Bjørt K.Kragesteen
@kragesteen-lab.bsky.social
Assistant professor at Karolinska Institutet. Interested in dissecting gene regulatory dynamics in development, evolution and disease
Reposted by Bjørt K.Kragesteen
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
Reposted by Bjørt K.Kragesteen
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Spatial dynamics of brain development and neuroinflammation - Nature
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
www.nature.com
November 5, 2025 at 4:03 PM
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Bjørt K.Kragesteen
Our publication is out today!Big Thanks go to my amazing collaborators: @sedonamurphy.bsky.social for her imaging brilliance and @mattjones.bsky.social for his computational support.They both saw the potential in this project and helped me to explore what turned out to be an exciting discovery.
Here, we show that the unique regulatory landscape of ecDNA enables an ancient LINE to resurrect and act as an enhancer of Myc. This was so fun with @katerinakraft.bsky.social and @mattjones.bsky.social and others. www.nature.com/articles/s41...
Enhancer activation from transposable elements in extrachromosomal DNA - Nature Cell Biology
Kraft, Murphy, Jones et al. identify extrachromosomal DNA (ecDNA)-interacting elements (EIEs) enriched for transposable elements within ecDNA in colorectal cancer cells. They show that EIE 14 integrat...
www.nature.com
October 21, 2025 at 1:34 PM
Our publication is out today!Big Thanks go to my amazing collaborators: @sedonamurphy.bsky.social for her imaging brilliance and @mattjones.bsky.social for his computational support.They both saw the potential in this project and helped me to explore what turned out to be an exciting discovery.
Reposted by Bjørt K.Kragesteen
📣 I am excited to announce that I have joined the MBB department at Karolinska Institutet in Stockholm as an assistant professor.
See below for more details!
#wearehiring
See below for more details!
#wearehiring
October 21, 2025 at 4:24 PM
📣 I am excited to announce that I have joined the MBB department at Karolinska Institutet in Stockholm as an assistant professor.
See below for more details!
#wearehiring
See below for more details!
#wearehiring
Reposted by Bjørt K.Kragesteen
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 16, 2025 at 3:06 PM
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Reposted by Bjørt K.Kragesteen
2nd Meeting on Early Embryogenesis and Epigenetics
16 - 18 Feb 2026 at MPI for Molecular Genetics, Berlin
with support by the Weizmann Institute for Science.
Early bird registration until 30 Sep - register now👇
www.molgen.mpg.de/embryo2026
16 - 18 Feb 2026 at MPI for Molecular Genetics, Berlin
with support by the Weizmann Institute for Science.
Early bird registration until 30 Sep - register now👇
www.molgen.mpg.de/embryo2026
September 26, 2025 at 1:09 PM
2nd Meeting on Early Embryogenesis and Epigenetics
16 - 18 Feb 2026 at MPI for Molecular Genetics, Berlin
with support by the Weizmann Institute for Science.
Early bird registration until 30 Sep - register now👇
www.molgen.mpg.de/embryo2026
16 - 18 Feb 2026 at MPI for Molecular Genetics, Berlin
with support by the Weizmann Institute for Science.
Early bird registration until 30 Sep - register now👇
www.molgen.mpg.de/embryo2026
Reposted by Bjørt K.Kragesteen
Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...
August 18, 2025 at 7:45 AM
Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...
Reposted by Bjørt K.Kragesteen
A little over two weeks to the deadline! 20 positions, generous startup funding, a great community and fantastic infrastructure. Come join us!
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
August 15, 2025 at 9:23 PM
A little over two weeks to the deadline! 20 positions, generous startup funding, a great community and fantastic infrastructure. Come join us!
Reposted by Bjørt K.Kragesteen
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 2, 2025 at 4:17 PM
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Reposted by Bjørt K.Kragesteen
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
June 25, 2025 at 10:08 AM
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
Reposted by Bjørt K.Kragesteen
Postdoc🚨!
Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro
Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro
Wissenschaftliche*r Mitarbeiter*in/ Postdoc (m/f/d)
Chromatin ist nicht unbeweglich. Es handelt sich um ein hochdynamisches Material, dessen 3D-Struktur zentrale genomische Prozesse – von der Transkription bis zur DNA-Reparatur – steuert. Doch wie verhält sich Chromatin als Material – als Flüssigkeit, Feststoff oder viskoelastisches Gel –, um diese Funktionen in lebenden Zellen auszuführen? Ohne eine Antwort auf diese Frage können wir nicht vollständig verstehen, wie Chromatin bei Krankheiten gestört wird.
www.mdc-berlin.de
June 20, 2025 at 7:58 AM
Postdoc🚨!
Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro
Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro
Reposted by Bjørt K.Kragesteen
Postdoc recruitment! Interested in unraveling the developmental origins of deeper skin layers?
You would leverage our in utero next generation single cell lineage tracing tools (de Haan & He et al Science 2025) to investigate dermis lineages bit.ly/43OAy7S
Interested? Find me now at #2025ICDB!
You would leverage our in utero next generation single cell lineage tracing tools (de Haan & He et al Science 2025) to investigate dermis lineages bit.ly/43OAy7S
Interested? Find me now at #2025ICDB!
Postdoctoral studies in methods development and next generation single cell lineage tracing of skin (scholarship)
Do you want to contribute to top quality medical research The research team A postdoctoral scholarship is available in the lab of Emma R Andersson at the Department of Cell and Molecular Biology, Karo
bit.ly
June 19, 2025 at 1:45 PM
Postdoc recruitment! Interested in unraveling the developmental origins of deeper skin layers?
You would leverage our in utero next generation single cell lineage tracing tools (de Haan & He et al Science 2025) to investigate dermis lineages bit.ly/43OAy7S
Interested? Find me now at #2025ICDB!
You would leverage our in utero next generation single cell lineage tracing tools (de Haan & He et al Science 2025) to investigate dermis lineages bit.ly/43OAy7S
Interested? Find me now at #2025ICDB!
Reposted by Bjørt K.Kragesteen
Heads-up for major new faculty search at KI — with great startup packages and a wide range of subject areas.
Save the date! On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility news.ki.se/ki-to-recruit-junior-researchers-with-a-focus-on-excellence
KI to recruit junior researchers with a focus on excellence
On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility. As one of Europe’s leading medical universities, KI offe...
news.ki.se
June 19, 2025 at 5:50 AM
Heads-up for major new faculty search at KI — with great startup packages and a wide range of subject areas.
Reposted by Bjørt K.Kragesteen
Save the date! On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility news.ki.se/ki-to-recruit-junior-researchers-with-a-focus-on-excellence
KI to recruit junior researchers with a focus on excellence
On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility. As one of Europe’s leading medical universities, KI offe...
news.ki.se
June 18, 2025 at 4:51 PM
Save the date! On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility news.ki.se/ki-to-recruit-junior-researchers-with-a-focus-on-excellence
Reposted by Bjørt K.Kragesteen
Come and join us! Start your group at Karolinska Institutet @ki.se!
Save the date! On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility news.ki.se/ki-to-recruit-junior-researchers-with-a-focus-on-excellence
KI to recruit junior researchers with a focus on excellence
On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility. As one of Europe’s leading medical universities, KI offe...
news.ki.se
June 18, 2025 at 5:19 PM
Come and join us! Start your group at Karolinska Institutet @ki.se!
Reposted by Bjørt K.Kragesteen
Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...
Postdoc in Single Cell Genomics, Jens Hjerling-Leffler group, Karolinska Institutet
Do you want to contribute to top quality medical research? The position is located within The Division of Molecular Neurobiology in the lab of Professor Jens Hjerling-Leffler at the Department of Medi
ki.varbi.com
June 2, 2025 at 5:20 PM
Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...
Reposted by Bjørt K.Kragesteen
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Conservation of regulatory elements with highly diverged sequences across large evolutionary distances
Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...
rdcu.be
May 27, 2025 at 12:19 PM
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Reposted by Bjørt K.Kragesteen
Night science is improvisations, openness, import/export, puzzle switching, hypothesis liabilities, anthropomorphisms, finding questions, contradictions & awe in science; as we discussed in the legendary Karolinska Institute. 🙏 @kragesteen-lab.bsky.social Christoph Ziegenhain & Rickard Sandberg
May 16, 2025 at 8:05 AM
Night science is improvisations, openness, import/export, puzzle switching, hypothesis liabilities, anthropomorphisms, finding questions, contradictions & awe in science; as we discussed in the legendary Karolinska Institute. 🙏 @kragesteen-lab.bsky.social Christoph Ziegenhain & Rickard Sandberg
Reposted by Bjørt K.Kragesteen
Full house at the Nobel Forum as @kragesteen-lab.bsky.social kicks off MBB’s new lecture series celebrating 1982 Nobel Prize winners Sune Bergström and Bengt Samuelsson. And @itaiyanai.bsky.social’s inaugural keynote lecture was as inspiring and entertaining as you’d expect! 🤩
May 14, 2025 at 8:59 PM
Full house at the Nobel Forum as @kragesteen-lab.bsky.social kicks off MBB’s new lecture series celebrating 1982 Nobel Prize winners Sune Bergström and Bengt Samuelsson. And @itaiyanai.bsky.social’s inaugural keynote lecture was as inspiring and entertaining as you’d expect! 🤩
Reposted by Bjørt K.Kragesteen
Hot off the press! 🧬🔬
We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ:
doi.org/10.1126/scie...
We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ:
doi.org/10.1126/scie...
Ectoderm barcoding reveals neural and cochlear compartmentalization
Placodes and the neural crest are defining features of vertebrates. In this study, we investigate their lineages in mice using in utero approaches. We demonstrated that nanoinjection at embryonic day ...
doi.org
April 4, 2025 at 6:24 AM
Hot off the press! 🧬🔬
We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ:
doi.org/10.1126/scie...
We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ:
doi.org/10.1126/scie...
Reposted by Bjørt K.Kragesteen
Are you an established (”distinguished”) researcher outside Europe? Thinking of moving here for some reason? Grant opportunity just dropped: www.vr.se/english/appl...
Grant for recruiting international visiting researcher to Sweden
The purpose of the grant is to provide higher education institutions and other research organisations the opportunity to develop and strengthen a research field by recruiting a distinguished researche...
www.vr.se
April 1, 2025 at 7:17 PM
Are you an established (”distinguished”) researcher outside Europe? Thinking of moving here for some reason? Grant opportunity just dropped: www.vr.se/english/appl...
Reposted by Bjørt K.Kragesteen
Israeli friends! Interested in learning & practicing the thinking tools of the creative process in science? Join the Night Science workshop in Tel Aviv University next week!
Register here: forms.office.com/r/xVhzcHTy1t
Thank you @judithberman11.bsky.social for organizing! @odedrechavi.bsky.social
Register here: forms.office.com/r/xVhzcHTy1t
Thank you @judithberman11.bsky.social for organizing! @odedrechavi.bsky.social
March 19, 2025 at 9:57 AM
Israeli friends! Interested in learning & practicing the thinking tools of the creative process in science? Join the Night Science workshop in Tel Aviv University next week!
Register here: forms.office.com/r/xVhzcHTy1t
Thank you @judithberman11.bsky.social for organizing! @odedrechavi.bsky.social
Register here: forms.office.com/r/xVhzcHTy1t
Thank you @judithberman11.bsky.social for organizing! @odedrechavi.bsky.social
Reposted by Bjørt K.Kragesteen
We are hiring! If you are interested in DNA nanotechnology in spatial biology, please apply at:
ki.varbi.com/en/what:job/...
ki.varbi.com/en/what:job/...
Postdoctoral Researcher in DNA nanotechnology for spatial biology
Do you want to contribute to top quality medical research? The Ana Teixeira Lab at the Department of Physiology and Pharmacology, Karolinska Institutet, is seeking talented and motivated postdoctoral
ki.varbi.com
February 20, 2025 at 12:42 PM
We are hiring! If you are interested in DNA nanotechnology in spatial biology, please apply at:
ki.varbi.com/en/what:job/...
ki.varbi.com/en/what:job/...
Reposted by Bjørt K.Kragesteen
A great line-up of speakers for the "Blueprints of life: cell fate choices and lineages" conference @ki.se organized by @anderssonlab.bsky.social
To register 👇
news.ki.se/calendar/blu...
To register 👇
news.ki.se/calendar/blu...
Blueprints of Life: Cell fate choices and lineages
Dive into the fascinating world of cell fate decisions that underlie the variety of cell types in our bodies. Join top researchers in the field to uncover the blueprints of life!
news.ki.se
February 4, 2025 at 8:26 AM
A great line-up of speakers for the "Blueprints of life: cell fate choices and lineages" conference @ki.se organized by @anderssonlab.bsky.social
To register 👇
news.ki.se/calendar/blu...
To register 👇
news.ki.se/calendar/blu...
Reposted by Bjørt K.Kragesteen
🚨 PhD Opportunity in Single-Cell Lineage Tracing! 🚨
We are looking for a highly motivated PhD student to join our ERC-funded project, combining in utero nano-injection, spatial transcriptomics, & single-cell RNAseq to reconstruct lineage trees & uncover fate dynamics.
Apply here: bit.ly/4aEfcvE
We are looking for a highly motivated PhD student to join our ERC-funded project, combining in utero nano-injection, spatial transcriptomics, & single-cell RNAseq to reconstruct lineage trees & uncover fate dynamics.
Apply here: bit.ly/4aEfcvE
Doctoral (PhD) student position in Developmental Biology with in utero next generation single cell lineage tracing
Do you want to contribute to top quality medical research? To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individu
kidoktorand.varbi.com
January 31, 2025 at 9:56 AM
🚨 PhD Opportunity in Single-Cell Lineage Tracing! 🚨
We are looking for a highly motivated PhD student to join our ERC-funded project, combining in utero nano-injection, spatial transcriptomics, & single-cell RNAseq to reconstruct lineage trees & uncover fate dynamics.
Apply here: bit.ly/4aEfcvE
We are looking for a highly motivated PhD student to join our ERC-funded project, combining in utero nano-injection, spatial transcriptomics, & single-cell RNAseq to reconstruct lineage trees & uncover fate dynamics.
Apply here: bit.ly/4aEfcvE