical Institute
4:10 — 5:05PM
DHLRI 170
Reposted
Argonaute conference #Argonaute2025 in Prague – researchers, clinicians & patient families coming together. Honored to co-organize this fantastic, inspiring meeting with amazing colleagues @svobodalab.bsky.social, @farmgirlphd.bsky.social & @curiousdina.bsky.social
September 8, 2025 at 12:36 PM
Argonaute conference #Argonaute2025 in Prague – researchers, clinicians & patient families coming together. Honored to co-organize this fantastic, inspiring meeting with amazing colleagues @svobodalab.bsky.social, @farmgirlphd.bsky.social & @curiousdina.bsky.social
Reposted
in these mostly wretched times, you have to find joy wherever you can. last week my ad hoc band the Argonautes (me, Yuki Tomari, Germano Cecere) had a blast playing in Prague. we rocked some old and new songs, and can't wait to do it again in Toronto 2027!
September 7, 2025 at 8:54 PM
in these mostly wretched times, you have to find joy wherever you can. last week my ad hoc band the Argonautes (me, Yuki Tomari, Germano Cecere) had a blast playing in Prague. we rocked some old and new songs, and can't wait to do it again in Toronto 2027!
Reposted
Kicking off our third day of #argonautes2025 with a talk by Nobel Prize winner and all around amazing person, scientist, and mentor, Victor Ambros! 🐙
August 29, 2025 at 7:07 AM
Kicking off our third day of #argonautes2025 with a talk by Nobel Prize winner and all around amazing person, scientist, and mentor, Victor Ambros! 🐙
Reposted
The Argonautes 2025 - we made a special gift for participants - a card set with 32 different Argonautes + an extension pack with four Nobel prize winners from the small RNA field. Mello, Fire, Ambros & Ruvkun as jokers :-) #argonautes2025
August 28, 2025 at 3:01 PM
The Argonautes 2025 - we made a special gift for participants - a card set with 32 different Argonautes + an extension pack with four Nobel prize winners from the small RNA field. Mello, Fire, Ambros & Ruvkun as jokers :-) #argonautes2025
I will speak about “𝗚𝗲𝗻𝗲 𝗦𝗶𝗹𝗲𝗻𝗰𝗶𝗻𝗴 𝗯𝘆 𝗰𝗶𝘁𝘆𝗥𝗡𝗔𝘀" at RNA Collaborative on 𝗦𝗲𝗽𝘁. 𝟭𝟬𝘁𝗵!
Zoom Registration:https://us02web.zoom.us/webinar/register/WN_G5a1Vp9oTvmF2NWKmdAGxw#/registration
Zoom Registration:https://us02web.zoom.us/webinar/register/WN_G5a1Vp9oTvmF2NWKmdAGxw#/registration
August 28, 2025 at 10:54 PM
I will speak about “𝗚𝗲𝗻𝗲 𝗦𝗶𝗹𝗲𝗻𝗰𝗶𝗻𝗴 𝗯𝘆 𝗰𝗶𝘁𝘆𝗥𝗡𝗔𝘀" at RNA Collaborative on 𝗦𝗲𝗽𝘁. 𝟭𝟬𝘁𝗵!
Zoom Registration:https://us02web.zoom.us/webinar/register/WN_G5a1Vp9oTvmF2NWKmdAGxw#/registration
Zoom Registration:https://us02web.zoom.us/webinar/register/WN_G5a1Vp9oTvmF2NWKmdAGxw#/registration
Reposted
Argonautes are coming :-) ... soon at @imgprague.bsky.social ... finishing preparations. Still missing a few things like drums, guitar, badges, beer ... but it's under control. I think. I hope. :-))
#argonautes2025
#argonautes2025
August 21, 2025 at 12:48 PM
Argonautes are coming :-) ... soon at @imgprague.bsky.social ... finishing preparations. Still missing a few things like drums, guitar, badges, beer ... but it's under control. I think. I hope. :-))
#argonautes2025
#argonautes2025
Reposted
My team has updated our free database of POSTDOC fellowships.
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
August 10, 2025 at 7:50 PM
My team has updated our free database of POSTDOC fellowships.
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
Reposted
Biogen and City Therapeutics announce strategic research collaboration to develop select novel RNAi-based therapies. Congratulations to this #OhioStateStartup founded on technology developed by Kotaro Nakanishi
May 28, 2025 at 9:44 PM
Biogen and City Therapeutics announce strategic research collaboration to develop select novel RNAi-based therapies. Congratulations to this #OhioStateStartup founded on technology developed by Kotaro Nakanishi
Reposted
Exciting news from City! We’ve partnered with Biogen to develop select novel RNAi-based therapies leveraging our next-generation RNAi engineering technologies. Learn more: www.globenewswire.com/news-release...
May 27, 2025 at 11:46 AM
Exciting news from City! We’ve partnered with Biogen to develop select novel RNAi-based therapies leveraging our next-generation RNAi engineering technologies. Learn more: www.globenewswire.com/news-release...
My research group seeks a highly motivated Post-Bacc (or Tech). This position offers a unique opportunity to contribute to research on cleavage-inducing tiny RNAs (cityRNAs) to treat neurological and neuromuscular disorders, Cancer, Alzheimer's diseases, etc.
u.osu.edu/cbcundergrad...
u.osu.edu/cbcundergrad...
Job Opportunity for Recent Graduates (Post-Bacc) | CBC Undergraduate Program
u.osu.edu
May 6, 2025 at 12:59 PM
My research group seeks a highly motivated Post-Bacc (or Tech). This position offers a unique opportunity to contribute to research on cleavage-inducing tiny RNAs (cityRNAs) to treat neurological and neuromuscular disorders, Cancer, Alzheimer's diseases, etc.
u.osu.edu/cbcundergrad...
u.osu.edu/cbcundergrad...
I'm honored that the Science Coalition highlights our research on cityRNAs as the science sparking American economic growth in 2025!
www.sciencecoalition.org/2025/04/29/s...
www.sciencecoalition.org/2025/04/29/s...
April 30, 2025 at 12:52 PM
I'm honored that the Science Coalition highlights our research on cityRNAs as the science sparking American economic growth in 2025!
www.sciencecoalition.org/2025/04/29/s...
www.sciencecoalition.org/2025/04/29/s...
Tulip festival in Ohio.
April 21, 2025 at 1:25 AM
Tulip festival in Ohio.
Reposted
Argonautes 2025 will cover progress in:
Structural insights
Effector complexes: formation, composition & function
Post-transcriptional silencing
Transcriptional silencing & DNA cleavage
Post-translational modifications and regulations
Medical aspects
27-30/8/2025
argonautes.img.cas.cz
Pls RT!
Structural insights
Effector complexes: formation, composition & function
Post-transcriptional silencing
Transcriptional silencing & DNA cleavage
Post-translational modifications and regulations
Medical aspects
27-30/8/2025
argonautes.img.cas.cz
Pls RT!
April 4, 2025 at 12:55 AM
Argonautes 2025 will cover progress in:
Structural insights
Effector complexes: formation, composition & function
Post-transcriptional silencing
Transcriptional silencing & DNA cleavage
Post-translational modifications and regulations
Medical aspects
27-30/8/2025
argonautes.img.cas.cz
Pls RT!
Structural insights
Effector complexes: formation, composition & function
Post-transcriptional silencing
Transcriptional silencing & DNA cleavage
Post-translational modifications and regulations
Medical aspects
27-30/8/2025
argonautes.img.cas.cz
Pls RT!
Reposted
Why NIH/NIGMS funding of basic research matters with our latest work now out in @cp-cellreports.bsky.social sky.social. We solved a >30-year-old mystery of what transcription factor drives the Flamenco piRNA cluster required for female Drosophila fertility. /1
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Traffic Jam activates the Flamenco piRNA cluster locus and the Piwi pathway to ensure transposon silencing and Drosophila fertility
Rivera et al. discover Drosophila Flamenco piRNA cluster enhancers bound and activated
by the Traffic Jam transcription factor. Traffic Jam also binds many follicle cell
genes including activating mul...
www.cell.com
April 11, 2025 at 4:38 PM
Why NIH/NIGMS funding of basic research matters with our latest work now out in @cp-cellreports.bsky.social sky.social. We solved a >30-year-old mystery of what transcription factor drives the Flamenco piRNA cluster required for female Drosophila fertility. /1
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted
What was that you said? You are looking for new #RNA research to read in the weekend?
You are in luck!
📣 📣 Check out the new preprint from our lab!!!! 📣 📣
www.biorxiv.org/content/10.1...
You are in luck!
📣 📣 Check out the new preprint from our lab!!!! 📣 📣
www.biorxiv.org/content/10.1...
AGO2 slicing of a domesticated retrotransposon is necessary for normal vasculature development
Argonaute (AGO) mediated slicing of RNA, also known as RNAi, is a highly conserved phenomenon that is evolutionarily linked to the repression of transposons and other repeats. Although RNAi is no long...
www.biorxiv.org
April 4, 2025 at 5:35 PM
What was that you said? You are looking for new #RNA research to read in the weekend?
You are in luck!
📣 📣 Check out the new preprint from our lab!!!! 📣 📣
www.biorxiv.org/content/10.1...
You are in luck!
📣 📣 Check out the new preprint from our lab!!!! 📣 📣
www.biorxiv.org/content/10.1...