Kenneth Chen
@kennethschen.bsky.social
Pediatric hematology/oncology, UT Southwestern | DICER1/DROSHA-driven childhood cancer | www.kennethchenlab.com
Reposted by Kenneth Chen
I’m happy to share our published work in @cp-cellreports.bsky.social! With zebrafish modeling of rhabdomyosarcoma, we showed that PAX3::FOXO1 utilizes homeobox motif recognition to initially bind closed DNA and activate neural programs present in the human disease. www.cell.com/cell-reports...
Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo
Kucinski et al. use embryonic zebrafish modeling to understand initial chromatin regulatory
mechanisms of fusion-driven pediatric rhabdomyosarcoma. They found that the PAX3::FOXO1
oncoprotein function...
www.cell.com
July 23, 2025 at 3:14 PM
I’m happy to share our published work in @cp-cellreports.bsky.social! With zebrafish modeling of rhabdomyosarcoma, we showed that PAX3::FOXO1 utilizes homeobox motif recognition to initially bind closed DNA and activate neural programs present in the human disease. www.cell.com/cell-reports...
Our study, led by Dr. Patricia Tiburcio, showed that blocking protein recycling may help fight anaplastic Wilms Tumor—a rare, aggressive childhood kidney cancer. Combining bortezomib with dactinomycin made tumors more sensitive to treatment in the lab. doi.org/10.1016/j.xc...
June 24, 2025 at 1:43 PM
Our study, led by Dr. Patricia Tiburcio, showed that blocking protein recycling may help fight anaplastic Wilms Tumor—a rare, aggressive childhood kidney cancer. Combining bortezomib with dactinomycin made tumors more sensitive to treatment in the lab. doi.org/10.1016/j.xc...
Congratulations to Claudette Fraire, Kavita Desai, Indumathy Jagadeeswaran, and others, for their work showing how microRNA loss drives a mouse model of a childhood cancer called pineoblastoma! @genesdev.bsky.social genesdev.cshlp.org/cgi/content/...
April 23, 2025 at 8:31 PM
Congratulations to Claudette Fraire, Kavita Desai, Indumathy Jagadeeswaran, and others, for their work showing how microRNA loss drives a mouse model of a childhood cancer called pineoblastoma! @genesdev.bsky.social genesdev.cshlp.org/cgi/content/...
Nice work Sun, Josh, Tu, and others!
It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation
Cancer cells frequently enhance ribosome production to support rapid growth. Here,
Lee et al. demonstrate that an isoform of lncRNA CRNDE containing an ultraconserved
element (CRNDEUCE) promotes 60S r...
www.cell.com
April 3, 2025 at 5:47 PM
Nice work Sun, Josh, Tu, and others!
Reposted by Kenneth Chen
How can new approaches in early detection make a difference for pediatric cancers? In the new episode Believe in Progress podcast, we speak with Dr. Kris Ann P. Schultz, a pediatric oncologist, about how research is reshaping pediatric cancer care: www.youtube.com/playlist?lis...
April 2, 2025 at 8:20 PM
How can new approaches in early detection make a difference for pediatric cancers? In the new episode Believe in Progress podcast, we speak with Dr. Kris Ann P. Schultz, a pediatric oncologist, about how research is reshaping pediatric cancer care: www.youtube.com/playlist?lis...
Reposted by Kenneth Chen
An email obtained by NPR says NIH employees are subject to a travel freeze and offers of employment are being rescinded. Scientists worry about disruptions to critical research.
National Institutes of Health cancels scientific meetings after Trump directives
An email obtained by NPR says NIH employees are subject to a travel freeze and offers of employment are being rescinded. Scientists worry about disruptions to critical research.
www.npr.org
January 23, 2025 at 6:54 PM
An email obtained by NPR says NIH employees are subject to a travel freeze and offers of employment are being rescinded. Scientists worry about disruptions to critical research.
Reposted by Kenneth Chen
H12TORY MADE 🏆
January 21, 2025 at 4:10 AM
H12TORY MADE 🏆
Reposted by Kenneth Chen
Childhood cancer deaths in the United States have declined six-fold over the last seventy years
January 9, 2025 at 10:13 PM
Childhood cancer deaths in the United States have declined six-fold over the last seventy years
Why haven't childhood cancers respond to immune checkpoint inhibitors (ICIs) like adult cancers?
New preprint from the lab!
PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
www.biorxiv.org/content/10.1...
New preprint from the lab!
PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
www.biorxiv.org/content/10.1...
PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
Inhibition of immune checkpoint proteins is effective in adult cancers but has shown limited efficacy in pediatric cancers. While factors regulating expression of immune checkpoint proteins such as PD...
www.biorxiv.org
December 4, 2024 at 4:10 PM
Why haven't childhood cancers respond to immune checkpoint inhibitors (ICIs) like adult cancers?
New preprint from the lab!
PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
www.biorxiv.org/content/10.1...
New preprint from the lab!
PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
www.biorxiv.org/content/10.1...
Reposted by Kenneth Chen
Let's build a starter pack for childhood cancer research.
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM
November 24, 2024 at 3:27 PM
Let's build a starter pack for childhood cancer research.
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM
Reposted by Kenneth Chen
I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....
www.science.org
November 22, 2024 at 6:09 PM
I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Hello, new friends and old.
November 20, 2024 at 7:16 PM
Hello, new friends and old.