Júlia Bonjoch
@juliabonjoch.bsky.social
PhD student at the Stem Cells and Cancer Lab (Aznar Benitah lab) at IRB Barcelona.
Interested in aging, skin, epigenetics and more!🧬🐁
Interested in aging, skin, epigenetics and more!🧬🐁
Reposted by Júlia Bonjoch
Thrilled to share our story in its final form! nature.com/articles/s41... 💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.
https://nature.com/articles/s41467-025-63778-4💥
September 10, 2025 at 2:26 PM
Thrilled to share our story in its final form! nature.com/articles/s41... 💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.
Reposted by Júlia Bonjoch
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...
Computational image analyst (m/f/d)
The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a
jobs.mpi-muenster.mpg.de
September 12, 2025 at 6:17 AM
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...
Reposted by Júlia Bonjoch
SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging
SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging
Tran et al. determined that the protein deacetylase SIRT7 is degraded during senescence by the E3 ligase TRIP12. SIRT7 binds to NUCKS1 and, upon SIRT7 loss, NUCKS1 is acetylated and recruited onto chromatin, where it regulates genes involved in senescence and aging. This SIRT7-NUCKS1 relationship was also demonstrated during liver aging.
dlvr.it
June 20, 2025 at 10:57 PM
SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging
Hi Bluesky community:)
Our new manuscript is now available as a preprint!⛅️
biorxiv.org/content/10.1...
1/ Here, we describe a novel BMAL1-YAP complex in epidermal cells, which is hijacked during ageing to control the expression of up-regulated inflammation genes through enhancer binding.🧵
Our new manuscript is now available as a preprint!⛅️
biorxiv.org/content/10.1...
1/ Here, we describe a novel BMAL1-YAP complex in epidermal cells, which is hijacked during ageing to control the expression of up-regulated inflammation genes through enhancer binding.🧵
BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis
Ageing is characterised by persistent low-grade inflammation that is linked to impaired tissue homeostasis and functionality. However, the molecular mechanisms driving age-associated inflammation rema...
biorxiv.org
April 23, 2025 at 2:49 PM
Hi Bluesky community:)
Our new manuscript is now available as a preprint!⛅️
biorxiv.org/content/10.1...
1/ Here, we describe a novel BMAL1-YAP complex in epidermal cells, which is hijacked during ageing to control the expression of up-regulated inflammation genes through enhancer binding.🧵
Our new manuscript is now available as a preprint!⛅️
biorxiv.org/content/10.1...
1/ Here, we describe a novel BMAL1-YAP complex in epidermal cells, which is hijacked during ageing to control the expression of up-regulated inflammation genes through enhancer binding.🧵
Reposted by Júlia Bonjoch
🌟 Excited to share that our latest preprint is now available! We’re one step closer to understanding the complex mechanisms behind ageing and inflammation.
👉 Read the preprint here: www.biorxiv.org/cgi/content/...
Thank you to everyone who supported and believed in this project along the way!
👉 Read the preprint here: www.biorxiv.org/cgi/content/...
Thank you to everyone who supported and believed in this project along the way!
BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis
Ageing is characterised by persistent low-grade inflammation that is linked to impaired tissue homeostasis and functionality. However, the molecular mechanisms driving age-associated inflammation rema...
www.biorxiv.org
April 23, 2025 at 12:47 PM
🌟 Excited to share that our latest preprint is now available! We’re one step closer to understanding the complex mechanisms behind ageing and inflammation.
👉 Read the preprint here: www.biorxiv.org/cgi/content/...
Thank you to everyone who supported and believed in this project along the way!
👉 Read the preprint here: www.biorxiv.org/cgi/content/...
Thank you to everyone who supported and believed in this project along the way!
Reposted by Júlia Bonjoch
🧪 ✍️ Please check out our new review on intercellular and interorgan communication between circadian clocks ⏰🧬 out today in Nature Reviews Molecular Cell Biology 🎉
@natrevmcb.bsky.social
! Here is the SharedIt link for free access: rdcu.be/d5ppE
@natrevmcb.bsky.social
! Here is the SharedIt link for free access: rdcu.be/d5ppE
Circadian clock communication during homeostasis and ageing
Nature Reviews Molecular Cell Biology - Communication between the circadian clocks of different cell and tissue types supports the daily rhythms of homeostatic processes that maintain bodily...
rdcu.be
January 3, 2025 at 12:00 PM
🧪 ✍️ Please check out our new review on intercellular and interorgan communication between circadian clocks ⏰🧬 out today in Nature Reviews Molecular Cell Biology 🎉
@natrevmcb.bsky.social
! Here is the SharedIt link for free access: rdcu.be/d5ppE
@natrevmcb.bsky.social
! Here is the SharedIt link for free access: rdcu.be/d5ppE