Kıvanç Görgülü
@kivancgorgulu.bsky.social
Physician-scientist (MD/PhD) with an imagination for creating new concepts in cancer research by multidisciplinary approaches - Metabolism and Metastasis in PDAC - Comprehensive Cancer Center Munich, TUM Universitätsklinikum
Finally, that time of the year again! Which topics and names will go for Nobel?GLP-1, PI3k, chaperone mediated protein folding, imatinib, nuclear hormone receptors, SMA treatment, or CFTR? In the Chemistry field, sequencing or optogenetics🤔Waiting for it!
#nobelprize #medicine #physiology #chemistry
#nobelprize #medicine #physiology #chemistry
October 6, 2025 at 8:31 AM
Finally, that time of the year again! Which topics and names will go for Nobel?GLP-1, PI3k, chaperone mediated protein folding, imatinib, nuclear hormone receptors, SMA treatment, or CFTR? In the Chemistry field, sequencing or optogenetics🤔Waiting for it!
#nobelprize #medicine #physiology #chemistry
#nobelprize #medicine #physiology #chemistry
Happy to be a part of this study in @cp-cancercell.bsky.social !
Many congrats to the Demir Lab for showing that pseudo-synapses between neurons and PDAC cells boost tumor growth! Blocking glutamate-GRIN2D signaling demonstrates promising survival benefits. Hope it can be translated into the clinic!
Many congrats to the Demir Lab for showing that pseudo-synapses between neurons and PDAC cells boost tumor growth! Blocking glutamate-GRIN2D signaling demonstrates promising survival benefits. Hope it can be translated into the clinic!
Online Now: Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses
Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses
Ren et al. demonstrate pseudo-synaptic connections between sensory neurons and pancreatic ductal adenocarcinoma (PDAC) cells. These pseudo-synapses exhibit enrichment of NMDA receptor subunit GRIN2D/GluN2D, enhancing PDAC responsiveness to neuron-derived glutamate and promoting tumor growth. Disrupting glutamate-GRIN2D signaling at pseudo-synapses improves survival in PDAC, highlighting the therapeutic potential of targeting cancer-neuron-pseudo-synapses.
dlvr.it
September 29, 2025 at 3:08 PM
Happy to be a part of this study in @cp-cancercell.bsky.social !
Many congrats to the Demir Lab for showing that pseudo-synapses between neurons and PDAC cells boost tumor growth! Blocking glutamate-GRIN2D signaling demonstrates promising survival benefits. Hope it can be translated into the clinic!
Many congrats to the Demir Lab for showing that pseudo-synapses between neurons and PDAC cells boost tumor growth! Blocking glutamate-GRIN2D signaling demonstrates promising survival benefits. Hope it can be translated into the clinic!
Must read!
One of the most-viewed PNAS articles in the last week is “Antioxidants prevent health-promoting effects of physical exercise in humans.” Explore the article here: www.pnas.org/doi/10.1073/...
For more trending articles, visit ow.ly/Me2U50SkLRZ.
For more trending articles, visit ow.ly/Me2U50SkLRZ.
July 14, 2025 at 9:05 PM
Must read!
It was a great opportunity to have "Meet the Expert Session" during the lunch with the pioneers of the cancer neuroscience field, @michellemonje.bsky.social and @winklerlab.bsky.social at 11. Mildred Scheel Cancer Conference of the DKH! Before Niklas Elmehed draws them, here is the photo!
July 9, 2025 at 4:35 PM
It was a great opportunity to have "Meet the Expert Session" during the lunch with the pioneers of the cancer neuroscience field, @michellemonje.bsky.social and @winklerlab.bsky.social at 11. Mildred Scheel Cancer Conference of the DKH! Before Niklas Elmehed draws them, here is the photo!
Very interesting study!
Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis - Shin - 2025 - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis - Shin - 2025 - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis
REVERT (REVERse Transition) is presented, a systems framework developed to identify a reversion switch in the transition process of tumorigenesis through comprehensive attractor landscape analysis of...
advanced.onlinelibrary.wiley.com
May 19, 2025 at 10:07 AM
Very interesting study!
Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis - Shin - 2025 - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis - Shin - 2025 - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
Amazing study published in @science.org! I cannot think of any front end for its applications 🎉 Congratulations to the authors 🎉
👏🏻
👏🏻
An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...
Measurements of molecular size and shape on a chip
Size and shape are critical discriminators between molecular species and states. We describe a microchip-based high-throughput imaging approach offering rapid and precise determination of molecular pr...
www.science.org
May 9, 2025 at 8:02 PM
Amazing study published in @science.org! I cannot think of any front end for its applications 🎉 Congratulations to the authors 🎉
👏🏻
👏🏻
A very crazy paper published @science.org ! It would be an eye-opening approach for many fields in the future! So, seeing is believing!
April 4, 2025 at 10:17 AM
A very crazy paper published @science.org ! It would be an eye-opening approach for many fields in the future! So, seeing is believing!
An amazing study published @cp-cell.bsky.social from @leventallab.bsky.social is changing our understanding of plasma membranes! Many congratulations to all the authors!
Now online! Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
This work challenges a major assumption in cell biology by showing that lipid bilayers can have drastically different phospholipid abundances between their two leaflets. This lipid abundance asymmetry is enabled by the unique properties of cholesterol and endows biomembranes with distinctive properties and physiological roles.
dlvr.it
April 3, 2025 at 12:06 PM
An amazing study published @cp-cell.bsky.social from @leventallab.bsky.social is changing our understanding of plasma membranes! Many congratulations to all the authors!
Reposted by Kıvanç Görgülü
New paper out 🎇
It has been 13 years since @owenlabuob.bsky.social and co. published a stellar protocol on how to measure membrane order with smart probes! Since then, there has been new dyes, imaging modes and biology! We wrote a protocol for Nature Protocols:
www.nature.com/articles/s41...
It has been 13 years since @owenlabuob.bsky.social and co. published a stellar protocol on how to measure membrane order with smart probes! Since then, there has been new dyes, imaging modes and biology! We wrote a protocol for Nature Protocols:
www.nature.com/articles/s41...
Measuring plasma membrane fluidity using confocal microscopy - Nature Protocols
Membrane fluidity is a crucial feature in understanding cellular physiology. This protocol describes a robust pipeline for measuring plasma membrane fluidity using confocal imaging and new environment...
www.nature.com
February 19, 2025 at 3:58 PM
New paper out 🎇
It has been 13 years since @owenlabuob.bsky.social and co. published a stellar protocol on how to measure membrane order with smart probes! Since then, there has been new dyes, imaging modes and biology! We wrote a protocol for Nature Protocols:
www.nature.com/articles/s41...
It has been 13 years since @owenlabuob.bsky.social and co. published a stellar protocol on how to measure membrane order with smart probes! Since then, there has been new dyes, imaging modes and biology! We wrote a protocol for Nature Protocols:
www.nature.com/articles/s41...
Reposted by Kıvanç Görgülü
What were the most inspiring 2024 discoveries in cancer?
Cancer Discovery asked me, Katherine Aird, Aadel Chaudhuri, Jennifer Guerriero, Shiri Gur-Cohen, Benjamin Izar, Brittany Jenkins, Delphine Merino, Alejo Rodriguez-Fraticelli & Shensi Shen, & here's what we said
aacrjournals.org/cancerdiscov...
Cancer Discovery asked me, Katherine Aird, Aadel Chaudhuri, Jennifer Guerriero, Shiri Gur-Cohen, Benjamin Izar, Brittany Jenkins, Delphine Merino, Alejo Rodriguez-Fraticelli & Shensi Shen, & here's what we said
aacrjournals.org/cancerdiscov...
December 3, 2024 at 3:46 PM
What were the most inspiring 2024 discoveries in cancer?
Cancer Discovery asked me, Katherine Aird, Aadel Chaudhuri, Jennifer Guerriero, Shiri Gur-Cohen, Benjamin Izar, Brittany Jenkins, Delphine Merino, Alejo Rodriguez-Fraticelli & Shensi Shen, & here's what we said
aacrjournals.org/cancerdiscov...
Cancer Discovery asked me, Katherine Aird, Aadel Chaudhuri, Jennifer Guerriero, Shiri Gur-Cohen, Benjamin Izar, Brittany Jenkins, Delphine Merino, Alejo Rodriguez-Fraticelli & Shensi Shen, & here's what we said
aacrjournals.org/cancerdiscov...
A very very interesting study published @cellpress.bsky.social ⚡ Congratulations to the team! Proteolethargy! It seems like the fitness is important even for the proteins!
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Proteolethargy is a pathogenic mechanism in chronic disease
Pathogenic signaling leads to reduced mobility of proteins with diverse functions.
This proteolethargy, which is due to increased oxidation of cysteine residues, may
account for diverse cellular pheno...
www.cell.com
December 2, 2024 at 10:18 AM
A very very interesting study published @cellpress.bsky.social ⚡ Congratulations to the team! Proteolethargy! It seems like the fitness is important even for the proteins!
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Another amazing story from the lab @erturklab.bsky.social 🎉 Many congrats to the authors👏🏻Waiting for the next stories 🤔
Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇
@cellpress.bsky.social
cell.com/cell-host-mi...
@cellpress.bsky.social
cell.com/cell-host-mi...
December 1, 2024 at 10:16 PM
Another amazing story from the lab @erturklab.bsky.social 🎉 Many congrats to the authors👏🏻Waiting for the next stories 🤔
Reposted by Kıvanç Görgülü
I have curated a second "metabolism" starter pack, as the first quickly got full. Please have a look, and I am happy to add others (sorry for those who may appear in both): go.bsky.app/CH1MctZ
November 27, 2024 at 4:22 PM
I have curated a second "metabolism" starter pack, as the first quickly got full. Please have a look, and I am happy to add others (sorry for those who may appear in both): go.bsky.app/CH1MctZ
Very important one 👏🏻
I am very excited to share this preprint led by Cissy Yong.
🧪 This study shows how tumour sampling conditions during surgery can alter the metabolic profile of ccRCC tissues, with major research implications
#Metabolomics
(now with the correct link)
www.researchsquare.com/article/rs-5...
🧪 This study shows how tumour sampling conditions during surgery can alter the metabolic profile of ccRCC tissues, with major research implications
#Metabolomics
(now with the correct link)
www.researchsquare.com/article/rs-5...
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma
Human isotopic tracer studies are fast becoming the gold standard model to study cancer metabolism in vivo. Analysed tissues are typically retrieved after surgical resection, which exposes them to a v...
www.researchsquare.com
November 19, 2024 at 8:47 PM
Very important one 👏🏻