Katrin Rittinger
@katrinrittinger.bsky.social
Structural biologist, ubiquitin enthusiast, Chemical Biology, amateur photographer. Views are my own.
Reposted by Katrin Rittinger
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:06 PM
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Reposted by Katrin Rittinger
Excited to Salmonella effector SteE featured on the cover of EMBO reports www.embopress.org/journal/1469...
July 27, 2025 at 8:19 AM
Excited to Salmonella effector SteE featured on the cover of EMBO reports www.embopress.org/journal/1469...
Reposted by Katrin Rittinger
📣Preprint 📣
You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/che...
You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/che...
Light-Activated Metal-dependent Protein Degradation (LAMP-D): A Heterobifunctional Ruthenium(II) Photosensitizer Targeting New Delhi Metallo-β-lactamase 1
The growth of antimicrobial resistance (AMR) is a significant global health threat, yet despite this alarming trend, antibiotic drug discovery has significantly slowed. Most compounds entering the cli...
doi.org
July 24, 2025 at 6:23 AM
📣Preprint 📣
You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/che...
You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/che...
Reposted by Katrin Rittinger
Second July issue is live.
-> www.embopress.org/toc/14693178...
featuring work by Teresa Thurston, Katrin Rittinger and co-workers @thurstonlab.bsky.social @katrinrittinger.bsky.social
@dunnschool.bsky.social @imperialcollegeldn.bsky.social
@crick.ac.uk.
More:
www.embopress.org/doi/full/10....
-> www.embopress.org/toc/14693178...
featuring work by Teresa Thurston, Katrin Rittinger and co-workers @thurstonlab.bsky.social @katrinrittinger.bsky.social
@dunnschool.bsky.social @imperialcollegeldn.bsky.social
@crick.ac.uk.
More:
www.embopress.org/doi/full/10....
July 23, 2025 at 9:07 AM
Second July issue is live.
-> www.embopress.org/toc/14693178...
featuring work by Teresa Thurston, Katrin Rittinger and co-workers @thurstonlab.bsky.social @katrinrittinger.bsky.social
@dunnschool.bsky.social @imperialcollegeldn.bsky.social
@crick.ac.uk.
More:
www.embopress.org/doi/full/10....
-> www.embopress.org/toc/14693178...
featuring work by Teresa Thurston, Katrin Rittinger and co-workers @thurstonlab.bsky.social @katrinrittinger.bsky.social
@dunnschool.bsky.social @imperialcollegeldn.bsky.social
@crick.ac.uk.
More:
www.embopress.org/doi/full/10....
Reposted by Katrin Rittinger
New from our lab @crick.ac.uk, in collaboration with the Enchev and Bukau labs.
By studying a protein that is difficult to fold, we discover fascinating new mechanisms by which the ribosome supports protein biogenesis.
www.biorxiv.org/content/10.1...
By studying a protein that is difficult to fold, we discover fascinating new mechanisms by which the ribosome supports protein biogenesis.
www.biorxiv.org/content/10.1...
June 2, 2025 at 4:12 PM
New from our lab @crick.ac.uk, in collaboration with the Enchev and Bukau labs.
By studying a protein that is difficult to fold, we discover fascinating new mechanisms by which the ribosome supports protein biogenesis.
www.biorxiv.org/content/10.1...
By studying a protein that is difficult to fold, we discover fascinating new mechanisms by which the ribosome supports protein biogenesis.
www.biorxiv.org/content/10.1...
Reposted by Katrin Rittinger
Very happy to share two back-to-back preprints of my postdoc work on bacterial NEL E3 ligases from my time in @katrinrittinger.bsky.social lab at @crick.ac.uk in collaboration with the ChemBio team at GSK (1/4)
May 21, 2025 at 2:26 PM
Very happy to share two back-to-back preprints of my postdoc work on bacterial NEL E3 ligases from my time in @katrinrittinger.bsky.social lab at @crick.ac.uk in collaboration with the ChemBio team at GSK (1/4)
Reposted by Katrin Rittinger
How can a Salmonella effector change the specificity of a host kinase? SteE mediates kinase reprogramming via mimicry of conserved eukaryotic-like motifs- doi.org/10.1038/s443... Great collaboration with @katrinrittinger.bsky.social + big thanks to all authors & congrats to lead PDRA Ioanna Panagi!
Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs | EMBO reports
imageimageA virulence protein from diverse bacteria switches the amino acid specificity of the
eukaryotic kinase GSK3. This kinase reprogramming depends on several short linear
motifs that each appear...
www.embopress.org
May 13, 2025 at 8:33 AM
How can a Salmonella effector change the specificity of a host kinase? SteE mediates kinase reprogramming via mimicry of conserved eukaryotic-like motifs- doi.org/10.1038/s443... Great collaboration with @katrinrittinger.bsky.social + big thanks to all authors & congrats to lead PDRA Ioanna Panagi!
Reposted by Katrin Rittinger
After a great review process with @naturecomms.bsky.social, I'm so happy to share our work identifying inactive RING E3 #ubiquitin #pseudoligases in the TRIM protein family!! rdcu.be/ehlGW
🥳 🍾 🙌
@katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk
🥳 🍾 🙌
@katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk
Identification of RING E3 pseudoligases in the TRIM protein family
Nature Communications - Understanding the catalytic and regulatory mechanisms of the ubiquitin system is key to tapping into its therapeutic potential in diseases where its dysfunction is...
rdcu.be
April 11, 2025 at 12:55 PM
After a great review process with @naturecomms.bsky.social, I'm so happy to share our work identifying inactive RING E3 #ubiquitin #pseudoligases in the TRIM protein family!! rdcu.be/ehlGW
🥳 🍾 🙌
@katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk
🥳 🍾 🙌
@katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk
Reposted by Katrin Rittinger
New preprint on how a minimal Salmonella kinase needs a host kinase to activate it. Work led by @timeshpillay.bsky.social and another great collaboration with @katrinrittinger.bsky.social @crick.ac.uk biorxiv.org/content/10.1...
Salmonella effector kinase SteC is activated by host-mediated phosphorylation
The pathogen Salmonella , which causes significant human morbidity and mortality, encodes an effector kinase, SteC, which mediates actin polymerisation and cell migration. Given the minimal nature of ...
biorxiv.org
March 7, 2025 at 9:20 PM
New preprint on how a minimal Salmonella kinase needs a host kinase to activate it. Work led by @timeshpillay.bsky.social and another great collaboration with @katrinrittinger.bsky.social @crick.ac.uk biorxiv.org/content/10.1...
Reposted by Katrin Rittinger
Looking forward to the monthly on-line seminars organized by the Protein Modules Community @pmc-modularity.bsky.social and talks on SLiMs, systems biology, signaling, computational biology and much more. First talks by Dr Gogl @teamgogl.bsky.social and Dr Dionne @gingraslab.bsky.social.
Join us for our new online seminar series, featuring two talks on protein modules every month! The first session kicks off at 6pm CET Feb 10 with Dr. Gergő Gógl and Dr. Ugo Dionne.
Register to attend: tinyurl.com/register-pmc-seminar
Register to attend: tinyurl.com/register-pmc-seminar
January 15, 2025 at 5:59 PM
Looking forward to the monthly on-line seminars organized by the Protein Modules Community @pmc-modularity.bsky.social and talks on SLiMs, systems biology, signaling, computational biology and much more. First talks by Dr Gogl @teamgogl.bsky.social and Dr Dionne @gingraslab.bsky.social.
Reposted by Katrin Rittinger
Happy to share our new paper, out now in @commschem.bsky.social. Was great working with Aini and @katmcphie.bsky.social on this! We used chemoproteomics and HTC to find an enantioselective hit for OTUD7B.
www.nature.com/articles/s42...
@katrinrittinger.bsky.social @jtbush.bsky.social @crick.ac.uk
www.nature.com/articles/s42...
@katrinrittinger.bsky.social @jtbush.bsky.social @crick.ac.uk
Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation - Communications Chemistry
The ovarian tumour protease (OTU) family of deubiquitinating enzymes (DUBs) are biochemically well-characterised and of therapeutic interest, however, only a few tool compounds exist to study their ce...
www.nature.com
January 15, 2025 at 10:01 AM
Happy to share our new paper, out now in @commschem.bsky.social. Was great working with Aini and @katmcphie.bsky.social on this! We used chemoproteomics and HTC to find an enantioselective hit for OTUD7B.
www.nature.com/articles/s42...
@katrinrittinger.bsky.social @jtbush.bsky.social @crick.ac.uk
www.nature.com/articles/s42...
@katrinrittinger.bsky.social @jtbush.bsky.social @crick.ac.uk
Reposted by Katrin Rittinger
Excited to share a key part of my postdoctoral work from @crick.ac.uk and GSK, published in Nature Communications. A collaborative project to develop a high-throughput chemoproteomics platform for profiling cysteine-reactive fragments in native biological systems.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics - Nature Communications
This paper presents a label-free chemoproteomics platform using data-independent acquisition to profile covalent fragment binding across the human proteome. The platform offers high reproducibility an...
www.nature.com
January 10, 2025 at 12:20 PM
Excited to share a key part of my postdoctoral work from @crick.ac.uk and GSK, published in Nature Communications. A collaborative project to develop a high-throughput chemoproteomics platform for profiling cysteine-reactive fragments in native biological systems.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Katrin Rittinger
If you are interested in 𝗔𝗰𝘁𝗶𝘃𝗶𝘁𝘆-𝗕𝗮𝘀𝗲𝗱 𝗣𝗿𝗼𝘁𝗲𝗶𝗻 𝗣𝗿𝗼𝗳𝗶𝗹𝗶𝗻𝗴, definitely consider the #ABPP2025 conference on March 30th to April 2nd, 2025, at The Francis Crick Institute.
Registration deadlines have been updated.
www.linkedin.com/posts/14th-i...
Registration deadlines have been updated.
www.linkedin.com/posts/14th-i...
14th International Activity Based Protein Profiling (ABPP) Meeting on LinkedIn: REGISTRATIONS DEADLINES UPDATE!
Early Bird registration (🐣) has been…
REGISTRATIONS DEADLINES UPDATE!
Early Bird registration (🐣) has been extended to the 30th of January and Late Registrations (🦉) end on the 28th of February…
www.linkedin.com
January 9, 2025 at 10:20 AM
If you are interested in 𝗔𝗰𝘁𝗶𝘃𝗶𝘁𝘆-𝗕𝗮𝘀𝗲𝗱 𝗣𝗿𝗼𝘁𝗲𝗶𝗻 𝗣𝗿𝗼𝗳𝗶𝗹𝗶𝗻𝗴, definitely consider the #ABPP2025 conference on March 30th to April 2nd, 2025, at The Francis Crick Institute.
Registration deadlines have been updated.
www.linkedin.com/posts/14th-i...
Registration deadlines have been updated.
www.linkedin.com/posts/14th-i...