Kavli Institute for Nanoscience Discovery, University of Oxford
@kavlioxford.bsky.social
Catalysing discovery by bringing the physical sciences into the cell.
By combining in vitro, in cellulo, and in vivoapproaches within the MIGRATE collaboration (migrate.web.ox.ac.uk/home), she hopes to contribute to our understanding of how the brain builds a regulated and interconnected network.
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September 10, 2025 at 9:43 AM
By combining in vitro, in cellulo, and in vivoapproaches within the MIGRATE collaboration (migrate.web.ox.ac.uk/home), she hopes to contribute to our understanding of how the brain builds a regulated and interconnected network.
Amy’s work focuses on the structure and function of cell adhesion molecules involved in brain development. She aims to link molecular structure to biological function and physiological roles.
September 10, 2025 at 9:43 AM
Amy’s work focuses on the structure and function of cell adhesion molecules involved in brain development. She aims to link molecular structure to biological function and physiological roles.
By understanding how to target PCFT over RFC transporter will help to reduce the toxicity associated with anticancer drug treatment, an impediment to the existing chemotherapy.
#StructuralBiology, #cryoEM, #DrugTransport, #ProstaglandinUptake, #FolateUptake, #CancerTherapy, #AntiInflammatoryDrug
#StructuralBiology, #cryoEM, #DrugTransport, #ProstaglandinUptake, #FolateUptake, #CancerTherapy, #AntiInflammatoryDrug
September 3, 2025 at 8:57 AM
By understanding how to target PCFT over RFC transporter will help to reduce the toxicity associated with anticancer drug treatment, an impediment to the existing chemotherapy.
#StructuralBiology, #cryoEM, #DrugTransport, #ProstaglandinUptake, #FolateUptake, #CancerTherapy, #AntiInflammatoryDrug
#StructuralBiology, #cryoEM, #DrugTransport, #ProstaglandinUptake, #FolateUptake, #CancerTherapy, #AntiInflammatoryDrug
However, cancer cells (specifically solid tumours) take up the folate nutrient via proton-coupled folate transporter (PCFT) which has an acidic pH optimum.
September 3, 2025 at 8:57 AM
However, cancer cells (specifically solid tumours) take up the folate nutrient via proton-coupled folate transporter (PCFT) which has an acidic pH optimum.
The main cause of cell toxicity is the uptake of the chemotherapy drugs such as antifolates into healthy tissues via a folate transporter; Reduced Folate carrier (RFC) which works at the neutral pH.
September 3, 2025 at 8:57 AM
The main cause of cell toxicity is the uptake of the chemotherapy drugs such as antifolates into healthy tissues via a folate transporter; Reduced Folate carrier (RFC) which works at the neutral pH.
In another project focussed on human proton-coupled folate (PCFT; SLC46A1) membrane transporter, Chitra is delineating structures of PCFT with a novel antifolate library which will prove instrumental for structure-based drug designing.
September 3, 2025 at 8:57 AM
In another project focussed on human proton-coupled folate (PCFT; SLC46A1) membrane transporter, Chitra is delineating structures of PCFT with a novel antifolate library which will prove instrumental for structure-based drug designing.
The molecular basis of transporter function will help to develop novel strategies to overcome the drug-resistance and enhance the clinical applications.
September 3, 2025 at 8:57 AM
The molecular basis of transporter function will help to develop novel strategies to overcome the drug-resistance and enhance the clinical applications.
In their recent paper (under revision), they report essential mechanistic details of substrate selection for PGs uptake transporter SLCO2A1(SLC21A2) through its cryo-EM structures bound to endogenous PGs and four widely prescribed medications for treating inflammation, chronic asthma & Parkinson’s.
September 3, 2025 at 8:57 AM
In their recent paper (under revision), they report essential mechanistic details of substrate selection for PGs uptake transporter SLCO2A1(SLC21A2) through its cryo-EM structures bound to endogenous PGs and four widely prescribed medications for treating inflammation, chronic asthma & Parkinson’s.
However, membrane transporter plays a critical role in regulating the biological actions of PGs in diverse tissues, including the lungs, liver, kidney, and female reproductive tissues.
September 3, 2025 at 8:57 AM
However, membrane transporter plays a critical role in regulating the biological actions of PGs in diverse tissues, including the lungs, liver, kidney, and female reproductive tissues.
Prostaglandins (PGs) are hormone-like lipid compounds involved in inflammation, pain and fever. The wide range of nonsteroidal anti-inflammatory drugs (NSAIDs) available to treat inflammation and pain, target prostaglandin synthase enzyme.
September 3, 2025 at 8:57 AM
Prostaglandins (PGs) are hormone-like lipid compounds involved in inflammation, pain and fever. The wide range of nonsteroidal anti-inflammatory drugs (NSAIDs) available to treat inflammation and pain, target prostaglandin synthase enzyme.
Chitra joined the group in 2022 as a postdoctoral researcher funded by Wellcome Trust. Her research projects focus on the structural characterization of human solute carriers (SLCs) particularly SLCO2A1 (SLC21A2; prostaglandin uptake) and SLC46A1 (PCFT; proton-coupled folate transporter).
September 3, 2025 at 8:57 AM
Chitra joined the group in 2022 as a postdoctoral researcher funded by Wellcome Trust. Her research projects focus on the structural characterization of human solute carriers (SLCs) particularly SLCO2A1 (SLC21A2; prostaglandin uptake) and SLC46A1 (PCFT; proton-coupled folate transporter).
#StemCellResearch
#Neuroscience
#Organoids
#CRISPR
#WomenInSTEM
#KavliOxford
@ndcnoxford.bsky.social
@medsci.ox.ac.uk
#Neuroscience
#Organoids
#CRISPR
#WomenInSTEM
#KavliOxford
@ndcnoxford.bsky.social
@medsci.ox.ac.uk
August 13, 2025 at 9:37 AM
Animal models do not fully replicate human cerebellar development. To address this, she is comparing protocols for generating cerebellar organoids and working on the development of CRISPR-based reporter lines to track specific cell populations throughout cerebellar maturation.
August 13, 2025 at 9:37 AM
Animal models do not fully replicate human cerebellar development. To address this, she is comparing protocols for generating cerebellar organoids and working on the development of CRISPR-based reporter lines to track specific cell populations throughout cerebellar maturation.
Due to its prolonged development—it is not fully mature at birth and continues developing until around two years of age—the cerebellum remains one of the most challenging brain regions to study.
August 13, 2025 at 9:37 AM
Due to its prolonged development—it is not fully mature at birth and continues developing until around two years of age—the cerebellum remains one of the most challenging brain regions to study.
The cerebellum is primarily associated with motor coordination, motor learning, balance and posture, but it has also been increasingly linked to cognitive and emotional processing.
August 13, 2025 at 9:37 AM
The cerebellum is primarily associated with motor coordination, motor learning, balance and posture, but it has also been increasingly linked to cognitive and emotional processing.
Her research focuses on the use of in vitro models—specifically cerebellar organoids derived from induced pluripotent stem cells—to study the development of the human cerebellum.
August 13, 2025 at 9:37 AM
Her research focuses on the use of in vitro models—specifically cerebellar organoids derived from induced pluripotent stem cells—to study the development of the human cerebellum.