Aswin Krishna
@krishnaaswin77.bsky.social
PhD student at ETH Zürich
Thinking about the ecology of infectious pathogens, and antibiotic resistance
Thinking about the ecology of infectious pathogens, and antibiotic resistance
Reposted by Aswin Krishna
New(ish!) paper on how within-host competition and antibiotic resistance shape the fitness of Streptococcus pneumoniae serotypes, out in August in Plos Biology. journals.plos.org/plosbiology/...
Quantifying the effects of antibiotic resistance and within-host competition on strain fitness in Streptococcus pneumoniae
Competition significantly influences bacterial population dynamics, particularly in how strains interact within and between hosts. This study shows that within-host competition in Streptococcus pneumo...
journals.plos.org
October 31, 2025 at 3:05 PM
New(ish!) paper on how within-host competition and antibiotic resistance shape the fitness of Streptococcus pneumoniae serotypes, out in August in Plos Biology. journals.plos.org/plosbiology/...
Reposted by Aswin Krishna
Competition & #bacterial #PopulationDynamics. @krishnaaswin77.bsky.social @sonjalehtinen.bsky.social &co show that within-host competition in #Streptococcus increases clearance & reduces establishment; #AntibioticResistance increases susceptibility to competition @plosbiology.org 🧪 plos.io/4lqcZba
August 7, 2025 at 8:03 AM
Competition & #bacterial #PopulationDynamics. @krishnaaswin77.bsky.social @sonjalehtinen.bsky.social &co show that within-host competition in #Streptococcus increases clearance & reduces establishment; #AntibioticResistance increases susceptibility to competition @plosbiology.org 🧪 plos.io/4lqcZba
Reposted by Aswin Krishna
Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬?
In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments!
👇 Check out all the details in Paula’s thread!
Hint: 🐇 (most of the time)
In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments!
👇 Check out all the details in Paula’s thread!
Hint: 🐇 (most of the time)
July 22, 2025 at 3:05 PM
Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬?
In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments!
👇 Check out all the details in Paula’s thread!
Hint: 🐇 (most of the time)
In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments!
👇 Check out all the details in Paula’s thread!
Hint: 🐇 (most of the time)
Two postdoc positions have been advertised in our lab at @ethzurich.bsky.social with Sebastian Bonhoeffer & Roland Regoes. If you are interested in experimental (jobs.ethz.ch/job/view/JOP...) or theoretical (jobs.ethz.ch/job/view/JOP...) epidemiology, then apply before the 2nd of June!
Postdoctoral Researcher – Experimental Microbial Population Biology
jobs.ethz.ch
May 7, 2025 at 4:04 PM
Two postdoc positions have been advertised in our lab at @ethzurich.bsky.social with Sebastian Bonhoeffer & Roland Regoes. If you are interested in experimental (jobs.ethz.ch/job/view/JOP...) or theoretical (jobs.ethz.ch/job/view/JOP...) epidemiology, then apply before the 2nd of June!
Reposted by Aswin Krishna
New paper: long-term trends in antibiotic resistance show signs of stabilisation (thread). journals.plos.org/plospathogen...
The evolution of antibiotic resistance in Europe, 1998–2019
Author summary Antibiotic resistance is an important public health threat: resistant infections are currently associated with 5 million deaths per year globally. This burden may increase further in th...
journals.plos.org
April 7, 2025 at 8:36 AM
New paper: long-term trends in antibiotic resistance show signs of stabilisation (thread). journals.plos.org/plospathogen...
Reposted by Aswin Krishna
In the fight against bacterial pathogens, researchers are combining vaccination with targeted colonization of the intestine by harmless microorganisms. This approach could potentially mark a turning point in the antibiotics crisis. www.biozentrum.unibas.ch/news/detail/...
New vaccine concept tackles harmful bacteria in the intestine
In the fight against bacterial pathogens, researchers are combining vaccination with targeted colonization of the intestine by harmless microorganisms. This approach could potentially mark a turning p...
www.biozentrum.unibas.ch
April 4, 2025 at 7:49 AM
In the fight against bacterial pathogens, researchers are combining vaccination with targeted colonization of the intestine by harmless microorganisms. This approach could potentially mark a turning point in the antibiotics crisis. www.biozentrum.unibas.ch/news/detail/...
New preprint! 📢 Using a large longitudinal dataset of bacterial carriage we ask:
(A) Does within-host competition between bacterial strains lower their epidemiological fitness?
(B) Does this strain competition affect the fitness of Abx-resistant bugs?
Answer to both = yes. More details here👇
(A) Does within-host competition between bacterial strains lower their epidemiological fitness?
(B) Does this strain competition affect the fitness of Abx-resistant bugs?
Answer to both = yes. More details here👇
Quantifying the effects of antibiotic resistance and within-host competition on strain fitness in Streptococcus pneumoniae https://www.biorxiv.org/content/10.1101/2025.03.09.642042v1
March 31, 2025 at 10:40 AM
New preprint! 📢 Using a large longitudinal dataset of bacterial carriage we ask:
(A) Does within-host competition between bacterial strains lower their epidemiological fitness?
(B) Does this strain competition affect the fitness of Abx-resistant bugs?
Answer to both = yes. More details here👇
(A) Does within-host competition between bacterial strains lower their epidemiological fitness?
(B) Does this strain competition affect the fitness of Abx-resistant bugs?
Answer to both = yes. More details here👇
Reposted by Aswin Krishna
🚨 New preprint!! How can antibiotic-resistant bacteria increase in abundance in the human gut microbiome, even without antibiotics? 🧐 We show that strain-specific ecological interactions are key to understanding resistance dynamics in microbial communities. 🧵👇 1/5
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
December 11, 2024 at 12:30 PM
🚨 New preprint!! How can antibiotic-resistant bacteria increase in abundance in the human gut microbiome, even without antibiotics? 🧐 We show that strain-specific ecological interactions are key to understanding resistance dynamics in microbial communities. 🧵👇 1/5
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Interesting perspective to say that probability may not exist. What I make of this is - any probability value is based on an underlying model, and all models have assumptions behind them. In that sense, probabilities are subjective estimates.
An essay in Nature discusses how it’s an astonishing achievement that all of statistics and much of science depends on probability considering no one’s sure what it is. 🧪
Why probability probably doesn’t exist (but it is useful to act like it does)
All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.
go.nature.com
December 21, 2024 at 10:32 PM
Interesting perspective to say that probability may not exist. What I make of this is - any probability value is based on an underlying model, and all models have assumptions behind them. In that sense, probabilities are subjective estimates.
Really happy to see this paper out. Extra special for me because it marks my first research publication. Aswin has officially entered the academic world! 📈🦠🧑💻
What does it really mean to be in nutrient colimitation? We demonstrate a distinct growth phenotype and that (co)limitation can (and should!) be quantified. The result of many late afternoon chats with @michaelmanhart.bsky.social. Let us know what you think! www.pnas.org/doi/10.1073/pnas.2400304121
www.pnas.org
December 19, 2024 at 2:35 PM
Really happy to see this paper out. Extra special for me because it marks my first research publication. Aswin has officially entered the academic world! 📈🦠🧑💻
Reposted by Aswin Krishna
New paper from our group in @pnas.org!! 🚀
Malte Mütter used our amazing liquid-handling robot to test different treatment strategies and found that combination therapy is the most effective to prevent the emergence of plasmid-mediated double resistance www.pnas.org/doi/10.1073/...
Malte Mütter used our amazing liquid-handling robot to test different treatment strategies and found that combination therapy is the most effective to prevent the emergence of plasmid-mediated double resistance www.pnas.org/doi/10.1073/...
The impact of treatment strategies on the epidemiological dynamics of plasmid-conferred antibiotic resistance | PNAS
The issue of antibiotic resistance is a critical concern for public health, prompting
numerous investigations into the impact of treatment strategi...
www.pnas.org
December 18, 2024 at 4:08 PM
New paper from our group in @pnas.org!! 🚀
Malte Mütter used our amazing liquid-handling robot to test different treatment strategies and found that combination therapy is the most effective to prevent the emergence of plasmid-mediated double resistance www.pnas.org/doi/10.1073/...
Malte Mütter used our amazing liquid-handling robot to test different treatment strategies and found that combination therapy is the most effective to prevent the emergence of plasmid-mediated double resistance www.pnas.org/doi/10.1073/...
Cool paper on the effect of biotic interactions on the success of resistant strains within host!
🚨 New preprint!! How can antibiotic-resistant bacteria increase in abundance in the human gut microbiome, even without antibiotics? 🧐 We show that strain-specific ecological interactions are key to understanding resistance dynamics in microbial communities. 🧵👇 1/5
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
December 11, 2024 at 12:33 PM
Cool paper on the effect of biotic interactions on the success of resistant strains within host!
Reposted by Aswin Krishna
Fun to write this review with some research friends on modelling for infection disease control. Three case studies (antigen dynamics, AMR and vaccine design) and some reflections on COVID-19
www.life-science-alliance.org/content/7/9/...
www.life-science-alliance.org/content/7/9/...
Recent approaches in computational modelling for controlling pathogen threats
In this review, we assess the status of computational modelling of pathogens. We focus on three disparate but interlinked research areas that produce models with very different spatial and temporal sc...
www.life-science-alliance.org
July 2, 2024 at 12:48 PM
Fun to write this review with some research friends on modelling for infection disease control. Three case studies (antigen dynamics, AMR and vaccine design) and some reflections on COVID-19
www.life-science-alliance.org/content/7/9/...
www.life-science-alliance.org/content/7/9/...