Keller Lab
@kellerlab.bsky.social
Updates from the Nancy Keller Lab at the University of Wisconsin-Madison
Fungal genetics, genomics, and secondary metabolism. 🍄 Managed by grad students
Fungal genetics, genomics, and secondary metabolism. 🍄 Managed by grad students
Reposted by Keller Lab
Excited to share our new preprint in collaboration with @kellerlab.bsky.social! We identified unstable aneuploidy in Aspergillus fumigatus and explore how aneuploidy-mediated transcriptional and metabolic changes influence antifungal resistance.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Whole-chromosome duplications drive antimicrobial resistance in Aspergillus fumigatus
Aneuploidy causes genome plasticity and enables adaptive responses that confer drug resistance in eukaryotes ranging from fungal pathogens to human cancer cells. Aspergillus fumigatus is a soil-reside...
www.biorxiv.org
October 4, 2025 at 9:53 PM
Excited to share our new preprint in collaboration with @kellerlab.bsky.social! We identified unstable aneuploidy in Aspergillus fumigatus and explore how aneuploidy-mediated transcriptional and metabolic changes influence antifungal resistance.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Keller Lab
Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation
Penicillium solitum over 8 years in a cheese cave => green-to-white shift
@currentbiology.bsky.social from @benwolfe.bsky.social with @kellerlab.bsky.social
www.cell.com/current-biol...
Penicillium solitum over 8 years in a cheese cave => green-to-white shift
@currentbiology.bsky.social from @benwolfe.bsky.social with @kellerlab.bsky.social
www.cell.com/current-biol...
Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation
Using a unique longitudinal sampling approach, Louw et al. demonstrate how a cheese-associated
Penicillium population has adapted in an artisan cheese production facility in Vermont,
USA. Adaptation i...
www.cell.com
September 14, 2025 at 12:03 PM
Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation
Penicillium solitum over 8 years in a cheese cave => green-to-white shift
@currentbiology.bsky.social from @benwolfe.bsky.social with @kellerlab.bsky.social
www.cell.com/current-biol...
Penicillium solitum over 8 years in a cheese cave => green-to-white shift
@currentbiology.bsky.social from @benwolfe.bsky.social with @kellerlab.bsky.social
www.cell.com/current-biol...
New publication with the Huttenlocher Lab! Led by PhD candidate Nayanna Mercado Soto, we used zebrafish to study burn wound infections with Candida albicans & Aspergillus fumigatus, showing the innate immune response is highly conserved across fungal species. #fungi journals.asm.org/doi/10.1128/...
Larval zebrafish burn wound infection model reveals conserved innate immune responses against diverse pathogenic fungi | mBio
Secondary fungal infections within burn wound injuries are a significant problem that
delays wound healing and increases the risk of patient mortality. Currently, little
is known about how fungi colon...
journals.asm.org
April 16, 2025 at 6:40 PM
New publication with the Huttenlocher Lab! Led by PhD candidate Nayanna Mercado Soto, we used zebrafish to study burn wound infections with Candida albicans & Aspergillus fumigatus, showing the innate immune response is highly conserved across fungal species. #fungi journals.asm.org/doi/10.1128/...