kostaslekkos.bsky.social
@klekkos.bsky.social
DPhil student @Mommersteeglab @UniofOxford | Heart regeneration | Zebrafish
Why does it matter? As oxidative metabolism is the predominant energy-producing pathway in the human heart, our work paves the way for the identification of targetable pathways to prevent heart failure.
October 1, 2025 at 11:29 AM
Why does it matter? As oxidative metabolism is the predominant energy-producing pathway in the human heart, our work paves the way for the identification of targetable pathways to prevent heart failure.
Upregulation of oxidative metabolism through mdh1ab and malate-aspartate shuttle leads to increased cardiomyocyte re-differentiation, after proliferation has ceased. This response is conserved in the regenerative A. mexicanus surface fish but absent in the non-regenerative cavefish.
October 1, 2025 at 11:28 AM
Upregulation of oxidative metabolism through mdh1ab and malate-aspartate shuttle leads to increased cardiomyocyte re-differentiation, after proliferation has ceased. This response is conserved in the regenerative A. mexicanus surface fish but absent in the non-regenerative cavefish.
#zebrafish #regeneration #heart #OXPHOS #devbio #differentiation
@natcardiovascres.nature.com @idrm.ox.ac.uk @oxforddpag.bsky.social
@natcardiovascres.nature.com @idrm.ox.ac.uk @oxforddpag.bsky.social
October 1, 2025 at 11:27 AM