Julie Trolle
@julietrolle.bsky.social
Engineering mammalian cells | Boeke Lab, NYU
Reposted by Julie Trolle
Excited to share our work with @julietrolle.bsky.social & Jef Boeke.
We developed a 'shotgun' method to screen millions of synthetic metabolic pathways to enable mammalian cells to grow without two essential nutrients for the first time in >500 million years!
doi.org/10.1101/2025...
Thread...
We developed a 'shotgun' method to screen millions of synthetic metabolic pathways to enable mammalian cells to grow without two essential nutrients for the first time in >500 million years!
doi.org/10.1101/2025...
Thread...
A shotgun approach for highly multiplexed mammalian metabolic engineering
Mammalian metabolic engineering is critical to advancing basic biology, bioproduction, and cell therapy. However, as pathway complexity increases, so does the size of both the combinatorial design spa...
doi.org
July 14, 2025 at 10:36 PM
Excited to share our work with @julietrolle.bsky.social & Jef Boeke.
We developed a 'shotgun' method to screen millions of synthetic metabolic pathways to enable mammalian cells to grow without two essential nutrients for the first time in >500 million years!
doi.org/10.1101/2025...
Thread...
We developed a 'shotgun' method to screen millions of synthetic metabolic pathways to enable mammalian cells to grow without two essential nutrients for the first time in >500 million years!
doi.org/10.1101/2025...
Thread...