Karl Gademann
@karlgademann.bsky.social
Organiker. Synthetiker.
And congratulations to the whole team involved! /fin
December 19, 2024 at 2:46 PM
And congratulations to the whole team involved! /fin
Read more in our study published at www.nature.com/articles/s42...
Functional biosynthetic stereodivergence in a gene cluster via a dihydrosydnone N-oxide - Communications Chemistry
The ham gene cluster in Burkholderia cenocepacia H111 produces two compounds: the signalling molecule valdiazen as racemate and the antifungal fragin in enantiopure form. Here, the authors demonstrate...
www.nature.com
December 19, 2024 at 2:46 PM
Read more in our study published at www.nature.com/articles/s42...
I always wanted to work with sydnones, and now these are competent biosynthetic intermediates! And we have an X-ray crystal structure
December 19, 2024 at 2:46 PM
I always wanted to work with sydnones, and now these are competent biosynthetic intermediates! And we have an X-ray crystal structure
Now comes the unusual finding ... an unusual heterocycle is involved in both biosyntheses in a stereodivergent fashion
December 19, 2024 at 2:46 PM
Now comes the unusual finding ... an unusual heterocycle is involved in both biosyntheses in a stereodivergent fashion
On top of this, highly unusual that both a racemic compound and an enantiomerically pure compound are derived from the same biosynthetic gene cluster.
December 19, 2024 at 2:46 PM
On top of this, highly unusual that both a racemic compound and an enantiomerically pure compound are derived from the same biosynthetic gene cluster.
The biosynthesis of diazeniumdiolates (yes this strange functional group) remains enigmatic
December 19, 2024 at 2:46 PM
The biosynthesis of diazeniumdiolates (yes this strange functional group) remains enigmatic