Amphibian expert shares about their work protecting species and raising awareness of these great animals, all on the basis of thoughtful science in conservation.

When budgets are slashed, this work is undermined.

#standupforscience2025

I would like to be added please!

We found that low OXR1 levels in humans correlate with #Alzheimers, so we drove tau-induced toxicity in fly eyes, to see if we could rescue it with OXR1/retromer. Overexpression of OXR1 or retromer genes prevented this toxicity. Lots more to come from this, so stay tuned! Happy to discuss more 😊

We next wanted to see if enhancing the retromer rescues brain degeneration. Not only did it reduce degeneration in brains of flies that had lost OXR1, but it improved age-related #neurodegeneration as well.