Kelsey Nemec
@kel-nem.bsky.social
Postdoc at Seattle Children's. Proud alum of Penn and UW-Madison. Enthusiast of neuroimmunology, glia, and treating pediatric brain tumors 🧠. Forever cheesehead 🧀. Total beer snob 🍺. she/her
📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠
tinyurl.com/3wvmm8v3
tinyurl.com/3wvmm8v3
Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
Microglia replacement holds great promise for the study and treatment of neurological diseases. We previously achieved high-efficiency replacement by …
tinyurl.com
November 12, 2025 at 10:41 PM
📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠
tinyurl.com/3wvmm8v3
tinyurl.com/3wvmm8v3
Here's the thing. Do I believe the science? Yes. But would I sacrifice slightly better overall physical health for an (at minimum) 2x bump in mental health daily? There is literally no question. I don't need sun while sipping my coffee alone. I need it when I'm trying to have a social life post 5pm.
“Most people would experience the least circadian burden under permanent Standard Time, which prioritizes morning light.” #DitchDST #SaveStandardTime
September 26, 2025 at 9:23 PM
Here's the thing. Do I believe the science? Yes. But would I sacrifice slightly better overall physical health for an (at minimum) 2x bump in mental health daily? There is literally no question. I don't need sun while sipping my coffee alone. I need it when I'm trying to have a social life post 5pm.
Reposted by Kelsey Nemec
Let's be clear: no one should be taking medical advice from the man who told Americans to inject bleach.
To moms worried about the Tylenol they took while pregnant: you deserve better than being RFK Jr's scapegoat.
And to the autism community: you are loved exactly as you are.
To moms worried about the Tylenol they took while pregnant: you deserve better than being RFK Jr's scapegoat.
And to the autism community: you are loved exactly as you are.
September 23, 2025 at 7:20 PM
Let's be clear: no one should be taking medical advice from the man who told Americans to inject bleach.
To moms worried about the Tylenol they took while pregnant: you deserve better than being RFK Jr's scapegoat.
And to the autism community: you are loved exactly as you are.
To moms worried about the Tylenol they took while pregnant: you deserve better than being RFK Jr's scapegoat.
And to the autism community: you are loved exactly as you are.
Had the best time at the 17th annual @seattlechildrens.org Run of Hope benefiting pediatric cancer research! Over half a million dollars raised, and a lovely morning spent with friends, colleagues, and families who give meaning to everything we do. A very bright day in these not so bright times 🏃♀️ ☀️
September 22, 2025 at 3:14 AM
Had the best time at the 17th annual @seattlechildrens.org Run of Hope benefiting pediatric cancer research! Over half a million dollars raised, and a lovely morning spent with friends, colleagues, and families who give meaning to everything we do. A very bright day in these not so bright times 🏃♀️ ☀️
My favorite training question.
September 8, 2025 at 8:20 PM
My favorite training question.
Had a great time at my first #SeattleStorm game today with fellow @seattlechildrens.org Ben Towne Center scientists and friends! #EveryoneWatchesWomensSports
August 4, 2025 at 12:32 AM
Had a great time at my first #SeattleStorm game today with fellow @seattlechildrens.org Ben Towne Center scientists and friends! #EveryoneWatchesWomensSports
Reposted by Kelsey Nemec
Given the recent and devastating cuts to the NIH, my colleagues and I from @seattlechildrens.org are running a 5k on 9/21 to raise money for pediatric cancer research. Please consider donating, joining our team, or simply sharing this post to help raise awareness! #EndDIPG
runsignup.com/nemec
runsignup.com/nemec
Kelsey Nemec - Run of Hope Seattle
Recent federal cuts to the NIH and the projected cuts to Medicaid will devastate health care and scientific advancements for all Americans. We will likely lose a generation of young scientists given t...
www.runofhopeseattle.org
July 29, 2025 at 5:27 PM
Given the recent and devastating cuts to the NIH, my colleagues and I from @seattlechildrens.org are running a 5k on 9/21 to raise money for pediatric cancer research. Please consider donating, joining our team, or simply sharing this post to help raise awareness! #EndDIPG
runsignup.com/nemec
runsignup.com/nemec
I thought this was a Magic Eye and spent an embarrassing amount of time trying to see the hidden figure before actually reading the caption of the post.
Stronger than steel, lighter than aluminum, and highly conductive—#graphene has huge potential. So why isn’t it everywhere? It’s hard and costly to make. A new method could change that and boost #SustainableElectronics.
Read more: www.pnas.org/doi/10.1073/...
#lasers #sustainability
Read more: www.pnas.org/doi/10.1073/...
#lasers #sustainability
July 9, 2025 at 5:52 PM
I thought this was a Magic Eye and spent an embarrassing amount of time trying to see the hidden figure before actually reading the caption of the post.
Reposted by Kelsey Nemec
How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧵 www.nature.com/articles/s41...
July 8, 2025 at 12:00 AM
How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧵 www.nature.com/articles/s41...
Honeymooning in New Zealand when I got the notice that the final version of my thesis paper is out! Huge thank you to the @elife.bsky.social editors and reviewers for making this the smoothest review process I’ve ever had. Give it a read! #microglia #AGS 🤓🧠
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutières Syndrome neuropathology
elifesciences.org
June 30, 2025 at 7:43 PM
Honeymooning in New Zealand when I got the notice that the final version of my thesis paper is out! Huge thank you to the @elife.bsky.social editors and reviewers for making this the smoothest review process I’ve ever had. Give it a read! #microglia #AGS 🤓🧠
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Reposted by Kelsey Nemec
I am looking for a postdoc with an immunology background interested in joining a Yale neuroscience lab to study how the brain controls immunity. At Yale, we have a wonderful interdisciplinary & collaborative #neuroimmune community. Please reach out or share with anyone who might be interested!
May 22, 2025 at 11:42 AM
I am looking for a postdoc with an immunology background interested in joining a Yale neuroscience lab to study how the brain controls immunity. At Yale, we have a wonderful interdisciplinary & collaborative #neuroimmune community. Please reach out or share with anyone who might be interested!
Reposted by Kelsey Nemec
We've launched the Armamentarium, a new toolkit for targeted gene delivery to the brain and spinal cord.
This #OpenScience resource was made possible thanks to support from the NIH BRAIN Initiative and teamwork with our collaborators.
🧠📈 www.nih.gov/news-events/...
This #OpenScience resource was made possible thanks to support from the NIH BRAIN Initiative and teamwork with our collaborators.
🧠📈 www.nih.gov/news-events/...
Scientists design gene delivery systems for cells in the brain and spinal cord
NIH-funded breakthrough could enable targeted therapies for many neurological disorders.
www.nih.gov
May 21, 2025 at 6:25 PM
We've launched the Armamentarium, a new toolkit for targeted gene delivery to the brain and spinal cord.
This #OpenScience resource was made possible thanks to support from the NIH BRAIN Initiative and teamwork with our collaborators.
🧠📈 www.nih.gov/news-events/...
This #OpenScience resource was made possible thanks to support from the NIH BRAIN Initiative and teamwork with our collaborators.
🧠📈 www.nih.gov/news-events/...
Reposted by Kelsey Nemec
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease
Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains
is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets
and lose their phagocytic cap...
www.cell.com
May 19, 2025 at 6:14 PM
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
Had a great time at #SNOPeds2025 this weekend! Thanks to @neuroonc.bsky.social for putting on such a fun and informative conference, and for having it in a city that provided some much needed spring warmth ☀️ 🌴 ☺️
May 17, 2025 at 11:15 PM
Had a great time at #SNOPeds2025 this weekend! Thanks to @neuroonc.bsky.social for putting on such a fun and informative conference, and for having it in a city that provided some much needed spring warmth ☀️ 🌴 ☺️
Reposted by Kelsey Nemec
Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j49xBy
May 15, 2025 at 5:09 PM
Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j49xBy
Reposted by Kelsey Nemec
Our May featured #FacultySpotlight is Dr. Ana Cristancho, CHOP neurologist. In her Q&A, Dr. Cristancho discusses her work investigating the mechanisms underlying the long-term effects of early-life brain injuries. http://ms.spr.ly/63325SZSdd
May 14, 2025 at 4:49 PM
Our May featured #FacultySpotlight is Dr. Ana Cristancho, CHOP neurologist. In her Q&A, Dr. Cristancho discusses her work investigating the mechanisms underlying the long-term effects of early-life brain injuries. http://ms.spr.ly/63325SZSdd
Reposted by Kelsey Nemec
The #RunofHope is an annual fundraiser for the Seattle Children's #pediatriccancer & blood disorders research. Please consider joining us and/or making a donation. No amount is too small! All donations to our team will go to the Brain Tumor Research Program
runsignup.com/cartforkids
runsignup.com/cartforkids
Mario CAR Ts for Kids - Run of Hope Seattle
The fact that some brain and spinal cord tumors are incurable is unacceptable. The fact that so many standard treatments have so many side effects is unacceptable. The fact that when tumors recur ther...
runsignup.com
May 2, 2025 at 4:00 AM
The #RunofHope is an annual fundraiser for the Seattle Children's #pediatriccancer & blood disorders research. Please consider joining us and/or making a donation. No amount is too small! All donations to our team will go to the Brain Tumor Research Program
runsignup.com/cartforkids
runsignup.com/cartforkids
The first photo was what I posted on my Instagram story last night. 18 hours later and I’ve signed up to run a 5k. Y’all I *hate* running. But I’m doing it to raise money for our center to fund pediatric cancer research. Plz considering supporting us! 🏃♀️🫣⬇️
www.runofhopeseattle.org/Race/93971/D...
www.runofhopeseattle.org/Race/93971/D...
May 1, 2025 at 11:35 PM
The first photo was what I posted on my Instagram story last night. 18 hours later and I’ve signed up to run a 5k. Y’all I *hate* running. But I’m doing it to raise money for our center to fund pediatric cancer research. Plz considering supporting us! 🏃♀️🫣⬇️
www.runofhopeseattle.org/Race/93971/D...
www.runofhopeseattle.org/Race/93971/D...
Reposted by Kelsey Nemec
Thrilled that @chopresearch.bsky.social highlighted our latest work published today in @cp-immunity.bsky.social
www.chop.edu/news/preclin...
www.chop.edu/news/preclin...
Preclinical Study from Children’s Hospital of Philadelphia Highlights Innovative Approach to Replacing Brain Cells in the Treatment of Leukodystrophies
Researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania announced the first ever direct approach to the depletion and replacemen...
www.chop.edu
April 30, 2025 at 3:58 PM
Thrilled that @chopresearch.bsky.social highlighted our latest work published today in @cp-immunity.bsky.social
www.chop.edu/news/preclin...
www.chop.edu/news/preclin...
Reposted by Kelsey Nemec
Very happy for having contributed to this amazing study led by Jonathan Bastos and Kia Movahedi. Super cool findings! @sotonbiosciences.bsky.social @cp-immunity.bsky.social @liambc.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia
Microglia and border-associated macrophages (BAMs) are critical for brain health, and their dysfunction is associated to disease. Replacing brain macr…
www.sciencedirect.com
April 30, 2025 at 3:44 PM
Very happy for having contributed to this amazing study led by Jonathan Bastos and Kia Movahedi. Super cool findings! @sotonbiosciences.bsky.social @cp-immunity.bsky.social @liambc.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Amped to share this masterclass of a paper spearheaded by @waisenberg.bsky.social, out today in Immunity. Will et al. provide a deeply detailed look into microglia dysfunction in Krabbe disease & show that microglia replacement therapeutically improves disease outcomes!
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell
leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular
signature of disease-associated ...
www.cell.com
April 30, 2025 at 4:32 PM
Amped to share this masterclass of a paper spearheaded by @waisenberg.bsky.social, out today in Immunity. Will et al. provide a deeply detailed look into microglia dysfunction in Krabbe disease & show that microglia replacement therapeutically improves disease outcomes!
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Kelsey Nemec
Next up is NGG graduate Evan Gallagher’s work! Current NGG student Kara McGaughey @kara-mcgaughey.bsky.social explains how he investigated the novel positron emission tomography (PET) radioligand [18F]ROStrace as a possible in vivo biomarker for Parkinson's disease. www.upennglia.com/briefs/bib-p...
A NEW APPROACH TO IMAGING THE BRAIN DURING EARLY-STAGE NEURODEGENERATION — GLIA
or technically, Positron Emission Tomography with [ 18 F]ROStrace Reveals Progressive Elevations in Oxidative Stress in a Mouse Model of Alpha-Synucleinopathy [See original abstract on Pubmed]
www.upennglia.com
April 21, 2025 at 4:41 PM
Next up is NGG graduate Evan Gallagher’s work! Current NGG student Kara McGaughey @kara-mcgaughey.bsky.social explains how he investigated the novel positron emission tomography (PET) radioligand [18F]ROStrace as a possible in vivo biomarker for Parkinson's disease. www.upennglia.com/briefs/bib-p...
Incredible news from @nickvitanza.bsky.social et al! A timely reminder that what (the universal) we do is important and worth fighting for.
Breakthrough Therapy designation gives us the possibility to accelerate the development path for BCB-276 as a CAR T-cell therapy to potentially transform treatment of #DIPG, an incurable brain tumor. Our #CARTcells approach opens a new paradigm for other CNS brain tumors.
www.brainchildbio.com/press
www.brainchildbio.com/press
April 22, 2025 at 3:42 PM
Incredible news from @nickvitanza.bsky.social et al! A timely reminder that what (the universal) we do is important and worth fighting for.
Reposted by Kelsey Nemec
Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Let’s hope others follow suit.
April 15, 2025 at 3:52 AM
Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Let’s hope others follow suit.