Izhak Kehat
@kehat.bsky.social
Head, Dept. of Physiology, Faculty of Medicine, Technion. Cardiologist. Mediocre cook. Sarcomeres, gene expression
Views are my own
Views are my own
Found in translation: Using single-molecule imaging, we show that ERK signaling controls where protein translation happens during hypertrophic stimulation in #cardiomyocytes —revealing a dynamic, localized response. #Biorxivpreprint #cardiosky
Read: www.biorxiv.org/content/10.1...
Read: www.biorxiv.org/content/10.1...
Single molecule imaging reveals extracellular signal-regulated kinases dependent signal responsive spatial regulation of translation in cardiomyocytes
Background Translational control of gene expression is crucial in cardiomyocytes, particularly in response to hypertrophic stimuli. The extracellular signal-regulated kinases (ERK) pathway plays a key...
www.biorxiv.org
May 8, 2025 at 1:08 PM
Found in translation: Using single-molecule imaging, we show that ERK signaling controls where protein translation happens during hypertrophic stimulation in #cardiomyocytes —revealing a dynamic, localized response. #Biorxivpreprint #cardiosky
Read: www.biorxiv.org/content/10.1...
Read: www.biorxiv.org/content/10.1...
Imagine if we cited preprints by default, even after journal publication. Time to burst the impact factor bubble?
April 22, 2025 at 1:49 PM
Imagine if we cited preprints by default, even after journal publication. Time to burst the impact factor bubble?
In music, even famous artists cover songs, and some bands play almost exclusively covers. What if science had the same? “In this manuscript, we’re covering the classic paper from ‘04.”
March 24, 2025 at 12:18 PM
In music, even famous artists cover songs, and some bands play almost exclusively covers. What if science had the same? “In this manuscript, we’re covering the classic paper from ‘04.”
Still waiting for a study that doesn’t end with “more research is needed.” Just one that says, “That’s it. We’ve figured it out.”
February 14, 2025 at 7:03 AM
Still waiting for a study that doesn’t end with “more research is needed.” Just one that says, “That’s it. We’ve figured it out.”
Reposted by Izhak Kehat
Many academics point to bioRxiv as “the one thing improving science publishing”.
If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
December 21, 2024 at 2:01 PM
Many academics point to bioRxiv as “the one thing improving science publishing”.
If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
Should we create an academic cryptocurrency? Mining would happen through peer reviews and committee meetings, eventually convertible to the ultimate hard currency: pizza
December 18, 2024 at 8:22 PM
Should we create an academic cryptocurrency? Mining would happen through peer reviews and committee meetings, eventually convertible to the ultimate hard currency: pizza
Reposted by Izhak Kehat
🚨📢Paper alert! Real progress on identifying why residual force enhancement occurs in skeletal muscle! This was a study I dreamed about since grad school. Please share! 🔬💪🧪
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
December 16, 2024 at 10:03 PM
🚨📢Paper alert! Real progress on identifying why residual force enhancement occurs in skeletal muscle! This was a study I dreamed about since grad school. Please share! 🔬💪🧪
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Izhak Kehat
Some of the big news we report: "...suggesting that upon activation, [I-band] titin stiffness increased ~2.2 to 3.1 times compared to the passive state"
#MyoBlue
#MyoBlue
🚨📢Paper alert! Real progress on identifying why residual force enhancement occurs in skeletal muscle! This was a study I dreamed about since grad school. Please share! 🔬💪🧪
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
December 16, 2024 at 10:38 PM
Some of the big news we report: "...suggesting that upon activation, [I-band] titin stiffness increased ~2.2 to 3.1 times compared to the passive state"
#MyoBlue
#MyoBlue
Reposted by Izhak Kehat
The Church of the FSM Holiday e-Card Machine is live again with new designs. Please send festive greetings to your friends and family.
app.spaghettimonster.org/card/create
app.spaghettimonster.org/card/create
December 9, 2024 at 12:19 PM
The Church of the FSM Holiday e-Card Machine is live again with new designs. Please send festive greetings to your friends and family.
app.spaghettimonster.org/card/create
app.spaghettimonster.org/card/create
I like to celebrate the small victories in science. For example, today I fixed the lab vacuum trap
December 5, 2024 at 12:43 PM
I like to celebrate the small victories in science. For example, today I fixed the lab vacuum trap
Idea: develop a new method and use it to uncover lots of cool new biology
Reality: develop a new method and use it on one well known and well characterized piece of biology
Reality: develop a new method and use it on one well known and well characterized piece of biology
December 4, 2024 at 1:16 PM
Idea: develop a new method and use it to uncover lots of cool new biology
Reality: develop a new method and use it on one well known and well characterized piece of biology
Reality: develop a new method and use it on one well known and well characterized piece of biology
Is the difference in the impact factors between journal statistically significant? Journal should specify the statistical test used, n, and exact p value when referring to their JIF
November 26, 2024 at 12:25 PM
Is the difference in the impact factors between journal statistically significant? Journal should specify the statistical test used, n, and exact p value when referring to their JIF
Reposted by Izhak Kehat
We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at:
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
November 25, 2024 at 2:44 PM
We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at:
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
Organizing academics is like herding cats—both are much easier with pizza involved
November 25, 2024 at 5:45 PM
Organizing academics is like herding cats—both are much easier with pizza involved
Maybe editors should just invite reviewer # 1,2, and 4?
November 21, 2024 at 8:49 PM
Maybe editors should just invite reviewer # 1,2, and 4?
Like paring of food and wine, I am in favor of pairing music to lab experiments. In my experience Neil Young works great with RNA extraction.
November 20, 2024 at 2:37 PM
Like paring of food and wine, I am in favor of pairing music to lab experiments. In my experience Neil Young works great with RNA extraction.
I wish there was at least one student in class that looked at me that intently
November 19, 2024 at 6:53 PM
I wish there was at least one student in class that looked at me that intently
I see remarks in grants review about applicants productivity. How is that measured? I suggest printing out and weighing the papers the applicant wrote, multiply be impact of journal and divide by time. Unit of 1 gr•impact/ year or 1 Clarivate
November 18, 2024 at 5:50 PM
I see remarks in grants review about applicants productivity. How is that measured? I suggest printing out and weighing the papers the applicant wrote, multiply be impact of journal and divide by time. Unit of 1 gr•impact/ year or 1 Clarivate
Like the game where we answer questions without using any of the four forbidden words: yes, no, black or white, can we review a paper without using: mechanism, in vivo , and rigor?
November 15, 2024 at 8:09 PM
Like the game where we answer questions without using any of the four forbidden words: yes, no, black or white, can we review a paper without using: mechanism, in vivo , and rigor?
www.biorxiv.org/content/10.1...
Our new study reveals a new model of sarcomere turnover. Current model proposes recycling of sarcomeric proteins, but our study found newly translated proteins are added while assembled proteins are removed and degraded without recycling.
Our new study reveals a new model of sarcomere turnover. Current model proposes recycling of sarcomeric proteins, but our study found newly translated proteins are added while assembled proteins are removed and degraded without recycling.
September 4, 2023 at 7:13 PM
www.biorxiv.org/content/10.1...
Our new study reveals a new model of sarcomere turnover. Current model proposes recycling of sarcomeric proteins, but our study found newly translated proteins are added while assembled proteins are removed and degraded without recycling.
Our new study reveals a new model of sarcomere turnover. Current model proposes recycling of sarcomeric proteins, but our study found newly translated proteins are added while assembled proteins are removed and degraded without recycling.
It was a bit hot after the walk so he decided to cool down a bit
September 2, 2023 at 5:03 AM
It was a bit hot after the walk so he decided to cool down a bit