Genevieve Kendall, PhD
@kendalllab.bsky.social
PI at Nationwide Children’s Hospital and Assistant Professor at Ohio State. Studying fusion-driven pediatric sarcomas using a cross-species comparative oncology approach. 🐟🧬🐭 Views are mine.
Beautiful work!
October 9, 2025 at 9:12 PM
Beautiful work!
Congratulations!!! Beautiful work!
September 4, 2025 at 5:04 PM
Congratulations!!! Beautiful work!
Thanks Matt! Same to you!
August 20, 2025 at 9:07 PM
Thanks Matt! Same to you!
All research areas focused on pediatric cancer will be considered, with an emphasis on developmental biology, epigenetics, functional genomics, model development, transcriptional regulation, cell, oncolytic viral and gene therapy, or computational approaches.
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Faculty Position - Center for Childhood Cancer - Columbus, Ohio job with Nationwide Children's Hospital | 12843640
New Faculty Opportunity – Center for Childhood Cancer Research at Nationwide Children’s Hospital
www.nature.com
August 20, 2025 at 4:01 PM
All research areas focused on pediatric cancer will be considered, with an emphasis on developmental biology, epigenetics, functional genomics, model development, transcriptional regulation, cell, oncolytic viral and gene therapy, or computational approaches.
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Thank you to our collaborators - what a fantastic team. And we are incredibly grateful to our funders, including the NIH/NCI, Alex’s Lemonade Stand Foundation, the V Foundation for Cancer Research, St Baldrick’s Foundation, American Cancer Society, and CancerFree Kids for supporting our research.🎗️💛
July 25, 2025 at 5:30 PM
Thank you to our collaborators - what a fantastic team. And we are incredibly grateful to our funders, including the NIH/NCI, Alex’s Lemonade Stand Foundation, the V Foundation for Cancer Research, St Baldrick’s Foundation, American Cancer Society, and CancerFree Kids for supporting our research.🎗️💛
We summarized our findings in this illustration (Credit: Mandy Root-Thompson) depicting zebrafish models to understand the fusion oncogene’s earliest activities, including invading closed DNA (TAAT wrapped around pebbles) or open DNA (GATTACA in plants) to activate neural programs.
July 25, 2025 at 5:30 PM
We summarized our findings in this illustration (Credit: Mandy Root-Thompson) depicting zebrafish models to understand the fusion oncogene’s earliest activities, including invading closed DNA (TAAT wrapped around pebbles) or open DNA (GATTACA in plants) to activate neural programs.
We found that PAX3::FOXO1 invades inaccessible chromatin and induces neural programs as one of its earliest activities. We hope to leverage these new models to find actionable targets for children with rhabdomyosarcoma.
Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo
Kucinski et al. use embryonic zebrafish modeling to understand initial chromatin regulatory
mechanisms of fusion-driven pediatric rhabdomyosarcoma. They found that the PAX3::FOXO1
oncoprotein function...
www.cell.com
July 25, 2025 at 5:30 PM
We found that PAX3::FOXO1 invades inaccessible chromatin and induces neural programs as one of its earliest activities. We hope to leverage these new models to find actionable targets for children with rhabdomyosarcoma.
These studies were led by graduate students @jackkucinski.bsky.social and Alexi Tallan as part of their dissertation research. We wanted to understand how PAX3::FOXO1 initially interfaces with #chromatin in vivo and developed a new #zebrafish model and analytical pipeline to do so.
Highly quantitative measurement of differential protein-genome binding with PerCell chromatin sequencing
Tallan et al. report a versatile approach for highly quantitative protein-genome binding,
demonstrating applications for human and zebrafish cells. The proposed PerCell methodology
and analysis strate...
www.cell.com
July 25, 2025 at 5:30 PM
These studies were led by graduate students @jackkucinski.bsky.social and Alexi Tallan as part of their dissertation research. We wanted to understand how PAX3::FOXO1 initially interfaces with #chromatin in vivo and developed a new #zebrafish model and analytical pipeline to do so.
Congratulations!!! 🎉
July 9, 2025 at 1:14 AM
Congratulations!!! 🎉