Jungsu Kim
@jungsukim77.bsky.social
Alzheimer, APOE, Actin, Txn factors, Immune, Tau, miRs, Drugs | Single cell & Spatial omics, Proteomics, QTL | ASO, RNAi, AAV | Mouse, iPSC, Drosophila, Zebrafish | Microglia, Astrocytes, Oligodendrocytes https://medicine.iu.edu/faculty/41977/kim-jungsu
Pinned
Jungsu Kim
@jungsukim77.bsky.social
· Feb 1
This article in Nature didn't make any sense to me.
I disliked the fanfare about this article so much that I dedicated a subchapter in my Ph.D. thesis in 2006 & I left the Amyloid and moved to APOE research.
"Chapter 7.2 What is Abeta star*?"
I disliked the fanfare about this article so much that I dedicated a subchapter in my Ph.D. thesis in 2006 & I left the Amyloid and moved to APOE research.
"Chapter 7.2 What is Abeta star*?"
Reposted by Jungsu Kim
Frost lab paper alert! This study was led by Dr. Paul Ramirez, Lead Biostatistician for the Brown University Center for Alzheimer’s Disease Research: alz-journals.onlinelibrary.wiley.com/doi/epdf/10.... 1/9
Long‐read sequencing reveals genomic and epigenomic variation in the dark genome of human Alzheimer's disease
You have to enable JavaScript in your browser's settings in order to use the eReader.
alz-journals.onlinelibrary.wiley.com
November 14, 2025 at 5:07 PM
Frost lab paper alert! This study was led by Dr. Paul Ramirez, Lead Biostatistician for the Brown University Center for Alzheimer’s Disease Research: alz-journals.onlinelibrary.wiley.com/doi/epdf/10.... 1/9
Reposted by Jungsu Kim
Our new review is out today!
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks
Metabolic inflexibility in Alzheimer's disease. Schematic illustrating the biphasic trajectory of metabolic activity relative to canonical Alzheimer's disease (AD) biomarkers. In the presymptomatic p...
onlinelibrary.wiley.com
November 13, 2025 at 8:17 PM
Our new review is out today!
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
"Years after Brigham-Harvard scandal, U.S. pours millions into tainted stem-cell field"
www.reuters.com/investigates...
A bit outdated news
Fabricated data in most research fields
Reminds me of the following article
"Why Most Published Research Findings Are False"
journals.plos.org/plosmedicine...
www.reuters.com/investigates...
A bit outdated news
Fabricated data in most research fields
Reminds me of the following article
"Why Most Published Research Findings Are False"
journals.plos.org/plosmedicine...
www.reuters.com
November 12, 2025 at 10:33 PM
"Years after Brigham-Harvard scandal, U.S. pours millions into tainted stem-cell field"
www.reuters.com/investigates...
A bit outdated news
Fabricated data in most research fields
Reminds me of the following article
"Why Most Published Research Findings Are False"
journals.plos.org/plosmedicine...
www.reuters.com/investigates...
A bit outdated news
Fabricated data in most research fields
Reminds me of the following article
"Why Most Published Research Findings Are False"
journals.plos.org/plosmedicine...
Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes - Al‐Amin - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes
INTRODUCTION
The ε4 allele of the apolipoprotein E (APOE) gene is a risk factor for the development of Alzheimer's disease (AD). APOE4 isoform is associated with increased white matter lesions in hu.....
alz-journals.onlinelibrary.wiley.com
November 11, 2025 at 4:37 AM
Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes - Al‐Amin - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
A very expensive R21 grant paid off well 🤩
November 2, 2025 at 2:18 AM
A very expensive R21 grant paid off well 🤩
Reposted by Jungsu Kim
Reposted by Jungsu Kim
Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com
October 21, 2025 at 1:06 AM
Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
An interesting behind story.
From a random mutant MOUSE 🐁 model To a HUMAN disease!
Of course, Mouse models can be useful for understanding peripheral immune in Humans too.
www.nobelprize.org/prizes/medic...
From a random mutant MOUSE 🐁 model To a HUMAN disease!
Of course, Mouse models can be useful for understanding peripheral immune in Humans too.
www.nobelprize.org/prizes/medic...
October 6, 2025 at 1:05 PM
An interesting behind story.
From a random mutant MOUSE 🐁 model To a HUMAN disease!
Of course, Mouse models can be useful for understanding peripheral immune in Humans too.
www.nobelprize.org/prizes/medic...
From a random mutant MOUSE 🐁 model To a HUMAN disease!
Of course, Mouse models can be useful for understanding peripheral immune in Humans too.
www.nobelprize.org/prizes/medic...
The future of universities: A Nature special report share.google/CkHwmHHBIU1K...
The future of universities: A Nature special report
The world's universities are under intense pressure. Nature examines the threats they face and asks how the sector can and must adapt to survive.
share.google
September 28, 2025 at 1:51 PM
The future of universities: A Nature special report share.google/CkHwmHHBIU1K...
"But given the growing emphasis on funding in many quarters as the sine qua non of academic achievement, we may reach the point where faculty members' obituaries will read along the lines of, "Professor X didn't leave much of an intellectual legacy, but he/she sure brought in a lot of grant money""
September 20, 2025 at 4:01 PM
"But given the growing emphasis on funding in many quarters as the sine qua non of academic achievement, we may reach the point where faculty members' obituaries will read along the lines of, "Professor X didn't leave much of an intellectual legacy, but he/she sure brought in a lot of grant money""
"FlyBase’s now-uncertain future highlights just how interconnected and interdependent research efforts are and how the effects of funding cuts to one institution can ripple worldwide. More than 4,000 labs use FlyBase."
share.google/vYzdfRwVpnHb...
share.google/vYzdfRwVpnHb...
Trump's Harvard cuts threaten a giant in biomedical research: A database about the tiny fruit fly
This spring, the Trump administration rescinded a grant that maintained FlyBase, a pillar of global basic research, as part of its broader $2.2 billion funding cuts at Harvard.
share.google
September 16, 2025 at 12:14 AM
"FlyBase’s now-uncertain future highlights just how interconnected and interdependent research efforts are and how the effects of funding cuts to one institution can ripple worldwide. More than 4,000 labs use FlyBase."
share.google/vYzdfRwVpnHb...
share.google/vYzdfRwVpnHb...
Nevertheless, these two brief papers in BBRC, although not viewed as potentially seminal in the months after their publication, turned out to provide both the factual and conceptual underpinnings for all subsequent research on β-amyloidosis in AD
By Masters & Selkoe
pubmed.ncbi.nlm.nih.gov/22675658/
By Masters & Selkoe
pubmed.ncbi.nlm.nih.gov/22675658/
September 14, 2025 at 7:19 PM
Nevertheless, these two brief papers in BBRC, although not viewed as potentially seminal in the months after their publication, turned out to provide both the factual and conceptual underpinnings for all subsequent research on β-amyloidosis in AD
By Masters & Selkoe
pubmed.ncbi.nlm.nih.gov/22675658/
By Masters & Selkoe
pubmed.ncbi.nlm.nih.gov/22675658/
🤩Additional funding for AD & ADRD
Fiscal Year 2027 NIH Professional Judgment Budget for Alzheimer’s Disease and Related Dementias Research: Advancing Progress in Dementia Research
www.nia.nih.gov/about/budget...
Fiscal Year 2027 NIH Professional Judgment Budget for Alzheimer’s Disease and Related Dementias Research: Advancing Progress in Dementia Research
www.nia.nih.gov/about/budget...
Fiscal Year 2027 NIH Professional Judgment Budget for Alzheimer’s Disease and Related Dementias Research: Advancing Progress in Dementia Research
The budget proposal outlines the additional funding needed in FY27 to advance NIH-supported research toward achieving the goals outlined by the National Plan to Address Alzheimer’s Disease.
www.nia.nih.gov
September 8, 2025 at 10:15 PM
🤩Additional funding for AD & ADRD
Fiscal Year 2027 NIH Professional Judgment Budget for Alzheimer’s Disease and Related Dementias Research: Advancing Progress in Dementia Research
www.nia.nih.gov/about/budget...
Fiscal Year 2027 NIH Professional Judgment Budget for Alzheimer’s Disease and Related Dementias Research: Advancing Progress in Dementia Research
www.nia.nih.gov/about/budget...
Reproducibility and Best Practices in Cell Biology
rupress.org/jcb/collecti...
rupress.org/jcb/collecti...
Reproducibility and Best Practices in Cell Biology | Journal of Cell Biology | Rockefeller University Press
rupress.org
September 3, 2025 at 5:49 PM
Reproducibility and Best Practices in Cell Biology
rupress.org/jcb/collecti...
rupress.org/jcb/collecti...
🤯 Postmortem vs Living brain
Due to the unavailability of brain tissue from living people, most such studies are performed using tissue from postmortem brain.
"Expression levels differed significantly for nearly 80% of genes,"🤯
www.nature.com/articles/s41...
Due to the unavailability of brain tissue from living people, most such studies are performed using tissue from postmortem brain.
"Expression levels differed significantly for nearly 80% of genes,"🤯
www.nature.com/articles/s41...
A study of gene expression in the living human brain - Molecular Psychiatry
Molecular Psychiatry - A study of gene expression in the living human brain
www.nature.com
August 28, 2025 at 1:21 PM
🤯 Postmortem vs Living brain
Due to the unavailability of brain tissue from living people, most such studies are performed using tissue from postmortem brain.
"Expression levels differed significantly for nearly 80% of genes,"🤯
www.nature.com/articles/s41...
Due to the unavailability of brain tissue from living people, most such studies are performed using tissue from postmortem brain.
"Expression levels differed significantly for nearly 80% of genes,"🤯
www.nature.com/articles/s41...
"it’s hard for me to believe that damaging the greatest biomedical research system in the world is the way to solve any problems, let alone the problem of antisemitism."
A little hesitant to post this on here, as I wrote it specifically for the Jewish community in Detroit...but maybe it'll inspire other scientists to write articles in their hometown papers. www.thejewishnews.com/opinion/biom...
Biomedical Research Deserves Support
I know that our country is very divided right now, but I still have some hope that most Americans can at least come together around the idea of supporting biomedical research.
www.thejewishnews.com
August 22, 2025 at 6:58 PM
"it’s hard for me to believe that damaging the greatest biomedical research system in the world is the way to solve any problems, let alone the problem of antisemitism."
End the unchecked growth of publishing fees and the overreliance on unpaid peer review
A proposed NIH policy to limit allowable publication costs is a good start — but more must be done
Peer reviewers should be paid for their considerable labor | STAT share.google/YXf4iuUCa9Zp...
A proposed NIH policy to limit allowable publication costs is a good start — but more must be done
Peer reviewers should be paid for their considerable labor | STAT share.google/YXf4iuUCa9Zp...
End the unchecked growth of publishing fees and the overreliance on unpaid peer review
High publishing costs and a crumbling peer review infrastructure are symptoms of deeper structural issues in research.
share.google
August 20, 2025 at 1:05 AM
End the unchecked growth of publishing fees and the overreliance on unpaid peer review
A proposed NIH policy to limit allowable publication costs is a good start — but more must be done
Peer reviewers should be paid for their considerable labor | STAT share.google/YXf4iuUCa9Zp...
A proposed NIH policy to limit allowable publication costs is a good start — but more must be done
Peer reviewers should be paid for their considerable labor | STAT share.google/YXf4iuUCa9Zp...
NIH chief calls for immediate research review, dangling threat of project termination
By Darren Incorvaia
Aug 15, 2025 3:53pm
www.fiercebiotech.com/research/nih...
By Darren Incorvaia
Aug 15, 2025 3:53pm
www.fiercebiotech.com/research/nih...
NIH chief calls for immediate research review, dangling threat of project termination
Jayanta Bhattacharya, M.D., Ph.D., director of the National Institutes of Health (NIH), has called on the agency’s scientific leadership to immediately review all of their current and planned resea | ...
www.fiercebiotech.com
August 16, 2025 at 1:05 PM
NIH chief calls for immediate research review, dangling threat of project termination
By Darren Incorvaia
Aug 15, 2025 3:53pm
www.fiercebiotech.com/research/nih...
By Darren Incorvaia
Aug 15, 2025 3:53pm
www.fiercebiotech.com/research/nih...
"hyperphosphorylated tau PREVENTS the age-related decline in whole-body metabolism by preserving glucose tolerance and mitigating shifts in fuel utilization (respiratory exchange ratio; RER),"
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance https://www.biorxiv.org/content/10.1101/2025.07.25.666872v1
July 31, 2025 at 5:25 PM
"hyperphosphorylated tau PREVENTS the age-related decline in whole-body metabolism by preserving glucose tolerance and mitigating shifts in fuel utilization (respiratory exchange ratio; RER),"
Reposted by Jungsu Kim
😡 The amount of bureaucratic barriers being thrown up for me to host an URM student from an urban high school and pay her a small stipend so she can afford to take this opportunity is making me absolutely stabby. Barriers to participation in STEM are real and undiminished.
July 22, 2025 at 3:35 PM
😡 The amount of bureaucratic barriers being thrown up for me to host an URM student from an urban high school and pay her a small stipend so she can afford to take this opportunity is making me absolutely stabby. Barriers to participation in STEM are real and undiminished.
Top-down and bottom-up neuroscience: overcoming the clash of research cultures | Nature Reviews Neuroscience share.google/WVex5VystbkH...
Top-down and bottom-up neuroscience: overcoming the clash of research cultures - Nature Reviews Neuroscience
As scientists, we want solid answers, but we also want to answer questions that matter. Yet, the brain’s complexity forces trade-offs between these desiderata, bringing about two distinct research app...
share.google
July 22, 2025 at 5:16 PM
Top-down and bottom-up neuroscience: overcoming the clash of research cultures | Nature Reviews Neuroscience share.google/WVex5VystbkH...
Highly recommend everyone take a look!
I especially like "Transcriptomic reprogramming represents a promising strategy for treating complex diseases"😍
Title: Cell-type-directed network-correcting combination therapy for Alzheimer’s disease
www.cell.com/cell/fulltex...
I especially like "Transcriptomic reprogramming represents a promising strategy for treating complex diseases"😍
Title: Cell-type-directed network-correcting combination therapy for Alzheimer’s disease
www.cell.com/cell/fulltex...
Cell-type-directed network-correcting combination therapy for Alzheimer’s disease
A multi-cell-type drug discovery strategy targeting dysregulated gene networks in
neurons and glia identified letrozole and irinotecan as a combination therapy that
significantly improved memory and r...
www.cell.com
July 21, 2025 at 11:28 PM
Highly recommend everyone take a look!
I especially like "Transcriptomic reprogramming represents a promising strategy for treating complex diseases"😍
Title: Cell-type-directed network-correcting combination therapy for Alzheimer’s disease
www.cell.com/cell/fulltex...
I especially like "Transcriptomic reprogramming represents a promising strategy for treating complex diseases"😍
Title: Cell-type-directed network-correcting combination therapy for Alzheimer’s disease
www.cell.com/cell/fulltex...
More than a decade-old story, but it resonates again now.
"NIA is in an exceptional predicament. In recent years, it has made big commitments to costly clinical trials and large group projects."
www.nature.com/articles/468...
The value of top-down big projects needs to be reevaluated, especially now
"NIA is in an exceptional predicament. In recent years, it has made big commitments to costly clinical trials and large group projects."
www.nature.com/articles/468...
The value of top-down big projects needs to be reevaluated, especially now
Funding crisis hits US ageing research - Nature
Shortfalls hamper scientists' efforts to address a predicted epidemic of age-related diseases.
www.nature.com
July 20, 2025 at 10:47 PM
More than a decade-old story, but it resonates again now.
"NIA is in an exceptional predicament. In recent years, it has made big commitments to costly clinical trials and large group projects."
www.nature.com/articles/468...
The value of top-down big projects needs to be reevaluated, especially now
"NIA is in an exceptional predicament. In recent years, it has made big commitments to costly clinical trials and large group projects."
www.nature.com/articles/468...
The value of top-down big projects needs to be reevaluated, especially now
Better Together: ORCID and Other Researcher Identifiers
scholarlykitchen.sspnet.org/2025/07/16/b...
scholarlykitchen.sspnet.org/2025/07/16/b...
Better Together: ORCID and Other Researcher Identifiers - The Scholarly Kitchen
This post is based on a recently-published white paper by Alice Meadows and Josh Brown of MoreBrains Cooperative, in which they discuss why ORCID iDs work best in combination with other researcher ide...
scholarlykitchen.sspnet.org
July 20, 2025 at 9:25 PM
Better Together: ORCID and Other Researcher Identifiers
scholarlykitchen.sspnet.org/2025/07/16/b...
scholarlykitchen.sspnet.org/2025/07/16/b...
"It also calls on Duke’s highest paid administrators and athletic personnel — those making over $500,000 — to consider voluntary, temporary pay cuts to offset the costs of a reduced budget, as opposed to laying off staff."
www.dukechronicle.com/article/2025...
www.dukechronicle.com/article/2025...
American Association of University Professors calls on Duke to 'immediately halt' its employee buyout program
The statement, signed by AAUP president Todd Wolfson, alleges that Duke did not consult faculty and staff in decision-making prior to rolling out the VSIP and has not been transparent with its cost-cu...
www.dukechronicle.com
July 19, 2025 at 6:35 PM
"It also calls on Duke’s highest paid administrators and athletic personnel — those making over $500,000 — to consider voluntary, temporary pay cuts to offset the costs of a reduced budget, as opposed to laying off staff."
www.dukechronicle.com/article/2025...
www.dukechronicle.com/article/2025...