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korolchuklab.bsky.social
Korolchuk Lab
@korolchuklab.bsky.social
2.5K followers 6.1K following 70 posts
Cell biology lab at Newcastle University, UK, molecular mechanisms of nutrient sensing and autophagy, ageing and age-related disease 🇺🇦
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korolchuklab.bsky.social
#Autophagy and #mTOR papers from last three weeks, enjoy!

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...
bims-auttor 2025-10-26 papers
biomed.news
November 9, 2025 at 12:59 PM
korolchuklab.bsky.social
Looking forward to presenting and discussing our data, and making new friends of course!
crc1430.bsky.social CRC 1430 @crc1430.bsky.social · 17d
Looking forward to tomorrow’s
@crc1430.bsky.social seminar
@unidue.bsky.social! We are excited to welcome Viktor Korolchuk
@korolchuklab.bsky.social, who will present on:
"Selective autophagy in ageing: mechanisms and functions"
#Autophagy #CellBiology #Collaboration
October 27, 2025 at 10:23 PM
Reposted by Korolchuk Lab
ericchevet.bsky.social
This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

highlight: Role of AAA-ATPase Cdc48p in peroxisomal quality control www.cell.com/cell-reports...
bims-proteo 2025-10-19 papers
biomed.news
October 19, 2025 at 5:28 AM
Reposted by Korolchuk Lab
frezzalab.bsky.social
Good Sunday, mitolovers! 🌟 Exciting news in the world of #cancermetabolism and #mitochondrialbiology! 🧬 Check out the papers from last week here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading📚

"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
October 19, 2025 at 5:35 AM
korolchuklab.bsky.social
A strong effort by the #autophagy and #mTOR field last week, lots of interesting published papers in the link below 👇🏼

biomed.news/bims-auttor/...
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media.tenor.com
October 19, 2025 at 11:06 AM
Reposted by Korolchuk Lab
odedrechavi.bsky.social
Here's the link to the system, try it! qedscience.com
@qedscience.bsky.social
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
qedscience.com
October 15, 2025 at 12:22 PM
korolchuklab.bsky.social
Proud to be involved in this great paper describing a novel mechanism of #synuclein aggregation with implications for potential #PD treatment, don’t miss it! 👇🏼👇🏼👇🏼
Congratulations to the team!

www.embopress.org/doi/full/10....
Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation | The EMBO Journal
imageimageFibril formation of α-synuclein is central to Parkinson’s disease (PD) pathology. This study shows that UBQLN2 droplets catalyze α-synuclein fibrillization via their liquid-gel/solid transition, while a small molecule targeting UBQLN2 ...
www.embopress.org
October 15, 2025 at 9:14 AM
Reposted by Korolchuk Lab
ericchevet.bsky.social
This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitnes www.science.org/doi/10.1126/...
bims-proteo 2025-10-12 papers
biomed.news
October 12, 2025 at 8:11 AM
Reposted by Korolchuk Lab
cvasilescu.bsky.social
Fresh selection of papers on #MitochondrialDisease from #week41! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
www.science.org
October 12, 2025 at 11:06 AM
Reposted by Korolchuk Lab
frezzalab.bsky.social
Good Sunday, all. Your weekly curated summary of papers in #cancermetabolism and #mitochondrialbiology is ready, don't miss it as it is full of exceptional discoveries: biomed.news/bims-camemi/... Biomed News #keepreading

"To see takes time, like to have a friend takes time." -Georgia O'Keeffe
October 12, 2025 at 5:41 AM
korolchuklab.bsky.social
#Autophagy and #mTOR paper published last week, lots of cool stuff, enjoy!

biomed.news/bims-auttor/...
October 12, 2025 at 9:13 AM
Reposted by Korolchuk Lab
frisophagy.bsky.social
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?

This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.

www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
www.science.org
October 10, 2025 at 8:45 AM
korolchuklab.bsky.social
A new set of guidelines on the use of in vitro models in #PD and #Ageing research #Justpublished, don’t miss it! 👇🏼👇🏼👇🏼

rdcu.be/eKanG
Investigating the ageing-Parkinson’s disease nexus: standardisation of in vitro models and techniques by the PD-AGE network
npj Parkinson's Disease - Investigating the ageing-Parkinson’s disease nexus: standardisation of in vitro models and techniques by the PD-AGE network
rdcu.be
October 9, 2025 at 11:18 AM
Reposted by Korolchuk Lab
wisemanlab.bsky.social
Scripps is conducting a tenure track assistant professor search. This is a broad search across multiple departments for outstanding individuals that could integrate into the multi-disciplinary environment at Scripps Research. All interested should apply! Please share. apply.interfolio.com/174756
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 2, 2025 at 4:33 PM
Reposted by Korolchuk Lab
ericchevet.bsky.social
This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Translation landscape of stress granules www.science.org/doi/10.1126/...
bims-proteo 2025-10-05 papers
biomed.news
October 5, 2025 at 6:28 AM
Reposted by Korolchuk Lab
cvasilescu.bsky.social
#MitochondrialDisease papers from #week40! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

A few highlights below! 👇

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
www.nature.com/articles/s42...
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function - Nature Metabolism
Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.
www.nature.com
October 5, 2025 at 9:33 AM
korolchuklab.bsky.social
#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection engine. DM them if you want your own personalised feed.

biomed.news/bims-auttor/...
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media.tenor.com
October 5, 2025 at 8:51 AM
Reposted by Korolchuk Lab
cvasilescu.bsky.social
#MitochondrialDisease papers from #week39! 📚 👇
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

A few highlights below!
Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature
Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.
nature.com
September 28, 2025 at 10:06 AM
Reposted by Korolchuk Lab
frisophagy.bsky.social
In this week's issue of mitophagy news 🪫🗑️:

-Urolithin A increases healthspan via MERCS and Ca2+-mitophagy
-Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity
-a Parkin and hTau mouse cross

biomed.news/bims-tofagi/...
Urolithin A ameliorates the age-dependent decline of ER-mitochondria contacts and alters intracellular Ca2+ balance.
September 14, 2025 at 11:24 AM
korolchuklab.bsky.social
#Autophagy and #mTOR papers from last 4 weeks, buildup due to laziness but lots of cool stuff here, have a look!

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...
Ive Been Doing A Bunch Of Research Mitchell Moffit GIF
ALT: Ive Been Doing A Bunch Of Research Mitchell Moffit GIF
media.tenor.com
September 28, 2025 at 9:30 PM
korolchuklab.bsky.social
And another amazing #mTOR paper👇🏼Where do people get strength from to put so much work into this?

www.life-science-alliance.org/content/8/11...
Amino acid–dependent TSC2 dephosphorylation by lysosome–PP2A regulates mTORC1 signaling transduction
The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, composed of amino acid (AA)–sensing (Ragulator/LAMTOR-Rag) and growth factor (GF)–sensing (AKT-TSC1/2-Rheb) axes, pivotally regu...
www.life-science-alliance.org
September 4, 2025 at 6:59 PM
korolchuklab.bsky.social
#mTOR research field never ceases to amaze, what a tour de force! 👇🏼

mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal www.embopress.org/doi/full/10....
mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal
imageimageDuring starvation, individual amino acid levels are thought to be relayed via distinct metabolic sensors, but how mTORC1 senses glutamine remains unclear. This study finds that GCN2 kinase acts as a unifying module in suppression of ...
www.embopress.org
September 2, 2025 at 8:29 AM
korolchuklab.bsky.social
www.nature.com/articles/s41...
Structural basis for the dynamic regulation of mTORC1 by amino acids - Nature
Using cryo-electron microscopy, the interactions of Sestrin2 and CASTOR1 with GATOR2 were resolved, revealing how mTORC1 activation is regulated and how nutrient availability triggers signalling for c...
www.nature.com
August 24, 2025 at 8:09 AM
korolchuklab.bsky.social
Proteomic aging signatures across mouse organs and life stages | The EMBO Journal www.embopress.org/doi/full/10....
Proteomic aging signatures across mouse organs and life stages | The EMBO Journal
imageimageGenomic and transcriptomic studies have advanced our system-level understanding of aging, but large-scale proteomic analyses of the underlying processes remain limited. This resource provide...
www.embopress.org
August 19, 2025 at 8:50 AM
korolchuklab.bsky.social
#mTOR and #autophagy papers from last week. Lots of interesting new stuff, enjoy thanks to @biomednews.bsky.social pre-selection!

biomed.news/bims-auttor/...
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August 17, 2025 at 8:21 AM