Kaitlyn Kiernan
@kaitlynakiernan.bsky.social
Postdoc in the Sazanov lab at ISTAustria. Using structural biology to find meaning in a world ruled by microbes. 🔬🦠
After DNA cleavage, the PAM-distal product dissociates but the PAM-proximal DNA remains bound. Cas9 reverts almost entirely back to the binary complex but is blocked from binding new targets until the PAM-proximal product is released. Check out the paper for more details!
July 2, 2025 at 11:30 AM
After DNA cleavage, the PAM-distal product dissociates but the PAM-proximal DNA remains bound. Cas9 reverts almost entirely back to the binary complex but is blocked from binding new targets until the PAM-proximal product is released. Check out the paper for more details!