Congratulations to Ning Shen on her brilliant PhD defence earlier this week!! 💐👩🏻‍🎓 I'm extremely lucky to have worked with Ning over the past several years.

We show that decemedip can identify tissue-of-origin in many bulk tumour samples as well as in cell-free DNA from cancer patients, and these latter estimates are correlated with parallel measurements of circulating tumour DNA content.

In addition to estimating cell type proportions and their uncertainty intervals, decemedip translates cross-platform measurements between MeDIP-seq counts and fractional methylation levels.

We present decemedip, a reference-based model to estimate cell type composition of immunoprecipitation-based DNA methylomes (MeDIP-seq). While tools exist for deconvoluting absolute methylation levels (BS-seq), this is the first approach applicable to efficient affinity-enrichment protocols.

It's that time of year! (thought a little delayed for us in Canada due to the postal strike...)

Korthauer lab members (and friends) recently tried our hands at the sport of curling! It was fun to all be beginners together.

A running start for day 2 of #STATGEN2024 with a lovely group jog through Schenley Park!

Excited to lead a session on "Deciphering the genomic and epigenomic landscape of cell-free DNA" this afternoon!