Final presentation at the Bürgenstock conference: Todd Hyster from Princeton #bc_scs25

Start of the 2025 Irsee conference by @HartungIngo , Looking forward to three exciting days of natural product chemistry!

I always wanted to work with sydnones, and now these are competent biosynthetic intermediates! And we have an X-ray crystal structure

Now comes the unusual finding ... an unusual heterocycle is involved in both biosyntheses in a stereodivergent fashion

On top of this, highly unusual that both a racemic compound and an enantiomerically pure compound are derived from the same biosynthetic gene cluster.

The biosynthesis of diazeniumdiolates (yes this strange functional group) remains enigmatic

Unusual heterocycles and biosynthesis of natural products, published today in Communications Chemistry 🧵

The great chemistry bake off at UZH, congrats to Ana and Erik for the most artistic cake!